# Avène Cleanance Comedomed Anti-Blemish Concentrate for dry skin

**Lovi Fit: Caution fit for dry skin.**
Dry Skin Fit: Low · Effectiveness: Average · Safety: Risky.

Page: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Avène](https://lovi.care/skincare/sg/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A poor match for dry skin; the serums alongside fit it better.

## Why this fit

- Offers moderate exfoliation for your dry skin due to the presence of isopropyl alcohol and silica, which can be drying and may not adequately support your skin barrier.
- The formula includes isopropyl alcohol and silybum marianum fruit extract to help reduce blemishes, providing moderate treatment for acne-prone skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin): Caution (this page)
- [Combination skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Avène Thermal Spring Water, Silybum Marianum Fruit Extract, Glycerin, Isopropyl Alcohol, Silica

## What the research says

- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers. ([The Journal of Bone and Joint Surgery. American Volume, 2005](https://pubmed.ncbi.nlm.nih.gov/15866960/))
- Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38826967/))
- Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis. ([Skinmed, 2016](https://pubmed.ncbi.nlm.nih.gov/27871345/))
- A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities. ([Antioxidants, 2020](https://pubmed.ncbi.nlm.nih.gov/32224894/))
- Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers. ([European Journal of Pharmaceutical Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/28546105/))
- Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18312388/))

## What reviewers say

Based on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Reduces blemishes (mostly mentioned)
- Disliked: Strong alcohol scent (mostly mentioned)
- Liked: Controls oil (often mentioned)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying or peeling (sometimes noted)
- Disliked: Initial skin purging (rarely noted)
- Disliked: Stinging sensation (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why does Lovi advise caution with Cleanance Comedomed Anti-Blemish Concentrate for dry skin?

This treatment offers moderate exfoliation that can be drying on dry skin and may not adequately support your skin barrier. A product for this skin needs soothing ingredients that provide significant hydration and support skin health without any risk of irritation, such as propolis, niacinamide, ceramides, vitamin C, bifida fermentation, and peptides.

### Which ingredients make this treatment a poor fit for dry skin?

Isopropyl alcohol and silica make this treatment a poor fit because they offer moderate exfoliation that can be drying and may not adequately support your dry skin barrier. To suit dry skin, a treatment of this type needs soothing ingredients, ceramides, niacinamide, or peptides that provide deep hydration and support skin health without any risk of irritation.

### What does Avène Thermal Spring Water do for dry skin?

Avene Thermal Spring Water helps calm dry skin by reducing redness and soothing irritation. Regular use may also improve skin comfort and reduce the feeling of tightness.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/)

### What does Milk Thistle Fruit Extract do for dry skin?

Milk thistle fruit extract helps soothe dry skin by calming redness and locking in moisture to keep your face feeling soft and smooth. It may also help protect against daily irritation and dryness with its antioxidant properties.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18254805/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23884490/)

### Where does this treatment go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though it requires caution on dry skin because it can be drying and may not adequately support your skin barrier. A product of this type for dry skin needs gentle, hydrating ingredients and barrier-supporting components like glycerin and soothing plant extracts.

### Can I use this treatment with retinol, and in what order?

Using this treatment with retinol on dry skin is not recommended because both products can dry out your skin and may harm your skin barrier. Instead, dry skin needs gentle, hydrating ingredients and rich moisturizers that soothe and protect the skin barrier while managing blemishes.

### How often should I use this treatment?

This treatment is a poor fit for your dry skin, so you should use it only once a week to see how your skin tolerates it. The drying ingredients in this formula may cause irritation and do not adequately support your skin barrier. A product for dry skin needs gentle ingredients like glycerin and soothing plant extracts to keep your skin soft and calm.

### Can this treatment clog pores, cause breakouts or purging for dry skin?

This treatment is unlikely to clog pores, but it may cause mild peeling or initial purging on dry skin because it contains isopropyl alcohol and silica. Dry skin needs gentle hydration and soothing ingredients like ceramides or hyaluronic acid to stay smooth and comfortable without drying out.

### Is this treatment fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (isopropyl alcohol).

## Alternatives for dry skin

- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — S$40.09 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — S$54.11 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-skin) — Superior fit — S$50.41 at Amazon

## Routine for dry skin

### AM

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — S$41.07 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon
- SPF: [Thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/sg/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — S$21.09 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — S$39.68 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sg/p/peach-and-lily/glass-skin-refining-serum/for/dry-skin) — Superior fit — S$63.44 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — S$39.68 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — S$25.06 at Amazon
- Nourishing Mask: [Mediheal Collagen Essential Mask](https://lovi.care/skincare/sg/p/mediheal/collagen-essential-mask/for/dry-skin) — Superior fit — S$62.94 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sg/p/peach-and-lily/glass-skin-refining-serum/for/dry-skin) — Superior fit — S$63.44 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — S$25.94 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin