# Derma E Anti-Wrinkle Renewal Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Derma E](https://lovi.care/skincare/sg/brands/derma-e)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sg/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and anti-aging benefits for your combination skin, as glycerin and retinol hydrate and smooth texture, but these ingredients are not concentrated enough to directly address your acne and breakouts.
- Panthenol and Vitamin E provide general skincare benefits, but the formula lacks sufficient humectants to optimally hydrate drier areas of your combination skin.
- The product is generally safe for your combination skin, with a low risk of irritation from retinol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Bakuchiol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Carthamus Tinctorius Seed Oil

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Safflower oil body-human epidermal growth factor microgel emulsions mixed with xanthan gum enhance transdermal absorption, regulate inflammation, accelerate angiogenesis, and promote re-epithelialization and remodeling in full-layer skin wounds in rats. ([International Journal of Biological Macromolecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36126813/))

## Why other moisturizers fit acne-prone skin better

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Derma-E Anti-Wrinkle Renewal Cream work for acne-prone skin?

This cream is an average fit for your acne-prone skin, providing moderate moisture and smoothing texture with retinol and glycerin, but it lacks enough concentrated ingredients to directly target breakouts. A moisturizing treatment for acne-prone skin needs effective ingredients that handle blemishes and soothe the skin without causing irritation.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this cream a good fit for acne-prone skin?

Glycerin and retinol in this cream help hydrate and smooth your skin texture, while panthenol and vitamin E provide general care. However, because these ingredients are not concentrated enough to directly address breakouts, an acne-prone skin type needs a product with effective ingredients that target blemishes, provide excellent hydration and repair without irritation, and include soothing agents and peptides.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Retinol do for acne-prone skin?

Retinol helps acne-prone skin by speeding up cell turnover and clearing pores to reduce breakouts. It regulates skin growth and fights inflammation, though it may cause some mild peeling or stinging when you first start using it.
Sources: [Journal of Drugs in Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35816067/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/28318351/)

### What does Bakuchiol do for acne-prone skin?

Bakuchiol helps clear acne-prone skin by reducing pimples and dark spots without the stinging and scaling often caused by stronger treatments. It works well to calm redness and is unlikely to irritate sensitive skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/), [Journal of Drugs in Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33683079/)

### Where does this cream go in a skincare routine for acne-prone skin?

This cream goes in the evening routine as a treatment step, applied after your cleanser and before your moisturizer. Acne-prone skin works best with products that contain targeted blemish-clearing active ingredients and lightweight hydrators to keep breakouts calm and pores clear.

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying vitamin C in the morning and this retinol-based cream at night to help smooth your skin texture without overwhelming it. This type of skin needs a targeted acne treatment with stronger anti-blemish ingredients and lightweight hydrators to keep breakouts clear while managing combination dryness.

### How often should I use this cream?

You can use this moisturizing treatment twice daily to help smooth texture and hydrate your skin. Regular daily application is unlikely to cause irritation and may improve skin dryness and fine lines over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is generally safe for acne-prone skin, but because it offers only moderate moisture and lacks concentrated ingredients to directly target breakouts, it may not be the best fit. An ideal product for this skin needs lighter hydrators and targeted blemish-fighting ingredients to keep pores clear and calm.

### Can I use this cream around the eyes or on my body?

This cream is safe to use on the body and around the eyes, as its gentle formula carries a low risk of irritation. However, because skin thickness and sensitivity vary across body regions, you should always test a small area first to ensure good personal tolerance.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/sg/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — S$41.73 at Amazon
- [LANEIGE Water Bank Moisture Cream](https://lovi.care/skincare/sg/p/laneige/water-bank-moisture-cream/for/acne-prone-skin) — Average fit — S$38.31 at Amazon
- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/sg/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin) — Average fit — S$37.42 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — S$30.40 at Amazon
- Hydrating Toner: [TROIAREUKE H+Cocktail Purifying Ampoule Toner](https://lovi.care/skincare/sg/p/troiareuke/h-cocktail-purifying-ampoule-toner/for/acne-prone-skin) — Superior fit — S$168.51 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/sg/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — S$36.14 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Carthamus Tinctorius Seed Oil, Stearic Acid, Glycerin, Glyceryl Stearate Se, Cetyl Alcohol, Microcrystalline Cellulose, Cellulose Gum, Persea Gratissima Oil Avocado Oil, Sesamum Indicum Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Bakuchiol, Retinol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Allantoin, Phenoxyethanol, Ethylhexylglycerin, Oils
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin