BIOEFFECT EGF Serum for mature skin
Rh-Oligopeptide-1
Glycerin
Sodium Hyaluronate
Hordeum Vulgare Seed Extract
Tromethamine
Superior
- HighNormal Skin Fit
- SuperiorEffectiveness
- ExcellentSafety
One of the best serums for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin, this serum's Rh-Oligopeptide-1 and Barley Sh-Oligopeptide-1 promote significant skin regeneration to effectively minimize fine lines and wrinkles.
- Glycerin and Sodium Hyaluronate further enhance hydration and smoothness, supporting the plumping effects for your skin.
- The formula is safe for your skin, containing no harsh ingredients and featuring soothing components like Glycerin and Sodium Hyaluronate.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.7Overall rating based on 600+ reviewsUsers with dry, mature, or dehydrated skin highly praise this serum for its deep hydration, plumping effects, and ability to reduce fine lines, resulting in a radiant complexion. Some users with oily or combination skin find the texture sticky or heavy.
Highlights
Hydrating and plumping Mostly Mentioned
- “Gives the skin an instant hydration boost! It's also great for plumping up the skin.”
- “It felt hydrating and plumping.”
- “Keeps my skin hydrated and plump.”
- “Thrilled with the glow and how well moisturized and smooth my skin looks.”
Radiant glow Often Mentioned
- “Gives my 62-year-old skin a beautiful glow!”
- “Skin looks radiant and is more resilient.”
- “Complexion has never looked more radiant or even-toned.”
- “As soon as the serum penetrates my skin, you can see the glow immediately.”
Reduces fine lines Often Mentioned
- “Visible minimizing effect on lines.”
- “Reduces the appearance of fine lines.”
- “Deep wrinkle under my eye that has pretty much disappeared!”
- “Visible improvement in the lines on my forehead.”
Expensive product Often Mentioned
- “Pity that it's so expensive, I'd definitely repurchase.”
- “Not the best for this price.”
- “Yes, it's an expensive product.”
- “Definitely an investment purchase.”
Improves texture Sometimes Noted
- “Skin looks more plumped, smooth and hydrated.”
- “Real difference in the texture of skin.”
- “Plumper, smoother and I can get away with minimal makeup.”
- “Makes my skin look so much smoother, even-toned and brighter.”
Sticky texture Sometimes Noted
- “It feels a bit sticky on the skin.”
- “Can still feel sticky on my skin.”
- “It feels like a film on my skin.”
- “Not absorbing during the night.”
Too heavy Rarely Noted
- “Might be too much for some skin types, especially during the warmer weather.”
- “Almost a little oily.”
- “I put it in the evening and it is not absorbing.”
Sources: lovi.care, dermstore.com, cultbeauty.com, bioeffect.com, beauty-detective.com, whowhatwear.com, and more
Questions and answers
What makes BIOEFFECT EGF Serum one of the best fits for mature skin?
This serum is one of the best fits for mature skin because its Rh-Oligopeptide-1 and Barley Sh-Oligopeptide-1 help promote significant skin regeneration to minimize fine lines and wrinkles. Glycerin and Sodium Hyaluronate further enhance hydration and smoothness to support plumping effects.
Dermatologic Therapy, 2022Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit because Rh-Oligopeptide-1 and Barley Sh-Oligopeptide-1 promote significant skin regeneration to effectively minimize fine lines and wrinkles. Glycerin and Sodium Hyaluronate further enhance hydration and smoothness, supporting plumping effects for your skin.
Dermatologic Therapy, 2022Clinical, Cosmetic and Investigational Dermatology, 2017
What does EGF do for mature skin?
For mature skin, epidermal growth factor helps smooth fine lines, improve firmness, and support a more youthful look by encouraging skin renewal. It works best when paired with ingredients that deeply hydrate and protect against moisture loss to keep the skin feeling soft and smooth.
Journal of Cosmetic Dermatology, 2013International Journal of Molecular Medicine, 2017
What does Glycerin do for mature skin?
Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
The British Journal of Dermatology, 2008Clinical, Cosmetic and Investigational Dermatology, 2017
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure.
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol by applying the serum first to help smooth and hydrate, followed by your retinol. The formula is safe and gentle, making it unlikely to cause irritation when paired with a retinoid.
Dermatologic Therapy, 2022Clinical, Cosmetic and Investigational Dermatology, 2017
How often should I use this serum?
Use this serum in the evening. This timing is best for simplicity and extra safety around sun exposure.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh ingredients and features soothing components like glycerin and sodium hyaluronate. The formula has a safe profile with a very low likelihood of feeling too heavy.
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.
Drug Delivery, 2017Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.
The New England Journal of Medicine, 1989Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.
Lasers in Surgery and Medicine, 2020Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.
The Journal of Clinical and Aesthetic Dermatology, 2022The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Lidocaine at 20% and lidocaine 10% with trometamol provided effective pain control comparable to lidocaine/prilocaine in healthy adults after a 60-minute exposure, while propylene glycol did not accelerate the onset of analgesia.
Journal of Pain Research, 2017A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks.
Journal of Cosmetic Dermatology, 2020Ketorolac tromethamine poloxamer hydrogel provided sufficient bioavailability to reach the site of action with anti-inflammatory efficacy and no visual skin irritation in volunteers.
Pharmaceutical Research, 2017
Ingredients
Glycerin, Water, Sodium Hyaluronate, Tromethamine, Sodium Chloride, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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