# Avène Cleanance Comedomed Anti-Blemish Concentrate for dry sensitive skin

**Lovi Fit: Low fit for dry sensitive skin.**
Dry Skin Fit: Low · Effectiveness: High · Safety: Risky.

Page: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Avène](https://lovi.care/skincare/sg/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for dry sensitive skin; the serums alongside fit it better.

## Why this fit

- Offers moderate treatment for your acne-prone skin as isopropyl alcohol and silybum marianum fruit extract help reduce blemishes, though the isopropyl alcohol may worsen your dry and sensitive skin.
- Glycerin provides some hydration for your dry or flaky skin, but the formula lacks sufficient emollient ingredients to adequately support your skin barrier.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin): Low (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Avène Thermal Spring Water, Silybum Marianum Fruit Extract, Glycerin, Isopropyl Alcohol, Silica

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers. ([The Journal of Bone and Joint Surgery. American Volume, 2005](https://pubmed.ncbi.nlm.nih.gov/15866960/))
- Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38826967/))
- Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis. ([Skinmed, 2016](https://pubmed.ncbi.nlm.nih.gov/27871345/))
- A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities. ([Antioxidants, 2020](https://pubmed.ncbi.nlm.nih.gov/32224894/))
- Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers. ([European Journal of Pharmaceutical Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/28546105/))
- Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18312388/))

## Why other serums fit dry sensitive skin better

- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))
- Topical and oral vitamin E exhibited antitumorigenic, photoprotective, and skin barrier stabilizing properties in human skin. ([Molecular Aspects of Medicine, 2007](https://pubmed.ncbi.nlm.nih.gov/17719081/))

## What reviewers say

Based on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Reduces blemishes (mostly mentioned)
- Disliked: Strong alcohol scent (mostly mentioned)
- Liked: Controls oil (often mentioned)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying or peeling (sometimes noted)
- Disliked: Initial skin purging (rarely noted)
- Disliked: Stinging sensation (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is Avène Cleanance Comedomed Anti-Blemish Concentrate a weak match for dry sensitive skin?

This treatment is a weak match because the isopropyl alcohol in it may worsen your dry and sensitive skin, and it lacks sufficient rich moisturizing and nourishing ingredients to properly support your skin barrier. A product of this type needs effective hydrating and protecting ingredients like ceramides and vitamins to keep dry skin calm, soft, and smooth without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this treatment a poor fit for dry sensitive skin?

Isopropyl alcohol makes this treatment a poor fit because it may worsen dry and sensitive skin. A product for this skin needs rich hydrating and nourishing ingredients, such as ceramides and multiple forms of vitamin C, to support the skin barrier without irritation.

### What does Avène Thermal Spring Water do for dry sensitive skin?

Avène Thermal Spring Water helps calm red, irritated skin and reduces stinging and burning while keeping it soft and comfortable. It has a very safe profile for sensitive skin and supports moisture balance to relieve dryness.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/)

### What does Milk Thistle Fruit Extract do for dry sensitive skin?

Milk thistle fruit extract helps calm dry sensitive skin by easing redness and irritation. It supports the skin barrier with soothing properties that are gentle and well tolerated.
Sources: [International Immunopharmacology, 2024](https://pubmed.ncbi.nlm.nih.gov/39059101/)

### Where does this treatment go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine for dry sensitive skin, applied after a soothing toner and before a moisturizer. Because this product is a weak match for your skin, a product of this type needs rich moisturizing ingredients and skin-softening oils to keep dry skin calm and hydrated.

### Can I use this treatment with retinol, and in what order?

This treatment is a weak match for your dry and sensitive skin because its alcohol content may worsen dryness and irritation. A product of this type needs gentle blemish-reducing ingredients paired with rich, soothing moisturizers and barrier-protecting oils to keep dry skin comfortable.

### How often should I use this treatment?

This product is a weak match for your dry and sensitive skin because it contains drying ingredients that may worsen irritation and lacks enough softening components to protect your skin barrier. To safely treat your skin type, a product of this type needs rich moisturizing ingredients and barrier-protecting components like ceramides or plant oils.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this treatment clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to clog pores or cause breakouts, but it may cause drying or peeling on dry and sensitive skin because it contains isopropyl alcohol. A product for this skin needs rich moisturizing ingredients and protective oils to support the skin barrier while targeting blemishes.

### Is this treatment fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (isopropyl alcohol).

## Alternatives for dry sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/dry-sensitive-skin) — High fit — S$50.41 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin) — High fit — S$40.09 at Amazon
- [PCA Skin C&E Advanced with Hexylresorcinol and Silymarin](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-advanced/for/dry-sensitive-skin) — High fit — S$192.38 at Amazon

## Routine for dry sensitive skin

### AM

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Soothing Toner: [Mario Badescu Facial Spray with Aloe, Chamomile and Lavender](https://lovi.care/skincare/sg/p/mario-badescu/facial-spray-with-aloe-chamomile-and-lavender/for/dry-sensitive-skin) — High fit — S$34.52 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/sg/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — S$59.06 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/dry-sensitive-skin) — Superior fit — S$39.68 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Soothing Toner: [Mario Badescu Facial Spray with Aloe, Chamomile and Lavender](https://lovi.care/skincare/sg/p/mario-badescu/facial-spray-with-aloe-chamomile-and-lavender/for/dry-sensitive-skin) — High fit — S$34.52 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sg/p/peach-and-lily/glass-skin-refining-serum/for/dry-sensitive-skin) — Superior fit — S$63.44 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-sensitive-skin) — Superior fit — S$25.94 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sg/p/missha/ultra-hyalon-cleansing-cream/for/dry-sensitive-skin) — Superior fit — S$39.68 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/sg/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — S$25.06 at Amazon
- Nourishing Mask: [Pyunkang Yul Black Tea Revitalizing Mask Pack](https://lovi.care/skincare/sg/p/pyunkang-yul/black-tea-revitalizing-mask-pack/for/dry-sensitive-skin) — Superior fit — S$50.43 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sg/p/peach-and-lily/glass-skin-refining-serum/for/dry-sensitive-skin) — Superior fit — S$63.44 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/sg/p/d-alba/first-spray-serum/for/dry-sensitive-skin) — Superior fit — S$25.94 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin