# BIOEFFECT EGF Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [BIOEFFECT](https://lovi.care/skincare/sg/brands/bioeffect)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Highly suitable for normal skin, this serum utilizes rh-oligopeptide-1 and barley sh-oligopeptide-1 to promote skin regeneration and address pigmentation concerns by supporting repair processes.
- Sodium hyaluronate and glycerin further enhance hydration and smoothness, complementing the regenerative effects for your normal skin.
- The product is safe for your normal skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/oily-acne-prone-skin): High

## Key ingredients

Rh-Oligopeptide-1, Glycerin, Sodium Hyaluronate, Hordeum Vulgare Seed Extract, Tromethamine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Lidocaine at 20% and lidocaine 10% with trometamol provided effective pain control comparable to lidocaine/prilocaine in healthy adults after a 60-minute exposure, while propylene glycol did not accelerate the onset of analgesia. ([Journal of Pain Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28546768/))
- A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31347768/))
- Ketorolac tromethamine poloxamer hydrogel provided sufficient bioavailability to reach the site of action with anti-inflammatory efficacy and no visual skin irritation in volunteers. ([Pharmaceutical Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28540502/))

## What reviewers say

Users with dry, mature, or dehydrated skin highly praise this serum for its deep hydration, plumping effects, and ability to reduce fine lines, resulting in a radiant complexion. Some users with oily or combination skin find the texture sticky or heavy.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Radiant glow (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Too heavy (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BIOEFFECT EGF Serum a great fit for skin with dark spots?

BIOEFFECT EGF Serum is a great fit because it uses rh-oligopeptide-1 and barley sh-oligopeptide-1 to help renew skin and fade dark spots by supporting natural repair processes. Glycerin and sodium hyaluronate further boost hydration to keep your skin smooth, and the formula is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is a great fit for skin with dark spots because it uses rh-oligopeptide-1 and barley sh-oligopeptide-1 to promote skin regeneration and address pigmentation by supporting repair processes. Additionally, sodium hyaluronate and glycerin help enhance hydration and keep your skin smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does EGF do for skin with dark spots?

Epidermal growth factor may help fade dark spots on some skin types, but results vary depending on the treatment and individual skin response. While some studies show it can help reduce dark spots and prevent discoloration after procedures, other research finds no significant difference compared to standard care.
Sources: [Dermatologic Surgery, 2015](https://pubmed.ncbi.nlm.nih.gov/25551327/), [Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/)

### What does Glycerin do for skin with dark spots?

Glycerin helps keep dry skin hydrated and supports a healthy skin barrier, which makes skin feel soft and smooth. While it does not directly fade dark spots on its own, it is often added to spot-fading products to keep the skin comfortable while other ingredients work.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/)

### Where does it go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine, applied after cleansing and before your moisturizer. Using it at night keeps things simple and helps avoid extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to support skin repair and smooth dark spots, followed by your retinol. This pairing helps keep your skin hydrated while addressing pigmentation, and it is unlikely to cause irritation since the formula lacks harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

Use this treatment in the evening as part of your routine. It is a great fit for your skin, and sodium hyaluronate and glycerin help keep your skin hydrated and smooth while supporting repair.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on skin with dark spots. It has a safe profile with no identified risks of irritation from harsh ingredients.

## Alternatives for skin with dark spots

- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/sg/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — S$156.09 at Amazon
- [Neutrogena Rapid Tone Repair Vitamin C Serum](https://lovi.care/skincare/sg/p/neutrogena/rapid-tone-repair-20-vitamin-c-face-serum-capsules/for/dark-spots) — High fit — S$45.89 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dark-spots) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — S$30.40 at Amazon
- Hydrating Toner: [ma:nyo Bifida Biome Ampoule Toner](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-ampoule-toner/for/dark-spots) — Superior fit — S$36.16 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/sg/p/skin1004/centella-cream/for/dark-spots) — Superior fit — S$33.87 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Water, Sodium Hyaluronate, Tromethamine, Sodium Chloride, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioeffect/egf-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/bioeffect/egf-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/bioeffect/egf-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/bioeffect/egf-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/bioeffect/egf-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/bioeffect/egf-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/bioeffect/egf-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/bioeffect/egf-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/bioeffect/egf-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/dark-spots (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioeffect/egf-serum/for/dark-spots