# Acetyl hexapeptide-3

Page: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Acetyl hexapeptide-3 softens the look of wrinkles, lessens skin roughness, and boosts skin hydration. It suits dry skin and oily skin best, and comes in [serums](https://lovi.care/skincare/sg/ingredients/serum), creams, eye creams, and masks. It fits well into a routine with [panthenol](https://lovi.care/skincare/sg/ingredients/panthenol), [green tea](https://lovi.care/skincare/sg/ingredients/green-tea), and [ceramide-building complex](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex), but you should keep it apart from [adapalene](https://lovi.care/skincare/sg/ingredients/adapalene), [glycolic acid](https://lovi.care/skincare/sg/ingredients/glycolic-acid), and [benzoyl peroxide](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide).

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/) [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

This page shows acetyl hexapeptide-3 products with a Lovi page. For every product, and a routine built for your skin, use the Lovi app.

### Popular acetyl hexapeptide-3 products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit
- [Medik8 Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit
- [La Mer The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [S$238.16 at Amazon](https://www.amazon.sg/dp/B076ZQ7YVB?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/sg/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/sg/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [S$38.42 at Amazon](https://www.amazon.sg/dp/B091MTKS35?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit

### Acetyl hexapeptide-3 [serums](https://lovi.care/skincare/sg/ingredients/serum)

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit
- [Medik8 Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/sg/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [S$38.42 at Amazon](https://www.amazon.sg/dp/B091MTKS35?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit
- [NATURIUM Multi-Peptide Advanced Serum](https://lovi.care/skincare/sg/p/naturium/multi-peptide-advanced-serum/for/mature-skin) — High fit
- [Perricone MD Cold Plasma Plus+](https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/mature-skin) — Average fit
- [La Mer The Regenerating Serum](https://lovi.care/skincare/sg/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — [S$40.09 at Amazon](https://www.amazon.sg/dp/B08DTTL17D?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Peach & Lily Copper Peptide Pro Firming Serum](https://lovi.care/skincare/sg/p/peach-and-lily/copper-peptide-pro-firming-serum/for/mature-skin) — High fit
- [Perricone MD Deep Crease Serum](https://lovi.care/skincare/sg/p/perricone-md/deep-crease-serum/for/dry-sensitive-skin) — High fit

## What reviewers say about popular acetyl hexapeptide-3 products

The highlight reviewers mention most for each popular acetyl hexapeptide-3 product on Lovi.

- The Ordinary Multi-Peptide + Copper Peptides 1% Serum Improves firmness ★4.5 · 3.2k+ reviews Lightweight absorption Smooths texture “Nature's botox” [What people say about Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin)
- The Ordinary Multi-Peptide + HA Serum Deeply hydrates ★4.4 · 2.5k+ reviews Great value Smooths texture “Surprisingly hydrated my skin very well in the dry mountain air.” [What people say about Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin)
- Medik8 Liquid Peptides Deeply hydrating ★4.6 · 200+ reviews Elegant, lightweight texture Visibly plumps and smooths “Restores moisture” [What people say about Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin)
- La Mer The Treatment Lotion Deep Hydration ★4.6 · 2.5k+ reviews Exorbitant Price Luxurious Texture “skin drinks it up” [What people say about The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/mature-skin)
- Rhode Peptide Glazing Fluid Lightweight texture ★4.6 · 96.0k+ reviews Great makeup base Hydrating feel “watery gel” [What people say about Peptide Glazing Fluid](https://lovi.care/skincare/sg/p/rhode/peptide-glazing-fluid/for/mature-skin)
- The Ordinary Argireline Solution 10% Softens dynamic lines ★4.3 · 2.5k+ reviews Affordable price point Lightweight watery texture “Softened my deep forehead lines” [What people say about Argireline Solution 10%](https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/mature-skin)

### Acetyl hexapeptide-3 creams

- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/sg/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit
- [La Mer The Renewal Oil](https://lovi.care/skincare/sg/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [S$466.85 at Amazon](https://www.amazon.sg/dp/B0163GAMI4?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/sg/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [Estée Lauder Perfectionist Pro](https://lovi.care/skincare/sg/p/estee-lauder/perfectionist-pro/for/mature-skin) — Average fit
- [Clinique Smart Clinical Repair Lifting Face + Neck Cream](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-lifting-face-neck-cream/for/mature-skin) — Superior fit
- [MiamiMD Age Defying Lift & Firm Cream](https://lovi.care/skincare/sg/p/miamimd/age-defying-lift-and-firm-cream/for/dry-skin) — High fit
- [Some By Mi Beta Panthenol Repair Cream](https://lovi.care/skincare/sg/p/some-by-mi/beta-panthenol-repair-cream/for/oily-acne-prone-skin) — High fit — [S$31.71 at Amazon](https://www.amazon.sg/dp/B0BYS91VQD?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Le Mieux Bio Cell Rejuvenating Cream](https://lovi.care/skincare/sg/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-sensitive-skin) — High fit
- [Biossance Squalane + Ectoin Overnight Rescue](https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin) — High fit
- [MAC Mineralize Timecheck Lotion](https://lovi.care/skincare/sg/p/mac/mineralize-timecheck-lotion/for/dry-skin) — High fit
- [Estée Lauder Futurist Peptide-Power Serum Primer](https://lovi.care/skincare/sg/p/estee-lauder/futurist-peptide-power-serum-primer/for/mature-skin) — Superior fit
- [Estée Lauder Re-Nutriv Ultimate Diamond Transformative Energy Creme](https://lovi.care/skincare/sg/p/estee-lauder/re-nutriv-ultimate-diamond-transformative-energy-creme/for/dry-sensitive-skin) — High fit

### Acetyl hexapeptide-3 eye creams

- [La Mer The Eye Concentrate](https://lovi.care/skincare/sg/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [S$337.38 at Amazon](https://www.amazon.sg/dp/B00438A000?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [La Mer The Lifting Eye Serum](https://lovi.care/skincare/sg/p/la-mer/the-lifting-eye-serum/for/mature-skin) — High fit
- [Heimish Marine Care Eye Cream](https://lovi.care/skincare/sg/p/heimish/marine-care-eye-cream/for/dry-skin) — Warning fit
- [Clinique Pep-Start Eye Cream](https://lovi.care/skincare/sg/p/clinique/pep-start-eye-cream/for/mature-skin) — High fit
- [Medicube Deep Reviving Peptide Eye Cream](https://lovi.care/skincare/sg/p/medicube/deep-reviving-peptide-eye-cream/for/dark-spots) — High fit
- [Estée Lauder Revitalizing Supreme+ Youth Power Eye Balm](https://lovi.care/skincare/sg/p/estee-lauder/revitalizing-supreme-youth-power-eye-balm/for/dry-skin) — High fit
- [Mediheal N.M.F Aquaring Gel Eyefill Patch](https://lovi.care/skincare/sg/p/mediheal/n-m-f-aquaring-gel-eyefill-patch/for/dry-sensitive-skin) — Superior fit

### Acetyl hexapeptide-3 masks

- [La Mer The Lifting and Firming Mask](https://lovi.care/skincare/sg/p/la-mer/the-lifting-and-firming-mask/for/mature-skin) — High fit
- [La Mer The Intensive Revitalizing Mask](https://lovi.care/skincare/sg/p/la-mer/the-intensive-revitalizing-mask/for/mature-skin) — High fit — [S$349.83 at Amazon](https://www.amazon.sg/dp/B00MZT0MDO?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Aceology Lifting Treatment Mask](https://lovi.care/skincare/sg/p/aceology/lifting-treatment-mask/for/sensitive-skin) — Average fit
- [Origins Plantscription Powerful Lifting Overnight Mask](https://lovi.care/skincare/sg/p/origins/plantscription-powerful-lifting-overnight-mask/for/mature-skin) — Superior fit
- [Pixi by Petra PLUMP Collagen Boost](https://lovi.care/skincare/sg/p/pixi-by-petra/plump-collagen-boost/for/dry-skin) — High fit — [S$19.83 at Amazon](https://www.amazon.sg/dp/B09YHZG8NC?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Estée Lauder Re-Nutriv Ultimate Diamond Revitalizing Mask Noir](https://lovi.care/skincare/sg/p/estee-lauder/re-nutriv-ultimate-diamond-revitalizing-mask-noir/for/mature-skin) — Average fit

### Acetyl hexapeptide-3 for dry skin

- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — [S$40.09 at Amazon](https://www.amazon.sg/dp/B08DTTL17D?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit
- [La Mer The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/dry-skin) — Superior fit — [S$238.16 at Amazon](https://www.amazon.sg/dp/B076ZQ7YVB?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/sg/p/estee-lauder/micro-essence-treatment-lotion/for/dry-skin) — High fit
- [Estée Lauder Revitalizing Supreme+ Youth Power Eye Balm](https://lovi.care/skincare/sg/p/estee-lauder/revitalizing-supreme-youth-power-eye-balm/for/dry-skin) — High fit
- [Mediheal N.M.F Aquaring Gel Eyefill Patch](https://lovi.care/skincare/sg/p/mediheal/n-m-f-aquaring-gel-eyefill-patch/for/dry-skin) — High fit
- [Pixi by Petra PLUMP Collagen Boost](https://lovi.care/skincare/sg/p/pixi-by-petra/plump-collagen-boost/for/dry-skin) — High fit — [S$19.83 at Amazon](https://www.amazon.sg/dp/B09YHZG8NC?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/dry-skin) — High fit
- [Clinique Smart Clinical Repair Lifting Face + Neck Cream](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-lifting-face-neck-cream/for/dry-skin) — High fit
- [Sulwhasoo The Ultimate S Cream](https://lovi.care/skincare/sg/p/sulwhasoo/the-ultimate-s-cream/for/dry-skin) — High fit — [S$529.87 at YesStyle](https://www.yesstyle.com/en/sulwhasoo-the-ultimate-s-cream-60ml/info.html/pid.1125714968?curr=SGD&rco=SG)
- [Some By Mi Beta Panthenol Repair Cream](https://lovi.care/skincare/sg/p/some-by-mi/beta-panthenol-repair-cream/for/dry-skin) — High fit — [S$31.71 at Amazon](https://www.amazon.sg/dp/B0BYS91VQD?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Le Mieux Bio Cell Rejuvenating Cream](https://lovi.care/skincare/sg/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin) — High fit

### Acetyl hexapeptide-3 for oily skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/sg/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-skin) — Superior fit
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/sg/p/estee-lauder/micro-essence-treatment-lotion/for/oily-skin) — High fit
- [Some By Mi Beta Panthenol Repair Cream](https://lovi.care/skincare/sg/p/some-by-mi/beta-panthenol-repair-cream/for/oily-skin) — High fit — [S$31.71 at Amazon](https://www.amazon.sg/dp/B0BYS91VQD?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/oily-skin) — High fit — [S$238.16 at Amazon](https://www.amazon.sg/dp/B076ZQ7YVB?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Mediheal N.M.F Aquaring Gel Eyefill Patch](https://lovi.care/skincare/sg/p/mediheal/n-m-f-aquaring-gel-eyefill-patch/for/oily-skin) — Average fit
- [Medicube Deep Reviving Peptide Eye Cream](https://lovi.care/skincare/sg/p/medicube/deep-reviving-peptide-eye-cream/for/oily-skin) — Average fit
- [Origins Original Skin Renewal Serum](https://lovi.care/skincare/sg/p/origins/original-skin-renewal-serum/for/oily-skin) — Average fit
- [La Mer The Regenerating Serum](https://lovi.care/skincare/sg/p/la-mer/the-regenerating-serum/for/oily-skin) — Average fit
- [Estée Lauder Futurist Peptide-Power Serum Primer](https://lovi.care/skincare/sg/p/estee-lauder/futurist-peptide-power-serum-primer/for/oily-skin) — Average fit
- [Image Skincare the MAX™ Stem Cell Serum](https://lovi.care/skincare/sg/p/image-skincare/the-maxtm-stem-cell-serum/for/oily-skin) — Average fit
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/oily-skin) — Average fit
- [Biossance Squalane + Ectoin Overnight Rescue](https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/oily-skin) — Average fit

