# Good Molecules Niacinamide Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Good Molecules](https://lovi.care/skincare/sg/brands/good-molecules)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Suitable for normal skin, this serum utilizes niacinamide and glycerin to provide antioxidant and humectant benefits, which support hydration and offer mild improvements for wrinkles and fine lines.
- The formula also includes betaine and dipropylene glycol to further enhance skin hydration and texture, contributing to overall skin health.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glycerin, Dipropylene Glycol, Betaine, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation. ([Food and Chemical Toxicology, 1998](https://pubmed.ncbi.nlm.nih.gov/9609395/))
- Polyhexanide/betaine may be nontoxic and effective in enhancing wound healing, whereas the majority of other topical cleaning agents are locally toxic and of limited or no proven efficacy. ([Advances in Skin & Wound Care, 2013](https://pubmed.ncbi.nlm.nih.gov/23507692/))

## What reviewers say

Based on a very large amount of data, this serum is highly regarded for its lightweight, non-sticky feel and its effectiveness in visibly reducing pores and smoothing skin texture, all at an accessible price. Many users found it beneficial for controlling oil and redness. A smaller number of users reported experiencing breakouts or irritation, indicating it might not be suitable for all sensitive skin types.

- Liked: Affordable price (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Minimizes pores (often mentioned)
- Liked: Controls oil/redness (sometimes noted)
- Liked: Elegant texture (sometimes noted)
- Disliked: Caused breakouts (sometimes noted)
- Disliked: No visible results (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the Good Molecules Niacinamide Serum work for mature skin?

This serum works for mature skin by using niacinamide and glycerin to support hydration and help smooth out fine lines, though other products fit this skin type better. It is important for a product of this type to be exceptionally safe with no risk of irritation, effectively target wrinkles and fine lines with high-quality ingredients, perform its intended anti-aging function excellently, and be perfectly suitable for normal skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Niacinamide and glycerin make this serum a good fit for mature skin by supporting hydration and offering mild improvements for wrinkles and fine lines, while betaine and dipropylene glycol enhance overall texture. To provide a better fit for mature skin, a product of this type needs high concentrations of potent antioxidants, skin-repairing ingredients, and peptides that effectively target wrinkles, improve elasticity, and ensure optimal moisture retention.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after your cleanser and toner, and before your moisturizer. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to keep your skin calm and hydrated before layering retinol on top. This product is unlikely to cause irritation because it lacks harsh ingredients and includes soothing components. To better support mature skin, a product of this type needs richer anti-aging ingredients and deep moisturizers.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is very gentle and unlikely to cause irritation, so mature skin benefits when it is paired with richer moisturizers, antioxidants, and retinols to better smooth fine lines and boost hydration.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum may occasionally cause breakouts, as some reviewers have reported. To better suit mature skin and minimize breakout risks, a product of this type needs soothing ingredients and hydration boosters like niacinamide and glycerin.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

- Amazon.sg: S$56.22 (https://www.amazon.sg/dp/B0BX32CXP6?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Niacinamide, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Betaine, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Ethylhexylglycerin, Polysorbate 60, Sorbitan Isostearate, Diphenyl Dimethicone, Disodium Edta, Triethylhexanoin, Polyglyceryl-10 Oleate, Hydrogenated Lecithin, Phenoxyethanol, Chlorphenesin, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/good-molecules/niacinamide-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/good-molecules/niacinamide-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/good-molecules/niacinamide-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/good-molecules/niacinamide-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/good-molecules/niacinamide-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/good-molecules/niacinamide-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/good-molecules/niacinamide-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/good-molecules/niacinamide-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/good-molecules/niacinamide-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/good-molecules/niacinamide-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/good-molecules/niacinamide-serum/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/good-molecules/niacinamide-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/good-molecules/niacinamide-serum/for/mature-skin