# Biologique Recherche Lotion P50V for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Biologique Recherche](https://lovi.care/skincare/sg/brands/biologique-recherche)
Category: [Toners](https://lovi.care/skincare/sg/best/toners)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other toners fit it better.

## Why this fit

- Offers moderate exfoliation for your normal skin due to gluconolactone and lactic acid, which gently smooth texture and decongest pores, but lacks specialized ingredients for significant anti-aging effects on wrinkles and fine lines.
- The presence of niacinamide and yeast extract provides soothing benefits, while the mild keratolytic action of gluconolactone and lactic acid is supportive for your skin type.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/oily-acne-prone-skin): Superior

## Key ingredients

Gluconolactone, Niacinamide, Salicylic Acid, Lactic Acid, Cider Vinegar

## What the research says

- Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods. ([Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/))
- Gluconolactone and tartaric acid significantly lower transepidermal water loss and erythema after sodium lauryl sulphate challenge compared to vehicle, untreated control, and glycolic acid in healthy subjects. ([The British Journal of Dermatology, 1997](https://pubmed.ncbi.nlm.nih.gov/9470910/))
- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Gel formulations based on orange and sweet basil essential oils combined with acetic acid achieved up to 75% clearance of acne lesions in 28 volunteer patients with good stability and minimal, transient side effects. ([Biomedica, 2012](https://pubmed.ncbi.nlm.nih.gov/23235794/))

## Why other toners fit mature skin better

- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- Topical Tasmannia lanceolata extract reduced skin roughness, increased firmness, dermal density, and thickness of stabilized stretch marks compared to placebo in 29 women over 8 weeks, alongside increased pro-collagen I, elastin, and TGF-beta concentrations in ex vivo human skin explants. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33048421/))
- Topical application of a cream containing 4% Saussurea lappa extract significantly improved skin roughness, scaliness, wrinkles, and smoothness in healthy human subjects after 30, 60, and 90 days of continuous use compared to baseline. ([Pakistan Journal of Pharmaceutical Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29105631/))

## What reviewers say

Users consistently describe this toner as a "facial in a bottle" specifically suited for mature, dry, or "devitalized" skin due to its vitamin-enriched formula. While gentler than the original P50, it is highly praised for effectively resurfacing texture and creating a "glass skin" glow without stripping moisture, though the application process requires tolerance for its potent scent and sensation.

- Liked: Radiant glow (mostly mentioned)
- Disliked: Unpleasant scent (mostly mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Non-drying/balancing (sometimes noted)
- Liked: Pore refinement (sometimes noted)
- Disliked: Initial irritation (sometimes noted)
- Disliked: Hard to purchase (rarely noted)

## How to apply

- Use this exfoliating toner as part of your PM routine once a week to start , then increase frequency carefully if your skin feels comfortable.
- Apply this product after cleansing and before your moisturizer to ensure it works effectively.
- Gently press 2-3 drops of the exfoliating toner into your skin and let it absorb fully ⏳.
- Apply the exfoliating toner on clean, dry skin for the best results since your skin is normal and not sensitive.
- Avoid the sensitive eye area and always use SPF daily while using exfoliating active ingredients.
- Video: https://storage.pora.ai/020cca37b222f917c1e8d86638215d98.mp4

## Questions and answers

### How well does Biologique Recherche Lotion P50V work for mature skin?

Biologique Recherche Lotion P50V offers an average fit for mature skin, working to gently smooth texture and clear pores while lacking specialized anti-aging ingredients for significant help with wrinkles and fine lines. Products of this type need effective exfoliating ingredients that smooth texture and reduce wrinkles, paired with soothing and hydrating components for optimal results.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this toner a good fit for mature skin?

Niacinamide and yeast extract make this toner a good fit for mature skin by helping calm the skin and support its barrier. To work best for mature skin, a product of this type needs specialized anti-aging ingredients that target wrinkles and fine lines.
Sources: [Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Gluconolactone do for mature skin?

Gluconolactone helps smooth, plump, and brighten mature skin while keeping it well tolerated and comfortable. This ingredient provides antiaging benefits comparable to traditional alpha-hydroxyacids while being much gentler on sensitive skin.
Sources: [Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15002657/), [Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15002656/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this toner go in a skincare routine for mature skin?

This exfoliating toner goes in the evening routine after cleansing. Mature skin needing this type of product also benefits from targeted anti-aging ingredients like retinoids or peptides to help smooth wrinkles and fine lines.

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol by applying the toner first after cleansing, waiting for it to dry, and then following with your retinol. Because this toner works for mature skin but lacks specialized anti-aging ingredients for wrinkles, a mature skin routine also needs dedicated anti-aging ingredients like peptides, retinoids, or antioxidant serums.

### How often should I use this toner?

Start using this toner once a week, and if your skin handles it well and you see good results, you can carefully use it more often. A product of this type for mature skin needs specialized anti-aging ingredients that target wrinkles and fine lines.

### Can this toner clog pores, cause breakouts or purging for mature skin?

This exfoliating toner is unlikely to clog pores and instead helps clear them for mature skin, though it may cause some initial irritation. It offers gentle smoothing with acids, but this skin type needs targeted anti-aging ingredients like retinol or peptides to effectively address wrinkles and fine lines.

### Is this toner fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Missha Skin Peeling Pad](https://lovi.care/skincare/sg/p/missha/skin-peeling-pad/for/mature-skin) — High fit — S$38.65 at Amazon
- [ANUA BHA 2% Gentle Exfoliating Toner](https://lovi.care/skincare/sg/p/anua/bha-2-gentle-exfoliating-toner/for/mature-skin) — High fit — S$26.97 at YesStyle

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/mature-skin) — Superior fit — S$39.68 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Gluconolactone, Glycerin, Propylene Glycol, Niacinamide, Lactic Acid, Ethoxydiglycol, Vinegar, Magnesium Chloride, Citric Acid, Malic Acid, Phytic Acid, Spongilla Lacustris Spicule Extract, Yeast Extract, Horseradish Root Extract, Capsicum Frutescens Fruit Extract, Juglans Regia Seed Extract, Arctium Lappa Root Extract, Sulfur, Sodium Salicylate, Salicylic Acid, Sorbitol, Phenoxyethanol, Sodium Metabisulfite, Sodium Benzoate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biologique-recherche/lotion-p50v/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biologique-recherche/lotion-p50v/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/biologique-recherche/lotion-p50v/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/biologique-recherche/lotion-p50v/for/mature-skin
- France: https://lovi.care/skincare/fr/p/biologique-recherche/lotion-p50v/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/biologique-recherche/lotion-p50v/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/biologique-recherche/lotion-p50v/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/biologique-recherche/lotion-p50v/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/biologique-recherche/lotion-p50v/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/biologique-recherche/lotion-p50v/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/biologique-recherche/lotion-p50v/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/biologique-recherche/lotion-p50v/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biologique-recherche/lotion-p50v/for/mature-skin