# BY ECOM Heartleaf Ampoule for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: BY ECOM
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- This product offers high suitability for your normal skin, with Glycerin and Sodium Hyaluronate providing excellent humectant action to maintain hydration. Additionally, Houttuynia Cordata Extract and Willow Bark Extract effectively target blemishes and decongest pores, addressing acne concerns.
- Water-Soluble Collagen and Sh-Oligopeptide-1 are included to promote collagen synthesis and skin regeneration, which is beneficial for your goal of reducing wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing components like Houttuynia Cordata Extract and Beta-Glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Heartleaf Extract, Sodium Hyaluronate, Glycerin, Centella Asiatica Extract, Curcuma Longa Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Users with oily and acne-prone skin frequently report that this ampoule effectively soothes inflammation and provides a cooling sensation. A moderate number of users also find it hydrating and notice some pore refining effects. A significant minority of reviewers mention a sticky finish and a strong alcohol scent, with some experiencing irritation or breakouts. Results for pore shrinking are mixed.

- Liked: Hydrating texture (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Liked: Aesthetic packaging (sometimes noted)
- Liked: Pore refining (sometimes noted)
- Disliked: Alcohol scent (sometimes noted)
- Disliked: Pore claims weak (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BY ECOM Heartleaf Ampoule a great fit for mature skin?

BY ECOM Heartleaf Ampoule is a great fit for mature skin because Water-Soluble Collagen and Sh-Oligopeptide-1 promote collagen synthesis and skin regeneration to help reduce wrinkles and fine lines. Additionally, ingredients like Glycerin and Sodium Hyaluronate provide deep hydration while soothing components ensure an excellent safety profile without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Which ingredients make this serum a good fit for mature skin?

Water-Soluble Collagen and Sh-Oligopeptide-1 make this serum a great fit for mature skin by helping promote skin regeneration and reduce wrinkles and fine lines. Glycerin and Sodium Hyaluronate also support this skin by maintaining deep hydration.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Heartleaf Extract do for mature skin?

Heartleaf Extract helps calm mature skin and protects it from daily stress by fighting off harmful free radicals and reducing redness. Studies show it supports skin health through strong antioxidant and anti-inflammatory properties.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39683560/), [Free Radical Biology & Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41242472/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does it go in a skincare routine for mature skin?

This product is used as an evening treatment after cleansing and toning, and before moisturizing. Putting this step in your evening routine keeps things simple and gives you extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and following with your retinol product, or by using them on alternating nights to keep your skin calm. Glycerin and Sodium Hyaluronate help keep your skin hydrated and comfortable when using active ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

Use this treatment in your evening routine. It contains ingredients like Water-Soluble Collagen and Sh-Oligopeptide-1 that help support your mature skin.

### Can it clog pores, cause breakouts or purging for mature skin?

BY ECOM Heartleaf Ampoule is unlikely to clog pores or cause breakouts for mature skin. Its formulation features ingredients that help keep pores clear, and it has an excellent safety profile with soothing components that minimize the risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Houttuynia Cordata Extract, Methylpropanediol, Butylene Glycol, Glycerin, 2-Hexanediol, Cyclohexasiloxane, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Lemon Fruit Extract, Monarda Didyma Leaf Extract, Citrus Aurantium Dulcis Fruit Extract, Anthemis Nobilis Flower Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Pteris Multifida Extract, Cynara Scolymus Leaf Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Chestnut Shell Extract, Piper Methysticum Stem Extract Root Leaf, Panax Ginseng Extract Berry, Corallina Officinalis Extract, Willow Bark Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Paeonia Albiflora Root Extract, Cnidium Officinale Root Extract, Pueraria Thunbergiana Root Extract, Portulaca Oleracea Extract, Enantia Chlorantha Bark Extract, Persea Gratissima Fruit Extract Avocado Fruit Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Water-Soluble Collagen, Aloe Barbadensis Leaf Juice, Sh-Polypeptide-19, Ammonium Acryloyldimethyltaurate Vp Copolymer, Xanthan Gum, Water, Carbomer, Fructooligosaccharides, Beta-Glucan, Disodium Edta, Tromethamine, Polyquaternium-51, Hydrolyzed Hyaluronic Acid, Alcohol, Lecithin, Pistacia Lentiscus Gum, Maltodextrin, Sodium Phosphate, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Oleanolic Acid, Ethylhexylglycerin, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/by-ecom/heartleaf-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/by-ecom/heartleaf-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/by-ecom/heartleaf-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/by-ecom/heartleaf-ampoule/for/mature-skin