# CLEARSTEM CELLRENEW Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [CLEARSTEM](https://lovi.care/skincare/sg/brands/clearstem)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum utilizes antioxidants and Camellia Sinensis to provide moderate anti-aging effects and protect against environmental stressors.
- The inclusion of Sodium Hyaluronate offers excellent hydration, further complementing the product's benefits for your wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Aloe Barbadensis.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Ganoderma Lucidum, Bio-Available Collagen Cells Stem, Antioxidants, Curcuma Longa

## What the research says

- Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone. ([Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Ferulic acid exhibits low toxicity, diverse physiological functions including antioxidant and anti-inflammatory effects, and protects skin structures, though its application is limited by rapid oxidation. ([Skin Pharmacology and Physiology, 2018](https://pubmed.ncbi.nlm.nih.gov/30235459/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of soap enriched with Ganoderma lucidum and goat's milk for 3 days resulted in almost complete regression of annular cutaneous sarcoidosis lesions in a 44-year-old male patient. ([Dermatology and Therapy, 2016](https://pubmed.ncbi.nlm.nih.gov/26868374/))
- Ganoderma lucidum polysaccharides at concentrations of 10, 20, and 40 ΓΖg/mL significantly increased fibroblast viability, migration, and CICP and TGF-Β1 expression compared to the control group, and external use in mice significantly increased wound healing rates and reduced healing time. ([Chinese Journal of Integrative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30552545/))
- Ethanolic extracts of Ganoderma lucidum rich in triterpenoids and phenolic acids exhibit antioxidant, anti-inflammatory, antityrosinase, antimicrobial, and cytotoxic effects, and can be successfully incorporated into topical cosmeceutical formulations while preserving their bioactivities. ([Food and Chemical Toxicology, 2017](https://pubmed.ncbi.nlm.nih.gov/28760544/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Based on a very large amount of data, users with acne-prone, sensitive, and reactive skin highly praise this product for calming inflammation, improving hydration, and supporting skin barrier repair. Many report smoother texture and reduced redness. Some users note it is a gentle, long-term support product rather than an overnight solution for deep-seated skin concerns.

- Liked: Acne-safe formula (mostly mentioned)
- Liked: Calms inflammation (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Insufficient for severe acne (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes CLEARstem CELLRENEW Serum a great fit for mature skin?

This serum is a great fit for mature skin because it uses antioxidants and Camellia Sinensis to protect against daily environmental stress and smooth out fine lines. It also includes Sodium Hyaluronate to give your skin deep hydration, while soothing ingredients like Aloe Barbadensis keep your skin calm with no irritation.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because antioxidants and Camellia Sinensis help protect against environmental stressors while providing moderate anti-aging effects. Additionally, Sodium Hyaluronate offers deep hydration to help smooth out the look of fine lines and wrinkles. Soothing components like Aloe Barbadensis keep your skin calm with an excellent safety profile.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Reishi Mushroom Extract do for mature skin?

Reishi mushroom extract helps care for mature skin by fighting oxidative stress and protecting against the effects of aging. It may reduce the look of deep lines while keeping the skin smooth and calm.
Sources: [Fitoterapia, 2025](https://pubmed.ncbi.nlm.nih.gov/40381851/), [Advances in Experimental Medicine and Biology, 2019](https://pubmed.ncbi.nlm.nih.gov/31777026/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Using antioxidant serums in a daily routine helps improve overall signs of aging and brightness.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to deliver antioxidants and hydration, followed by your retinol product. This approach is unlikely to cause irritation because the serum contains soothing ingredients like Aloe Barbadensis and lacks harsh components.

### How often should I use this serum?

You can use this serum in your evening routine, applying it after your cleanser and toner and before your moisturizer. It is very gentle and safe for daily use, helping to keep your skin hydrated and protected.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because it leaves out harsh ingredients and includes soothing aloe. It has a very safe profile, making it a gentle addition to your routine.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Antioxidants, Camellia Sinensis, Sodium Hyaluronate, Ganoderma Lucidum, Curcuma Longa, Trifolium Pratense, Peppermint Essence, Curcuma Extract, Aloe Barbadensis, Panthenol B5, Bio-Available Collagen Cells Stem, Kunzea Pomifera Fruit Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clearstem/cellrenew-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clearstem/cellrenew-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/clearstem/cellrenew-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/clearstem/cellrenew-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/clearstem/cellrenew-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/clearstem/cellrenew-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/clearstem/cellrenew-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/clearstem/cellrenew-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clearstem/cellrenew-serum/for/mature-skin