# Azelaic acid and acetyl hexapeptide-3

Page: https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-acetyl-hexapeptide-3

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Keep them apart

Use them at different times of day by applying [azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) in the morning and [acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3) at night, because acids break down peptides. Mixing them makes the peptide ingredient less effective on your skin, so you will not see the firming results you want. You can fix this by using your acid in the morning and your peptide at night, or by waiting until the first product is fully absorbed before applying the next one.

- [All about azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid)
- [All about acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3)

### [Azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) products

- [The Ordinary Azelaic Acid Suspension 10%](https://lovi.care/skincare/sg/p/the-ordinary/azelaic-acid-suspension-10/for/acne-prone-skin) — High fit
- [Paula's Choice 10% Azelaic Acid Booster](https://lovi.care/skincare/sg/p/paula-s-choice/10-azelaic-acid-booster/for/acne-prone-skin) — High fit
- [Topicals Faded Serum](https://lovi.care/skincare/sg/p/topicals/faded-serum/for/oily-acne-prone-skin) — Superior fit
- [NATURIUM Azelaic Topical Acid 10%](https://lovi.care/skincare/sg/p/naturium/azelaic-topical-acid-10/for/acne-prone-skin) — Superior fit
- [Musely The Spot Cream](https://lovi.care/skincare/sg/p/musely/the-spot-cream/for/mature-skin) — High fit
- [Topicals Faded Brightening & Clearing Serum](https://lovi.care/skincare/sg/p/topicals/faded-brightening-and-clearing-serum/for/acne-prone-skin) — High fit
- [Bioderma Pigmentbio Sensitive Areas](https://lovi.care/skincare/sg/p/bioderma/pigmentbio-sensitive-areas/for/oily-acne-prone-skin) — High fit
- [Peach Slices Redness Relief Azelaic Acid Serum](https://lovi.care/skincare/sg/p/peach-slices/redness-relief-azelaic-acid-serum/for/sensitive-skin) — High fit
- [Finacea Gel](https://lovi.care/skincare/sg/p/finacea/gel/for/oily-acne-prone-skin) — High fit
- [NATURIUM Niacinamide Cleansing Gelée 3%](https://lovi.care/skincare/sg/p/naturium/niacinamide-cleansing-gelee-3/for/acne-prone-skin) — High fit
- [NATURIUM Azelaic Acid Emulsion 10%](https://lovi.care/skincare/sg/p/naturium/azelaic-acid-emulsion-10/for/acne-prone-skin) — High fit
- [StriVectin Daily Reveal Exfoliating Pads](https://lovi.care/skincare/sg/p/strivectin/daily-reveal-exfoliating-pads/for/oily-skin) — Average fit

### [Acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit
- [Medik8 Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit
- [La Mer The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [S$238.16 at Amazon](https://www.amazon.sg/dp/B076ZQ7YVB?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/sg/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/sg/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [S$38.42 at Amazon](https://www.amazon.sg/dp/B091MTKS35?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit
- [La Mer The Renewal Oil](https://lovi.care/skincare/sg/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [S$466.85 at Amazon](https://www.amazon.sg/dp/B0163GAMI4?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/sg/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/sg/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/sg/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [S$337.38 at Amazon](https://www.amazon.sg/dp/B00438A000?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use azelaic acid and acetyl hexapeptide-3 together?

Keep [azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) and [acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3) apart because low-pH acids like azelaic acid can break down peptides and reduce their activity. Use them in separate steps or routines, such as using one in the morning and the other at night.

### Which goes first, azelaic acid or acetyl hexapeptide-3?

Keep azelaic acid and acetyl hexapeptide-3 apart by using them in separate steps or routines, such as applying one in the morning and the other at night. Combining them directly is not recommended because the low pH of azelaic acid can reduce the activity of the peptide.

### Are azelaic acid and acetyl hexapeptide-3 good for sensitive skin?

Keep azelaic acid and acetyl hexapeptide-3 apart in your routine to avoid skin irritation. You should use them in separate steps or routines, such as separating them between morning and evening.

## Research on azelaic acid and acetyl hexapeptide-3

- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and hyaluronic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-hyaluronic-acid)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and aha blend glycolic and citric acids](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-aha-blend-glycolic-and-citric-acids)
- Keep them apart: [Azelaic acid and citric acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-citric-acid)
- Keep them apart: [Glycolic acid and azelaic acid](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-azelaic-acid)
- Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-lactic-acid)
- Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-mandelic-acid)
- Keep them apart: [Azelaic acid and salicylic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-salicylic-acid)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and bio-placenta peptides](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-bio-placenta-peptides)
- Keep them apart: [Azelaic acid and collagen peptide](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-collagen-peptide)
- Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-copper-peptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Azelaic acid and peptide-rich plasma](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-peptide-rich-plasma)
- Keep them apart: [Azelaic acid and triple peptide blend](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-triple-peptide-blend)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- United Kingdom: https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Ireland: https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Germany: https://lovi.care/skincare/de/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- France: https://lovi.care/skincare/fr/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Italy: https://lovi.care/skincare/it/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Netherlands: https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Spain: https://lovi.care/skincare/es/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Canada: https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Australia: https://lovi.care/skincare/au/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- Singapore: https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-acetyl-hexapeptide-3 (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-acetyl-hexapeptide-3
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/azelaic-acid-and-acetyl-hexapeptide-3