# Tretinoin and palmitoyl tripeptide-1 Page: https://lovi.care/skincare/sg/ingredients/tretinoin-and-palmitoyl-tripeptide-1 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore. Keep them apart Use them at different times of day by applying your peptide product in the morning and your [tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) at night. Using both strong ingredients at the same time can cause extra skin irritation and redness. You can prevent this by switching to a gentler retinoid or giving your skin more time between applications. - [All about tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) - [All about palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/palmitoyl-tripeptide-1) ### [Tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) products - [Retin-A Cream](https://lovi.care/skincare/sg/p/retin-a/cream/for/oily-skin) — High fit - [Tri-Luma Cream](https://lovi.care/skincare/sg/p/tri-luma/cream/for/dark-spots) — Average fit - [Musely The Spot Cream](https://lovi.care/skincare/sg/p/musely/the-spot-cream/for/mature-skin) — High fit - [Obagi Tretinoin Cream 0.05%](https://lovi.care/skincare/sg/p/obagi/tretinoin-cream-0-05/for/oily-skin) — High fit - [Taro Tretinoin Cream](https://lovi.care/skincare/sg/p/taro/tretinoin-cream/for/combination-skin) — High fit - [Mylan Tretinoin](https://lovi.care/skincare/sg/p/mylan/tretinoin/for/acne-prone-skin) — Average fit - [Curology Formula](https://lovi.care/skincare/sg/p/curology/formula/for/oily-skin) — High fit - [Menarini A-Ret Gel](https://lovi.care/skincare/sg/p/menarini/a-ret-gel/for/oily-skin) — High fit ### [Palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/palmitoyl-tripeptide-1) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit - [Medik8 Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit - [Shiseido Benefiance Wrinkle Smoothing Eye Cream](https://lovi.care/skincare/sg/p/shiseido/benefiance-wrinkle-smoothing-eye-cream/for/mature-skin) — High fit — [S$55.43 at YesStyle](https://www.yesstyle.com/en/shiseido-benefiance-wrinkle-smoothing-eye-cream-international-edition/info.html/pid.1137782181?curr=SGD&rco=SG) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit - [Alastin Skincare Regenerating Skin Nectar](https://lovi.care/skincare/sg/p/alastin-skincare/regenerating-skin-nectar/for/mature-skin) — Superior fit - [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/sg/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit - [ZO Skin Health Daily Power Defense](https://lovi.care/skincare/sg/p/zo-skin-health/daily-power-defense/for/oily-skin) — High fit - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/sg/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [Alastin Ultra Nourishing Moisturizer](https://lovi.care/skincare/sg/p/alastin/ultra-nourishing-moisturizer/for/dry-skin) — Superior fit - [DRMTLGY Needle-less Serum](https://lovi.care/skincare/sg/p/drmtlgy/needle-less-serum/for/dry-skin) — Superior fit — [S$94.18 at Amazon](https://www.amazon.sg/dp/B0CJK22LNX?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1) - [Valmont Prime Renewing Pack](https://lovi.care/skincare/sg/p/valmont/prime-renewing-pack/for/mature-skin) — High fit ## Questions and answers ### Can you use tretinoin and palmitoyl tripeptide-1 together? No, you should keep [tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) and [palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/palmitoyl-tripeptide-1) apart in your routine because combining them may increase irritation. Instead, alternate their usage by applying tretinoin in the evening and peptides in the morning. ### Which goes first, tretinoin or palmitoyl tripeptide-1? Keep tretinoin and palmitoyl tripeptide-1 apart by alternating your usage, applying your retinoid in the evening and peptides in the morning. Combining them in the same routine may increase skin irritation. ### Are tretinoin and palmitoyl tripeptide-1 good for sensitive skin? Keep tretinoin and palmitoyl tripeptide-1 apart in your routine because combining them may increase irritation on sensitive skin. Alternate their usage by applying your retinoid in the PM and peptides in the AM. ## Research on tretinoin and palmitoyl tripeptide-1 - [Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid)](https://pubmed.ncbi.nlm.nih.gov/8336752/) Tretinoin · The New England Journal of Medicine, 1993 - [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Tretinoin · Clinical, Cosmetic and Investigational Dermatology, 2020 - [Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study](https://pubmed.ncbi.nlm.nih.gov/34146120/) Tretinoin · Archives of Dermatological Research, 2022 - [Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/35620028/) Tretinoin · International Journal of Women's Dermatology, 2022 - [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015 - [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026 - [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026 ## Other combinations - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/sg/ingredients/tretinoin-and-bio-placenta-peptides) - Keep them apart: [Tretinoin and collagen peptide](https://lovi.care/skincare/sg/ingredients/tretinoin-and-collagen-peptide) - Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/sg/ingredients/tretinoin-and-copper-peptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/sg/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/sg/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/sg/ingredients/tretinoin-and-palmitoyl-pentapeptide-4) - Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/adapalene-and-palmitoyl-tripeptide-1) - Keep them apart: [Granactive retinoid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/granactive-retinoid-and-palmitoyl-tripeptide-1) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1) - Keep them apart: [Pro-retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/pro-retinol-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinal and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/retinal-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinoid blend and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/retinoid-blend-and-palmitoyl-tripeptide-1) - Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/retinol-and-palmitoyl-tripeptide-1) - Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/vitamin-a-and-palmitoyl-tripeptide-1) - Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/sg/ingredients/tretinoin-and-peptide-rich-plasma) - Keep them apart: [Tretinoin and triple peptide blend](https://lovi.care/skincare/sg/ingredients/tretinoin-and-triple-peptide-blend) - Work well together: [Liposome and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/liposome-and-palmitoyl-tripeptide-1) - Work well together: [Microcapsule and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/microcapsule-and-palmitoyl-tripeptide-1) - Depends