### Acetyl hexapeptide-3 for combination skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/sg/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit
- [La Mer The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/combination-skin) — High fit — [S$238.16 at Amazon](https://www.amazon.sg/dp/B076ZQ7YVB?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/sg/p/estee-lauder/micro-essence-treatment-lotion/for/combination-skin) — High fit
- [Some By Mi Beta Panthenol Repair Cream](https://lovi.care/skincare/sg/p/some-by-mi/beta-panthenol-repair-cream/for/combination-skin) — High fit — [S$31.71 at Amazon](https://www.amazon.sg/dp/B0BYS91VQD?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Mediheal N.M.F Aquaring Gel Eyefill Patch](https://lovi.care/skincare/sg/p/mediheal/n-m-f-aquaring-gel-eyefill-patch/for/combination-skin) — High fit
- [Medicube Deep Reviving Peptide Eye Cream](https://lovi.care/skincare/sg/p/medicube/deep-reviving-peptide-eye-cream/for/combination-skin) — High fit
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/combination-skin) — High fit
- [Estée Lauder Futurist Peptide-Power Serum Primer](https://lovi.care/skincare/sg/p/estee-lauder/futurist-peptide-power-serum-primer/for/combination-skin) — High fit
- [PCA SKIN ExLinea Pro Peptide Serum](https://lovi.care/skincare/sg/p/pca-skin/exlinea-pro-peptide-serum/for/combination-skin) — High fit
- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin) — High fit
- [Biossance Squalane + Ectoin Overnight Rescue](https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/combination-skin) — Average fit
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/sg/p/the-inkey-list/collagen-peptide-serum/for/combination-skin) — Average fit

## All acetyl hexapeptide-3 products

- The Ordinary · Serum or Treatment: [Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin)
- The Ordinary · Serum or Treatment: [Multi-Peptide + HA Serum](https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin)
- Medik8 · Serum or Treatment: [Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin)
- La Mer · Hydrating Toner: [The Treatment Lotion](https://lovi.care/skincare/sg/p/la-mer/the-treatment-lotion/for/mature-skin)
- Rhode · Moisturizing serum: [Peptide Glazing Fluid](https://lovi.care/skincare/sg/p/rhode/peptide-glazing-fluid/for/mature-skin)
- The Ordinary · Serum or Treatment: [Argireline Solution 10%](https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/mature-skin)
- Good Molecules · Serum or Treatment: [Super Peptide Serum](https://lovi.care/skincare/sg/p/good-molecules/super-peptide-serum/for/mature-skin)
- Clinique · Serum or Treatment: [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin)
- La Mer · Moisturizing serum: [The Renewal Oil](https://lovi.care/skincare/sg/p/la-mer/the-renewal-oil/for/mature-skin)
- Estée Lauder · Hydrating Toner: [Micro Essence Treatment Lotion](https://lovi.care/skincare/sg/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin)
- The INKEY List · Moisturizing serum: [Collagen Peptide Serum](https://lovi.care/skincare/sg/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin)
- La Mer · Eye Care: [The Eye Concentrate](https://lovi.care/skincare/sg/p/la-mer/the-eye-concentrate/for/mature-skin)
- NATURIUM · Serum or Treatment: [Multi-Peptide Advanced Serum](https://lovi.care/skincare/sg/p/naturium/multi-peptide-advanced-serum/for/mature-skin)
- Perricone MD · Serum or Treatment: [Cold Plasma Plus+](https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/mature-skin)
- La Mer · Serum or Treatment: [The Regenerating Serum](https://lovi.care/skincare/sg/p/la-mer/the-regenerating-serum/for/mature-skin)
- La Mer · Nourishing Mask: [The Lifting and Firming Mask](https://lovi.care/skincare/sg/p/la-mer/the-lifting-and-firming-mask/for/mature-skin)
- Estée Lauder · Moisturizing serum: [Perfectionist Pro](https://lovi.care/skincare/sg/p/estee-lauder/perfectionist-pro/for/mature-skin)
- ma:nyo · Serum or Treatment: [Bifida Biome Complex Ampoule](https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin)
- Peach & Lily · Serum or Treatment: [Copper Peptide Pro Firming Serum](https://lovi.care/skincare/sg/p/peach-and-lily/copper-peptide-pro-firming-serum/for/mature-skin)
- La Mer · Nourishing Mask: [The Intensive Revitalizing Mask](https://lovi.care/skincare/sg/p/la-mer/the-intensive-revitalizing-mask/for/mature-skin)
- Clinique · Moisturizing serum: [Smart Clinical Repair Lifting Face + Neck Cream](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-lifting-face-neck-cream/for/mature-skin)
- MiamiMD · Moisturizing serum: [Age Defying Lift & Firm Cream](https://lovi.care/skincare/sg/p/miamimd/age-defying-lift-and-firm-cream/for/dry-skin)
- Perricone MD · Serum or Treatment: [Deep Crease Serum](https://lovi.care/skincare/sg/p/perricone-md/deep-crease-serum/for/dry-sensitive-skin)
- La Mer · Eye Care: [The Lifting Eye Serum](https://lovi.care/skincare/sg/p/la-mer/the-lifting-eye-serum/for/mature-skin)

