# Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Brand: [Allies of Skin](https://lovi.care/skincare/sg/brands/allies-of-skin)
Category: [Serums and treatments](https://lovi.care/skincare/sg/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses wrinkles and fine lines with copper tripeptide-1 and ectoin, which promote skin repair and collagen stimulation while niacinamide and hyaluronic acid provide essential hydration.
- Panthenol and allantoin further support barrier resilience and offer soothing benefits, enhancing the overall efficacy for your skin concerns.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/oily-acne-prone-skin): High

## Key ingredients

Copper Tripeptide-1, Ectoin, Niacinamide, Hyaluronic Acid, Panthenol

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases. ([Inflammation Research, 2010](https://pubmed.ncbi.nlm.nih.gov/20703511/))
- Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37539499/))
- Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control. ([Biomedicines, 2026](https://pubmed.ncbi.nlm.nih.gov/42792808/))
- Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Users consistently report a healthier, more radiant complexion and smoother texture, though the high price point is frequently noted as the primary drawback.

- Liked: Calms redness (often mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Fast results (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Initial irritation (rarely noted)
- Disliked: Slow anti-aging results (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum a great fit for mature skin?

This serum is a great fit because copper tripeptide-1 and ectoin help smooth fine lines and promote skin repair, while niacinamide and hyaluronic acid provide essential moisture. Panthenol and allantoin further support your skin barrier and keep it calm, with a very low risk of irritation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because copper tripeptide-1 and ectoin help smooth wrinkles and fine lines while supporting skin repair. Niacinamide and hyaluronic acid also provide essential hydration, and panthenol and allantoin soothe the skin.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### What does Copper Tripeptide-1 do for mature skin?

Copper Tripeptide-1 helps improve mature skin by smoothing out fine lines and wrinkles while boosting firmness and elasticity. It also helps calm irritation, protects against daily damage, and supports a stronger skin barrier.
Sources: [Journal of Biomaterials Science. Polymer Edition, 2008](https://pubmed.ncbi.nlm.nih.gov/18644225/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### What does Ectoin do for mature skin?

For mature skin, ectoin helps keep skin hydrated and smooth while supporting firmness and protecting against everyday damage. It helps improve moisture levels and preserves collagen, which is especially beneficial since mature skin tends to become dry and lose its bounce.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41116229/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help repair and hydrate your skin, followed by your retinol. This approach is very unlikely to cause irritation because the formula is gentle and soothing.

### How often should I use this serum?

This serum works best when applied in your evening routine. Using it at night helps avoid any sun sensitivity and gives the copper tripeptide-1 and ectoin time to effectively support skin repair and smooth out fine lines.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Can it clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no heavy or harsh ingredients that typically trigger irritation or congestion. Its soothing components help maintain a gentle and safe profile for everyday use.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon
- [PCA Skin C&E Strength Max](https://lovi.care/skincare/sg/p/pca-skin/c-and-e-strength-max/for/mature-skin) — High fit — S$179.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sg/p/neogen-dermalogy/real-vitamin-c-serum/for/mature-skin) — High fit — S$50.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sg/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — S$30.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sg/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — S$41.07 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sg/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — S$110.01 at Amazon

## Where to buy

No store in Singapore has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Niacinamide, Copper Tripeptide-1, Ectoin, Hyaluronic Acid, Panthenol, Lactobacillus Ferment, Sodium Pca, Allantoin, Tocopherol Vitamin E, Sodium Ascorbyl Phosphate Ascorbic Acid, Phenoxyethanol, Ethylhexylglycerin, Caprylyl Glycol, Xanthan Gum, Carbomer, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/mature-skin