Biossance Squalane + Probiotic Gel Moisturizer for oily acne-prone skin
Squalane
Probiotics
Glycerin
Lactococcus Lysate Ferment
Zingiber Officinale Root Extract
High
- HighOily Skin Fit
- HighEffectiveness
- HighSafety
A great choice for oily acne-prone skin; a few moisturizers fit it even better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This formulation is highly suitable for your oily skin, with squalane and lactococcus lysate ferment providing emollient action and supporting barrier repair to help manage oiliness.
- It offers moderate benefits for your acne, blemishes, and breakouts due to Lactococcus Lysate Ferment and Lepidium Sativum Extract Sprout, which support skin barrier function and provide antioxidant effects.
- The product is safe for your skin, as it contains soothing ingredients like allantoin and bisabolol and lacks harsh or prohibited ingredients.
How to apply
- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
People Say
★4.5Overall rating based on 2.3k+ reviewsBased on a very large amount of data, this lightweight gel moisturizer is highly recommended for oily, combination, and sensitive skin types, effectively hydrating without pore clogging and visibly reducing redness. However, a significant number of recent reviews indicate dissatisfaction with a formula change, noting a stickier texture and less pleasant scent compared to the original. Dry skin types may find it insufficient for hydration, and some users express concerns about the price point. A small number of users have reported irritation or breakouts.
Highlights
Lightweight & fast absorbing Mostly Mentioned
- “absorbs instantly”
- “feels like water”
- “zero greasy residue”
- “perfect for humid weather”
Balances oily skin Often Mentioned
- “controls my oil”
- “perfect balance”
- “doesn't clog pores”
- “matte but hydrated”
Calms redness & irritation Often Mentioned
- “redness vanished overnight”
- “calms angry skin”
- “instant cooling effect”
Reformulation complaints Often Mentioned
- “new formula is sticky”
- “smells terrible now”
- “too thick”
- “ruined a perfect product”
Excellent makeup base Sometimes Noted
- “makeup glides on”
- “no pilling under sunscreen”
- “acts like a primer”
- “smooth finish”
Not hydrating enough Sometimes Noted
- “skin felt tight”
- “need a second layer”
- “too light for dry skin”
- “not enough moisture”
Price point Sometimes Noted
- “way too expensive”
- “pricey for a basic gel”
- “jar is small”
- “not worth the money”
Irritation and breakouts Rarely Noted
- “burned my face”
- “caused cystic acne”
- “stung upon application”
- “broke me out”
Sources: lovi.care, biossance.com, sephora.com, influenster.com, reddit.com, and more
Questions and answers
What makes Biossance Squalane + Probiotic Gel Moisturizer a great fit for oily acne-prone skin?
This moisturizer is a great fit for your oily skin because squalane and lactococcus lysate ferment help manage oiliness by softening the skin and supporting barrier repair. It also helps with blemishes and breakouts while keeping your skin calm with soothing ingredients like allantoin and bisabolol.
Journal of Cosmetic Dermatology, 2023Journal of Nanobiotechnology, 2025
Which ingredients make this cream a good fit for oily acne-prone skin?
Squalane and lactococcus lysate ferment help manage oiliness by keeping your skin soft and supporting barrier repair, while lactococcus lysate ferment and lepidium sativum extract sprout provide antioxidant benefits for your breakouts. It is also safe for your skin because it includes soothing ingredients like allantoin and bisabolol without harsh additives.
Journal of Cosmetic Dermatology, 2023Journal of Nanobiotechnology, 2025
What does Squalane do for oily acne-prone skin?
Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
What do Probiotics do for oily acne-prone skin?
Probiotics help calm oily acne-prone skin by reducing pimples, decreasing swelling, and balancing the skin bacteria. They may also improve skin barrier function and reduce redness with fewer side effects than traditional treatments.
Journal of Experimental Pharmacology, 2025Journal of Cosmetic Dermatology, 2022
Where does it go in a skincare routine for oily acne-prone skin?
This moisturizer goes after your hydrating toner in the morning and after your treatment step in the evening. It provides a great fit for your oily skin by helping to manage oiliness and offering soothing benefits without harsh ingredients.
Can I use this cream with retinol, and in what order?
You can use this moisturizer with retinol by applying the cream after your retinol treatment to help soothe your skin and keep it comfortable. Using a barrier-supporting moisturizer alongside active treatments is unlikely to cause irritation and may help your skin tolerate the routine better.
How often should I use it?
This moisturizer is a great fit for your oily, acne-prone skin and can be used daily as part of your morning and evening routine. Using it regularly helps manage oiliness, keeps your skin calm, and supports your skin barrier without clogging pores.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?
This cream is unlikely to clog pores or cause breakouts for your oily acne-prone skin, as it features soothing ingredients and a safe profile that helps manage oiliness. Reviewers rarely report irritation or breakouts, and it includes ingredients that support your skin barrier and provide antioxidant effects.
Journal of Cosmetic Dermatology, 2023Journal of Nanobiotechnology, 2025
Can I use it around the eyes or on my body?
This moisturizer is safe and gentle for use on your body, but it is not specifically tested for the very thin skin around the eyes.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities.
Journal of Nanobiotechnology, 2025Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Topical application of sulforaphane-rich broccoli sprout extracts reduced UVR-induced erythema by a mean of 37.7% in six human subjects.
Proceedings of the National Academy of Sciences of the United States of America, 2007Pre-treatment with sulforaphane and phenylethyl isothiocyanate significantly counteracted UVR-induced increases in apoptosis and decreases in catalase in human skin by inducing Nrf2-dependent antioxidant pathways.
Pharmacological Research, 2013Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001A 1-year clinical study on human facial skin demonstrated that Zingiber officinale (L.) Rose extract inhibits the UV-induced decrease in skin elasticity and prevents or improves wrinkle formation around the eye.
Archives of Dermatological Research, 2008Ginger extract transethosomal hydrogel improved skin permeability, sustained drug release, and exhibited significant inhibition of edema swelling along with reduced reactive oxygen species and prostaglandin E2 compared to free ginger extract hydrogel and ketoprofen gel in a rat-paw edema model.
International Journal of Nanomedicine, 2023Topical delivery of ginger extract-loaded nanoemulsions significantly reduced arthritic symptoms, paw edema inhibition by 27.7%, and inflammatory cytokines in RA-induced rats compared to the negative control.
Journal of Pharmaceutical Sciences, 2023
Ingredients
Water, Squalane, Glycerin, Dimethicone, Pentylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Lactococcus Lysate Ferment, Caprylic Capric Triglyceride, Phenoxyethanol, Caprylyl Glycol, Dimethiconol, Chondrus Crispus Extract, Allantoin, Bisabolol, Glycine Soja Soybean Sterols, Linoleic Acid, Sodium Phytate, Lecithin, Sodium Hydroxide, Sodium Hyaluronate, Lactic Acid, Lepidium Sativum Extract Sprout, Sodium Chloride, Sodium Benzoate, Citric Acid, Zingiber Officinale Root Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.