[See all 49 acetyl hexapeptide-3 products](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3/all)

## What to combine acetyl hexapeptide-3 with

Ingredient Together How to use them

[Panthenol](https://lovi.care/skincare/sg/ingredients/panthenol) Works well Use them together in the same routine, applying [panthenol](https://lovi.care/skincare/sg/ingredients/panthenol) first and acetyl hexapeptide-3 second, for better anti-aging and skin repair. [Acetyl hexapeptide-3 and panthenol](https://lovi.care/skincare/sg/ingredients/panthenol-and-acetyl-hexapeptide-3) [Green tea](https://lovi.care/skincare/sg/ingredients/green-tea) Works well Use them together, applying the [green tea](https://lovi.care/skincare/sg/ingredients/green-tea) first and the peptide second, for better protection against everyday skin aging. [Acetyl hexapeptide-3 and green tea](https://lovi.care/skincare/sg/ingredients/green-tea-and-acetyl-hexapeptide-3) [Ceramide-building complex](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex) Works well Use them together in the same routine, applying the peptide [serum](https://lovi.care/skincare/sg/ingredients/serum) first and following with the ceramide cream. [Acetyl hexapeptide-3 and ceramide-building complex](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) [Glycerin](https://lovi.care/skincare/sg/ingredients/glycerin) Works well Use them together by applying the [glycerin](https://lovi.care/skincare/sg/ingredients/glycerin) serum before the peptide product, because hydration helps the peptide work better. [Acetyl hexapeptide-3 and glycerin](https://lovi.care/skincare/sg/ingredients/glycerin-and-acetyl-hexapeptide-3) [Coenzyme Q10](https://lovi.care/skincare/sg/ingredients/coenzyme-q10) Works well Use them together in the same routine, applying the [coenzyme Q10](https://lovi.care/skincare/sg/ingredients/coenzyme-q10) first and the peptide second for the best anti-aging results. [Acetyl hexapeptide-3 and coenzyme q10](https://lovi.care/skincare/sg/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) [Vitamin E](https://lovi.care/skincare/sg/ingredients/vitamin-e) Works well Use them together in the same routine, applying the peptide first and the [vitamin E](https://lovi.care/skincare/sg/ingredients/vitamin-e) right after, because vitamin E keeps peptides fresh and strong. [Acetyl hexapeptide-3 and vitamin E](https://lovi.care/skincare/sg/ingredients/vitamin-e-and-acetyl-hexapeptide-3) [Bakuchiol](https://lovi.care/skincare/sg/ingredients/bakuchiol) Works well Use them together in the same routine, applying [bakuchiol](https://lovi.care/skincare/sg/ingredients/bakuchiol) first and acetyl hexapeptide-3 right after for smoother, firmer skin. [Acetyl hexapeptide-3 and bakuchiol](https://lovi.care/skincare/sg/ingredients/bakuchiol-and-acetyl-hexapeptide-3) [Silk amino acids](https://lovi.care/skincare/sg/ingredients/silk-amino-acids) Works well Use them together, applying [silk amino acids](https://lovi.care/skincare/sg/ingredients/silk-amino-acids) first and acetyl hexapeptide-3 right after, to boost hydration and repair. [Acetyl hexapeptide-3 and silk amino acids](https://lovi.care/skincare/sg/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3) [Arginine](https://lovi.care/skincare/sg/ingredients/arginine) Works well Use them together, applying the amino acid first and the peptide right after, because they help each other keep your skin hydrated and firm. [Acetyl hexapeptide-3 and arginine](https://lovi.care/skincare/sg/ingredients/arginine-and-acetyl-hexapeptide-3) [Liposome](https://lovi.care/skincare/sg/ingredients/liposome) Works well Use them together by applying the [liposome](https://lovi.care/skincare/sg/ingredients/liposome) product first, because the liposome protects the peptide from breaking down. [Acetyl hexapeptide-3 and liposome](https://lovi.care/skincare/sg/ingredients/liposome-and-acetyl-hexapeptide-3) [Taurine](https://lovi.care/skincare/sg/ingredients/taurine) Works well Use them together in the morning and evening, because [taurine](https://lovi.care/skincare/sg/ingredients/taurine) helps peptides work better for your skin. [Acetyl hexapeptide-3 and taurine](https://lovi.care/skincare/sg/ingredients/taurine-and-acetyl-hexapeptide-3) [Hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) Works well Apply the [hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) first and the peptide product right after, because they work wonderfully when used in the same