# Derma E Retinol Concentrated Serum for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Derma E](https://lovi.care/skincare/sg/brands/derma-e)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- Offers moderate treatment for minimizing fine lines and wrinkles due to the presence of retinol and bakuchiol, which are suitable for your normal skin type and offer antioxidant activity and humectant action, respectively.
- While it provides general skincare benefits like hydration from sodium hyaluronate and glycerin, these are mostly supportive and not directly targeted at your main goal of pigmentation.
- The product is safe for your normal skin due to the absence of prohibited or harsh ingredients, posing no risks of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/oily-acne-prone-skin): High

## Key ingredients

Encapsulated Retinol, Bakuchiol, Punica Granatum Extract, Astaxanthin, Sodium Hyaluronate

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Astaxanthin-loaded polyhydroxybutyrate microbeads achieved 98.1% encapsulation efficiency with sustained release, reduced degradation by 2-fold compared to unencapsulated astaxanthin, and showed no cytotoxicity or skin irritation in human cells and tests. ([International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38072340/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Phenolic-rich pomegranate peel extract formulated into a serum and mask showed significantly better facial skin lightening efficacy than placebo in 30 volunteers over 28 days. ([Planta Medica, 2020](https://pubmed.ncbi.nlm.nih.gov/32428937/))
- Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26203268/))
- A topical microemulsion containing Punica granatum extract significantly reduced skin erythema and melanin compared to a placebo in healthy Asian subjects over 12 weeks. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25610348/))
- Oral astaxanthin supplementation significantly restored moisture content and improved elasticity but did not significantly decrease wrinkle depth compared to placebo in humans. ([Nutrients, 2021](https://pubmed.ncbi.nlm.nih.gov/34578794/))
- Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss. ([Acta Biochimica Polonica, 2012](https://pubmed.ncbi.nlm.nih.gov/22428137/))
- Twice-daily application of a novel topical antioxidant formulation safe, well-tolerated, and effective in improving overall skin quality, fine lines, wrinkles, radiance, and hyperpigmentation in 32 healthy female subjects over 12 weeks. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37608511/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on a very large amount of data, this serum is frequently praised for being gentle and suitable for sensitive skin, effectively improving texture and firmness. Many users report positive results without irritation, making it a good option for those new to retinol. Some users express frustration with the dropper design, and a few mention slow results or a sticky texture.

- Liked: Gentle on skin (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Good for beginners (sometimes noted)
- Disliked: Dropper design issues (sometimes noted)
- Disliked: Slow results (rarely noted)
- Disliked: Sticky texture (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the DERMA E Retinol Serum work for skin with dark spots?

This serum works moderately for dark spots, offering gentle treatment alongside general hydration. Products that fit this skin better need potent antioxidants and soothing ingredients that directly target dark spots without causing irritation.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this serum a good fit for skin with dark spots?

Retinol and bakuchiol help this serum fit skin with dark spots by offering moderate treatment, while sodium hyaluronate and glycerin provide supportive hydration. To be a better fit for this skin, a product of this type needs powerful antioxidants and soothing ingredients that specifically target dark spots without causing irritation.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Encapsulated Retinol do for skin with dark spots?

Encapsulated retinol helps fade dark spots and uneven skin tone while improving the look of sun-damaged skin. Using this ingredient may cause some initial dryness or stinging, but it works over time to reveal a smoother and more even complexion.
Sources: [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27050703/), [Cutis, 2008](https://pubmed.ncbi.nlm.nih.gov/18491487/)

### What does Bakuchiol do for skin with dark spots?

Bakuchiol helps reduce dark spots and uneven color, making skin look more balanced and even-toned. It works well on hyperpigmentation while being gentle, with a low likelihood of the scaling or stinging sometimes caused by other anti-aging ingredients.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/41562471/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in the evening routine after cleansing and before moisturizing. Treatments with actives are placed in the evening for simplicity and extra safety around sun exposure.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in the morning and this treatment at night. Because this product uses retinol and bakuchiol, separating them helps avoid stinging and keeps your skin calm.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### How often should I use this serum?

You can use this treatment in your evening routine, starting slowly and building up as your skin feels comfortable. This product needs targeted brightening ingredients and strong antioxidants for skin with dark spots.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts or clog your pores because it is free of heavy, pore-clogging ingredients. However, it may cause mild purging when you first start using it as the retinol helps speed up your skin cell turnover.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/sg/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — S$156.09 at Amazon
- [Neutrogena Rapid Tone Repair Vitamin C Serum](https://lovi.care/skincare/sg/p/neutrogena/rapid-tone-repair-20-vitamin-c-face-serum-capsules/for/dark-spots) — High fit — S$45.89 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dark-spots) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — S$30.40 at Amazon
- Hydrating Toner: [ma:nyo Bifida Biome Ampoule Toner](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/dark-spots) — Superior fit — S$36.16 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/sg/p/skin1004/centella-cream/for/dark-spots) — Superior fit — S$33.87 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Retinol, Bakuchiol, Astaxanthin, Sodium Hyaluronate, Punica Granatum Fruit Extract, Aspalathus Linearius Extract, Allantoin, Sodium Pca, Caprylic Capric Triglyceride, Carbomer, Leuconostoc Radish Root Ferment Filtrate, Potassium Hydroxide, Potassium Sorbate, Sodium Benzoate, Polysorbate 20, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/derma-e/retinol-concentrated-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/derma-e/retinol-concentrated-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/derma-e/retinol-concentrated-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/derma-e/retinol-concentrated-serum/for/dark-spots (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/derma-e/retinol-concentrated-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/derma-e/retinol-concentrated-serum/for/dark-spots