# Eighth Day Regenerative Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Eighth Day](https://lovi.care/skincare/sg/brands/eighth-day)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent for your normal skin, this serum's multiple peptides like Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 promote collagen synthesis to effectively address wrinkles and fine lines.
- The inclusion of Sodium Hyaluronate and Niacinamide further supports barrier repair and hydration, enhancing the overall regenerative benefits for your skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Allantoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide-Rich Plasma, Sodium Hyaluronate, Niacinamide, Acetyl Glutamine, Manuka Honey

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients. ([Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40167803/))
- Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars. ([Journal of Cutaneous and Aesthetic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/38800810/))
- Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346518/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes. ([The Ocular Surface, 2020](https://pubmed.ncbi.nlm.nih.gov/31759183/))
- Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks. ([The British Journal of Ophthalmology, 2022](https://pubmed.ncbi.nlm.nih.gov/33419788/))
- The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing. ([Medical Science Monitor, 2010](https://pubmed.ncbi.nlm.nih.gov/20980964/))

## What reviewers say

This serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.

- Disliked: High price (mostly mentioned)
- Liked: Fast absorption (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Liked: High-tech ingredients (sometimes noted)
- Liked: Hydration (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Liked: Packaging (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: No acne benefit (rarely noted)
- Disliked: Texture complaints (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Eighth Day Regenerative Serum a great fit for mature skin?

This serum is a great fit for mature skin because its multiple peptides help smooth fine lines and wrinkles by promoting collagen, while sodium hyaluronate and niacinamide boost hydration and support the skin barrier. It is very gentle on your skin with zero harsh ingredients and includes soothing components like allantoin.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains multiple peptides like Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-5 that help smooth out fine lines and wrinkles. It also includes sodium hyaluronate, niacinamide, and manuka honey to boost hydration and keep your skin looking firm and soft.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Peptide-Rich Plasma do for mature skin?

Peptide-rich plasma helps mature skin by enhancing tissue repair, increasing collagen production, and reducing wrinkles, texture, and pores. These treatments may improve skin hydration and brightness while supporting overall skin rejuvenation.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41226837/), [Experimental and Therapeutic Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32256789/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe around sun exposure. It is unlikely to irritate mature skin because it leaves out harsh ingredients and includes soothing components like Allantoin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to let its multiple peptides and sodium hyaluronate absorb deeply before following with retinol. This routine helps smooth fine lines and maintain moisture while keeping your skin calm and comfortable.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### How often should I use this serum?

This serum fits well into your evening routine as a treatment step, and it is safe to use daily. Multiple peptides and hydrating ingredients help smooth fine lines and support your skin barrier without irritation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. Its formula avoids heavy, pore-clogging ingredients and includes soothing components like allantoin to maintain a safe and comfortable profile for your skin.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/eighth-day/regenerative-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/eighth-day/regenerative-serum/for/mature-skin
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- Italy: https://lovi.care/skincare/it/p/eighth-day/regenerative-serum/for/mature-skin
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- Canada: https://lovi.care/skincare/ca/p/eighth-day/regenerative-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/eighth-day/regenerative-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/eighth-day/regenerative-serum/for/mature-skin