# AXIS-Y Spot The Difference Blemish Treatment for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [AXIS-Y](https://lovi.care/skincare/sg/brands/axis-y)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your oily skin, this treatment effectively addresses blemishes and breakouts with salicylic acid and glycolic acid, which decongest pores and offer moderate exfoliation. Niacinamide further aids in regulating oil production and reducing inflammation, complementing the actions of Centella Asiatica Extract and Beta-Glucan.
- The formula includes beneficial ingredients like rosemary oil and tea tree leaf extract, which provide additional anti-inflammatory and antimicrobial support for acne-prone skin.
- This product is safe for your skin, as it contains soothing agents and avoids harsh or irritating components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Niacinamide, Salicylic Acid Bha, Glycolic Acid Aha, 4-Terpineol, Ceramide Np

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Topical 5% tea tree oil gel significantly improved total acne lesions and acne severity index compared to placebo in 60 patients with mild to moderate acne vulgaris, showing 3.55 times and 5.75 times greater efficacy respectively. ([Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/))
- Tea tree oil nanoemulsion containing adapalene gel demonstrated significantly greater reductions in total, inflammatory, and non-inflammatory acne lesions as well as acne severity index compared to adapalene marketed gel in 100 patients with acne vulgaris over 12 weeks. ([Archives of Dermatological Research, 2022](https://pubmed.ncbi.nlm.nih.gov/34251536/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- A foam formulation of 2% 4-terpineol killed common ocular microorganisms within 60 seconds and at 14 and 28 days without causing skin or ocular irritation in human subjects. ([BMJ Open Ophthalmology, 2018](https://pubmed.ncbi.nlm.nih.gov/30123842/))
- Topical tea tree oil and terpinen-4-ol produce good clinical outcomes in the management of Demodex blepharitis. ([Cornea, 2022](https://pubmed.ncbi.nlm.nih.gov/34743107/))
- Topical treatment with Australian tea tree oil and terpinen-4-ol effectively moderates human demodicosis by lowering mite counts, relieving symptoms, and modulating the inflammatory immune response. ([Parasitology, 2018](https://pubmed.ncbi.nlm.nih.gov/29667560/))

## What reviewers say

Users with acne-prone, oily, and sensitive skin praise this lightweight gel for effectively reducing redness and calming active breakouts without drying out the skin. While many experience fast results and appreciate the hydrating ceramide capsules, some find the bottle size too small and note that it may take time to see significant changes on stubborn blemishes.

- Liked: Gentle & non-drying (mostly mentioned)
- Liked: Effective acne relief (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Small product size (often mentioned)
- Liked: Good for sensitive skin (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Absorption issues (rarely noted)
- Disliked: Scent/applicator (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes AXIS-Y Spot The Difference Blemish Treatment a great fit for oily acne-prone skin?

This treatment is a great fit because it uses salicylic acid and glycolic acid to clear out pores and gently exfoliate oily skin. Niacinamide helps balance oil and calm redness, while tea tree leaf extract and soothing plant extracts provide extra support for acne-prone skin.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Archives of Dermatological Research, 2022](https://pubmed.ncbi.nlm.nih.gov/34251536/)

### Which ingredients make this treatment a good fit for oily acne-prone skin?

Salicylic acid and glycolic acid help clear out clogged pores and gently exfoliate oily skin. Niacinamide helps control oil and calm redness, while tea tree leaf extract and Centella Asiatica extract provide extra soothing and antimicrobial support for breakouts.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Salicylic Acid do for oily acne-prone skin?

Salicylic acid helps clear breakouts and keeps oily skin balanced by reducing oil levels and calming inflammation. It is well suited for oily, acne-prone skin because it targets pimples while helping keep the skin hydrated and protected.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682377/), [Experimental Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30972839/)

### Where does this treatment go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine, applied after cleansing and before moisturizing. While it is placed in the evening for simplicity and extra safety around sun exposure, some treatments can also be used in the morning or twice a day.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol, but applying them in the same routine may be too harsh for your skin, so alternate nights or use one in the morning and the other at night. This helps prevent excessive irritation while still targeting breakouts effectively.

### How often should I use this treatment?

Use this treatment in the evening as part of your routine. Start by using it once a week, and if your oily skin handles it well, you can carefully use it more often.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Archives of Dermatological Research, 2022](https://pubmed.ncbi.nlm.nih.gov/34251536/)

### Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment is a great fit for your oily acne-prone skin because it uses salicylic acid and glycolic acid to clear out pores and manage breakouts without clogging them. It helps calm angry skin and is unlikely to cause irritation.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Clean & Clear Persa-Gel 10 Acne Medication](https://lovi.care/skincare/sg/p/clean-and-clear/persa-gel-10/for/oily-acne-prone-skin) — Superior fit — S$25.46 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — S$50.41 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — S$30.40 at Amazon
- Hydrating Toner: [TROIAREUKE H+Cocktail Purifying Ampoule Toner](https://lovi.care/skincare/sg/p/troiareuke/h-cocktail-purifying-ampoule-toner/for/oily-acne-prone-skin) — Superior fit — S$168.51 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/sg/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — S$41.48 at Amazon

## Where to buy

- YesStyle: S$13.29 (https://www.yesstyle.com/en/axis-y-spot-the-difference-blemish-treatment-15ml/info.html/pid.1109631779?curr=SGD&rco=SG)
Prices checked 13 Oct 2026.

## Ingredients

Water, Glycerin, Propanediol, 1,2-Hexanediol, Glycereth-26, Niacinamide, Caprylic Capric Triglyceride, Aloe Barbadensis Leaf Extract, Althaea Rosea Flower Extract, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Camellia Sinensis Leaf Extract, Monarda Didyma Leaf Extract, Hydrangea Macrophylla Leaf Extract, Mentha Aquatica Extract, Sasa Quelpaertensis Extract, Melaleuca Alternifolia Tree Leaf Extract, Melia Azadirachta Leaf Extract, Eclipta Prostrata Extract, Camphor Leaf Extract, Cryptomeria Japonica Leaf Extract, Pinus Pinaster Bud Extract Bark, Rosmarinus Officinalis Oil Leaf Rosemary Oil Leaf, Hydrogenated Lecithin, Chamaecyparis Obtusa Water, Trehalose, Octyldodeceth-16, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, C12-14 Pareth-12, Butylene Glycol, Xanthan Gum, Disodium Edta, Ceramide Np, Fructooligosaccharides, Beta-Glucan, Hydrolyzed Hyaluronic Acid, 4-Terpineol, Glycyrrhiza Glabra Root Rhizome Licorice Root Rhizome, Moringa Oleifera Seed Oil, Glycolic Acid, Salicylic Acid, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin
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- Singapore: https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin