# Niacinamide and tretinoin

Page: https://lovi.care/skincare/sg/ingredients/niacinamide-and-tretinoin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Depends on the strength

Use them at different times of day, applying [niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide) in the morning and [tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) at night, to keep your skin calm. Using both at once can cause extra redness and dryness because they work hard on your skin at the same time. You can try a lower strength of tretinoin or wait a little longer between applying them.

[Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects](https://pubmed.ncbi.nlm.nih.gov/28318351/) [Why Topical Retinoids Are Mainstay of Therapy for Acne](https://pubmed.ncbi.nlm.nih.gov/28585191/)

- [All about niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide)
- [All about tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin)

### [Niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide) products

- [La Roche-Posay Toleriane Double Repair Face Moisturizer](https://lovi.care/skincare/sg/p/la-roche-posay/toleriane-double-repair-face-moisturizer/for/oily-acne-prone-skin) — High fit — [S$43.56 at Amazon](https://www.amazon.sg/dp/B01N9SPQHQ?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sg/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [S$30.40 at Amazon](https://www.amazon.sg/dp/B07RJ18VMF?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/sg/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [S$29.66 at Amazon](https://www.amazon.sg/dp/B099N3NM61?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/sg/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit
- [Dr. Althea 345 Relief Cream](https://lovi.care/skincare/sg/p/dr-althea/345-relief-cream/for/acne-prone-skin) — Superior fit — [S$29.47 at YesStyle](https://www.yesstyle.com/en/dr-althea-345-relief-cream-renewed-50ml/info.html/pid.1124698946?curr=SGD&rco=SG)
- [Biodance Bio-Collagen Real Deep Mask](https://lovi.care/skincare/sg/p/biodance/bio-collagen-real-deep-mask/for/mature-skin) — Superior fit — [S$33.59 at Amazon](https://www.amazon.sg/dp/B0HMNVW6QD?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/sg/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [S$39.91 at Amazon](https://www.amazon.sg/dp/B0011DNXC2?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/sg/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [S$28.62 at Amazon](https://www.amazon.sg/dp/B07XJ7XWLW?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/sg/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [S$28.30 at YesStyle](https://www.yesstyle.com/en/cerave-pm-facial-moisturising-lotion-for-normal-to-dry-skin-52ml/info.html/pid.1129717741?curr=SGD&rco=SG)
- [Medicube PDRN Pink Peptide Serum](https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [S$37.93 at Amazon](https://www.amazon.sg/dp/B0HMWFT2KG?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [CeraVe Renewing SA Cleanser](https://lovi.care/skincare/sg/p/cerave/renewing-sa-cleanser/for/oily-acne-prone-skin) — High fit — [S$28.59 at Amazon](https://www.amazon.sg/dp/B08CQ9T6KN?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Medicube Collagen Jelly Cream](https://lovi.care/skincare/sg/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [S$29.41 at YesStyle](https://www.yesstyle.com/en/medicube-collagen-jelly-cream-110ml/info.html/pid.1124066776?curr=SGD&rco=SG)

### [Tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) products

- [Retin-A Cream](https://lovi.care/skincare/sg/p/retin-a/cream/for/oily-skin) — High fit
- [Tri-Luma Cream](https://lovi.care/skincare/sg/p/tri-luma/cream/for/dark-spots) — Average fit
- [Obagi Tretinoin Cream 0.05%](https://lovi.care/skincare/sg/p/obagi/tretinoin-cream-0-05/for/oily-skin) — High fit
- [Taro Tretinoin Cream](https://lovi.care/skincare/sg/p/taro/tretinoin-cream/for/combination-skin) — High fit
- [Mylan Tretinoin](https://lovi.care/skincare/sg/p/mylan/tretinoin/for/acne-prone-skin) — Average fit
- [Curology Formula](https://lovi.care/skincare/sg/p/curology/formula/for/oily-skin) — High fit
- [Menarini A-Ret Gel](https://lovi.care/skincare/sg/p/menarini/a-ret-gel/for/oily-skin) — High fit

## Questions and answers

### Can you use niacinamide and tretinoin together?

Using [niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide) and [tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) together depends on the strength, so you should use niacinamide in the morning and your retinoid at night. Musely The Spot Cream contains both ingredients.

### Which goes first, niacinamide or tretinoin?

Using niacinamide and tretinoin depends on the strength, so you should use niacinamide in the morning and strong retinoids at night, or use Musely The Spot Cream. Separating them helps avoid the increased irritation that may happen when both activate cell turnover at the same time.

### Are niacinamide and tretinoin good for sensitive skin?

Using niacinamide and tretinoin together depends on the strength, and they may cause irritation if not separated into morning and evening routines. Musely The Spot Cream contains both ingredients.

## Research on niacinamide and tretinoin

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid)](https://pubmed.ncbi.nlm.nih.gov/8336752/) Tretinoin · The New England Journal of Medicine, 1993
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Tretinoin · Clinical, Cosmetic and Investigational Dermatology, 2020
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study](https://pubmed.ncbi.nlm.nih.gov/34146120/) Tretinoin · Archives of Dermatological Research, 2022
- [Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/35620028/) Tretinoin · International Journal of Women's Dermatology, 2022

## Other combinations

- Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/sg/ingredients/retinol-and-niacinamide)
- Depends on the strength: [AHA blend glycolic and citric acids and niacinamide](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-niacinamide)
- Depends on the strength: [Niacinamide and citric acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-citric-acid)
- Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-niacinamide)
- Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-lactic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-mandelic-acid)
- Depends on the strength: [Niacinamide and salicylic acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-salicylic-acid)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/sg/ingredients/tretinoin-and-bio-placenta-peptides)
- Keep them apart: [Tretinoin and collagen peptide](https://lovi.care/skincare/sg/ingredients/tretinoin-and-collagen-peptide)
- Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/sg/ingredients/tretinoin-and-copper-peptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/sg/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/sg/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/sg/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/tretinoin-and-palmitoyl-tripeptide-1)
- Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/sg/ingredients/tretinoin-and-peptide-rich-plasma)
- Keep them apart: [Tretinoin and triple peptide blend](https://lovi.care/skincare/sg/ingredients/tretinoin-and-triple-peptide-blend)
- Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/sg/ingredients/niacinamide-and-gluconolactone)
- Depends on the strength: [Niacinamide and lactobionic acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-lactobionic-acid)
- Work well together: [Niacinamide and cholesterol](https://lovi.care/skincare/sg/ingredients/niacinamide-and-cholesterol)
- Work well together: [Niacinamide and lauric acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-lauric-acid)
- Work well together: [Niacinamide and linoleic acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-linoleic-acid)
- Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/sg/ingredients/niacinamide-and-tri-ceramide-complex)
- Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/sg/ingredients/adapalene-and-niacinamide)
- Depends on the strength: [Niacinamide and granactive retinoid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-granactive-retinoid)
- Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/sg/ingredients/niacinamide-and-hydroxypinacolone-retinoate)
- Depends on the strength: [Niacinamide and pro-retinol](https://lovi.care/skincare/sg/ingredients/niacinamide-and-pro-retinol)
- Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/sg/ingredients/niacinamide-and-retinal)
- Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/sg/ingredients/niacinamide-and-retinoid-blend)
- Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/sg/ingredients/niacinamide-and-vitamin-a)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/sg/ingredients/niacinamide-and-bio-placenta-peptides)
- Depends on the strength: [Niacinamide and collagen peptide](https://lovi.care/skincare/sg/ingredients/niacinamide-and-collagen-peptide)
- Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/sg/ingredients/niacinamide-and-copper-peptide)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/sg/ingredients/niacinamide-and-hexapeptide)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/sg/ingredients/niacinamide-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/sg/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/niacinamide-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/sg/ingredients/niacinamide-and-peptide-rich-plasma)
- Depends on the strength: [Niacinamide and triple peptide blend](https://lovi.care/skincare/sg/ingredients/niacinamide-and-triple-peptide-blend)
- Work well together: [Niacinamide and hyaluronic acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-hyaluronic-acid)
- Keep them apart: [AHA blend glycolic and citric acids and tretinoin](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-tretinoin)
- Keep them apart: [Tretinoin and citric acid](https://lovi.care/skincare/sg/ingredients/tretinoin-and-citric-acid)
- Keep them apart: [Glycolic acid and tretinoin](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-tretinoin)
- Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/sg/ingredients/tretinoin-and-lactic-acid)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/sg/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Niacinamide and bakuchiol](https://lovi.care/skincare/sg/ingredients/niacinamide-and-bakuchiol)
- Keep them apart: [Salicylic acid and tretinoin](https://lovi.care/skincare/sg/ingredients/salicylic-acid-and-tretinoin)
- Keep them apart: [Vitamin C and tretinoin](https://lovi.care/skincare/sg/ingredients/vitamin-c-and-tretinoin)
- Work well together: [Niacinamide and zinc](https://lovi.care/skincare/sg/ingredients/niacinamide-and-zinc)
- Work well together: [Niacinamide and zinc gluconate](https://lovi.care/skincare/sg/ingredients/niacinamide-and-zinc-gluconate)
- Work well together: [Niacinamide and zinc oxide](https://lovi.care/skincare/sg/ingredients/niacinamide-and-zinc-oxide)
- Work well together: [Niacinamide and zinc sulfate](https://lovi.care/skincare/sg/ingredients/niacinamide-and-zinc-sulfate)
- Work well together: [Benzoyl peroxide and niacinamide](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-niacinamide)
- Keep them apart: [Niacinamide and lipohydroxy acid](https://lovi.care/skincare/sg/ingredients/niacinamide-and-lipohydroxy-acid)
- Keep them apart: [Benzoyl peroxide and tretinoin](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-tretinoin)
- Work well together: [Ferulic acid and niacinamide](https://lovi.care/skincare/sg/ingredients/ferulic-acid-and-niacinamide)
- Work well together: [Green tea and niacinamide](https://lovi.care/skincare/sg/ingredients/green-tea-and-niacinamide)
- Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/sg/ingredients/niacinamide-and-vitamin-e)
- Keep them apart: [Niacinamide and isopropyl alcohol](https://lovi.care/skincare/sg/ingredients/niacinamide-and-isopropyl-alcohol)
- Work well together: [Niacinamide and ascorbyl glucoside](https://lovi.care/skincare/sg/ingredients/niacinamide-and-ascorbyl-glucoside)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/niacinamide-and-tretinoin
- United Kingdom: https://lovi.care/skincare/uk/ingredients/niacinamide-and-tretinoin
- Ireland: https://lovi.care/skincare/ie/ingredients/niacinamide-and-tretinoin
- Germany: https://lovi.care/skincare/de/ingredients/niacinamide-and-tretinoin
- France: https://lovi.care/skincare/fr/ingredients/niacinamide-and-tretinoin
- Italy: https://lovi.care/skincare/it/ingredients/niacinamide-and-tretinoin
- Netherlands: https://lovi.care/skincare/nl/ingredients/niacinamide-and-tretinoin
- Spain: https://lovi.care/skincare/es/ingredients/niacinamide-and-tretinoin
- Canada: https://lovi.care/skincare/ca/ingredients/niacinamide-and-tretinoin
- Australia: https://lovi.care/skincare/au/ingredients/niacinamide-and-tretinoin
- Singapore: https://lovi.care/skincare/sg/ingredients/niacinamide-and-tretinoin (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/niacinamide-and-tretinoin
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/niacinamide-and-tretinoin