on the strength: [Vitamin C and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/vitamin-c-and-palmitoyl-tripeptide-1) - Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/sg/ingredients/niacinamide-and-tretinoin) - Work well together: [Betaine and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/betaine-and-palmitoyl-tripeptide-1) - Work well together: [Glycerin and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/glycerin-and-palmitoyl-tripeptide-1) - Work well together: [Hyaluronic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid-and-palmitoyl-tripeptide-1) - Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/niacinamide-and-palmitoyl-tripeptide-1) - Work well together: [Panthenol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/panthenol-and-palmitoyl-tripeptide-1) - Work well together: [Bakuchiol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/bakuchiol-and-palmitoyl-tripeptide-1) - Work well together: [Arginine and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/arginine-and-palmitoyl-tripeptide-1) - Work well together: [GABA and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/gaba-and-palmitoyl-tripeptide-1) - Work well together: [Silk amino acids and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/silk-amino-acids-and-palmitoyl-tripeptide-1) - Work well together: [Taurine and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/taurine-and-palmitoyl-tripeptide-1) - Work well together: [Palmitoyl tripeptide-1 and theanine](https://lovi.care/skincare/sg/ingredients/palmitoyl-tripeptide-1-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-tripeptide-1) - Keep them apart: [Citric acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/citric-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Glycolic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/lactic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1) - Work well together: [Coenzyme Q10 and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/coenzyme-q10-and-palmitoyl-tripeptide-1) - Work well together: [Green tea and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/green-tea-and-palmitoyl-tripeptide-1) - Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/vitamin-e-and-palmitoyl-tripeptide-1) - Keep them apart: [AHA blend glycolic and citric acids and tretinoin](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-tretinoin) - Keep them apart: [Tretinoin and citric acid](https://lovi.care/skincare/sg/ingredients/tretinoin-and-citric-acid) - Keep them apart: [Glycolic acid and tretinoin](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-tretinoin) - Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/sg/ingredients/tretinoin-and-lactic-acid) - Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/sg/ingredients/tretinoin-and-mandelic-acid) - Work well together: [Beta-sitosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/beta-sitosterol-and-palmitoyl-tripeptide-1) - Work well together: [Ceramide-building complex and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex-and-palmitoyl-tripeptide-1) - Work well together: [Cholesterol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/cholesterol-and-palmitoyl-tripeptide-1) - Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1) - Work well together: [Phytosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/phytosterol-and-palmitoyl-tripeptide-1) - Work well together: [Squalene and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/squalene-and-palmitoyl-tripeptide-1) - Work well together: [Tri-ceramide complex and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/tri-ceramide-complex-and-palmitoyl-tripeptide-1) - Keep them apart: [Salicylic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/salicylic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Salicylic acid and tretinoin](https://lovi.care/skincare/sg/ingredients/salicylic-acid-and-tretinoin) - Keep them apart: [Vitamin C and tretinoin](https://lovi.care/skincare/sg/ingredients/vitamin-c-and-tretinoin) - Keep them apart: [Baking soda and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/baking-soda-and-palmitoyl-tripeptide-1) - Keep them apart: [Bleach and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/bleach-and-palmitoyl-tripeptide-1) - Keep them apart: [Potassium hydroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/potassium-hydroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Behenyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/behenyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Isopropyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/isopropyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Polyvinyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/polyvinyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Copper and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/copper-and-palmitoyl-tripeptide-1) - Keep them apart: [Benzoyl peroxide and tretinoin](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-tretinoin) - Keep them apart: [Benzoyl peroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Magnesium and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/magnesium-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/zinc-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc sulfate and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/zinc-sulfate-and-palmitoyl-tripeptide-1) - Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/protease-and-palmitoyl-tripeptide-1) - Keep them apart: [Superoxide dismutase and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/superoxide-dismutase-and-palmitoyl-tripeptide-1) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - United Kingdom: https://lovi.care/skincare/uk/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Ireland: https://lovi.care/skincare/ie/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Germany: https://lovi.care/skincare/de/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - France: https://lovi.care/skincare/fr/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Italy: https://lovi.care/skincare/it/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Netherlands: https://lovi.care/skincare/nl/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Spain: https://lovi.care/skincare/es/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Canada: https://lovi.care/skincare/ca/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Australia: https://lovi.care/skincare/au/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - Singapore: https://lovi.care/skincare/sg/ingredients/tretinoin-and-palmitoyl-tripeptide-1 (this page) - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/tretinoin-and-palmitoyl-tripeptide-1 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/tretinoin-and-palmitoyl-tripeptide-1