routine. [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) [Microcapsule](https://lovi.care/skincare/sg/ingredients/microcapsule) Works well Use them together in the same routine, applying the [microcapsule](https://lovi.care/skincare/sg/ingredients/microcapsule) first to help the peptide absorb better and last longer. [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-microcapsule) [Cholesterol](https://lovi.care/skincare/sg/ingredients/cholesterol) Works well Use them together in the same routine, applying the peptide first and the [cholesterol](https://lovi.care/skincare/sg/ingredients/cholesterol) right after. [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-cholesterol) [Phytosphingosine](https://lovi.care/skincare/sg/ingredients/phytosphingosine) Works well Use them together in the same routine, applying the peptide product first followed by the ceramide cream, for better barrier support. [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) [Betaine](https://lovi.care/skincare/sg/ingredients/betaine) Works well Use them together by applying the hydrating serum first, because moisture helps the anti-wrinkle peptide work better. [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-betaine) [Phytosterol](https://lovi.care/skincare/sg/ingredients/phytosterol) Works well Use them together in the same routine, applying the peptide first and the plant lipid second for better moisture. [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosterol) [Beta-sitosterol](https://lovi.care/skincare/sg/ingredients/beta-sitosterol) Works well Use them together in the same routine, applying the plant sterol first and the peptide right after, because lipids help peptides absorb better. [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) [Squalene](https://lovi.care/skincare/sg/ingredients/squalene) Works well Use them together in the same routine, applying the [squalene](https://lovi.care/skincare/sg/ingredients/squalene) after the peptide. [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-squalene) [Tri-ceramide complex](https://lovi.care/skincare/sg/ingredients/tri-ceramide-complex) Works well Use them together in the same routine, applying the peptide serum first followed by the ceramide cream, because lipids help peptides absorb better. [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) [GABA](https://lovi.care/skincare/sg/ingredients/gaba) Works well Use them together, applying the peptide first and [GABA](https://lovi.care/skincare/sg/ingredients/gaba) second, for better skin firmness and hydration. [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-gaba) [Theanine](https://lovi.care/skincare/sg/ingredients/theanine) Works well Use acetyl hexapeptide-3 and [theanine](https://lovi.care/skincare/sg/ingredients/theanine) together in the same routine, applying them at the same time to help your skin stay hydrated and firm. [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-theanine) [Vitamin C](https://lovi.care/skincare/sg/ingredients/vitamin-c) Depends Apply [vitamin C](https://lovi.care/skincare/sg/ingredients/vitamin-c) in the morning and acetyl hexapeptide-3 at night, because combining them in the same routine makes them less effective. [Acetyl hexapeptide-3 and vitamin C](https://lovi.care/skincare/sg/ingredients/vitamin-c-and-acetyl-hexapeptide-3) [Retinol](https://lovi.care/skincare/sg/ingredients/retinol) Depends Use them at different times of day with [retinol](https://lovi.care/skincare/sg/ingredients/retinol) at night and peptides in the morning, because combining strong retinoids and peptides can cause irritation. [Acetyl hexapeptide-3 and retinol](https://lovi.care/skincare/sg/ingredients/retinol-and-acetyl-hexapeptide-3) [Niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide) Depends Use them together in the same routine, because [niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide) helps strengthen your skin while peptides work on firmness. [Acetyl hexapeptide-3 and niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide-and-acetyl-hexapeptide-3) [Adapalene](https://lovi.care/skincare/sg/ingredients/adapalene) Keep apart Use them at different times of day by applying acetyl hexapeptide-3 in the morning and [adapalene](https://lovi.care/skincare/sg/ingredients/adapalene) at night, because strong retinoids should not be mixed with peptides in the same routine. [Acetyl hexapeptide-3 and adapalene](https://lovi.care/skincare/sg/ingredients/adapalene-and-acetyl-hexapeptide-3) [Glycolic acid](https://lovi.care/skincare/sg/ingredients/glycolic-acid) Keep apart Use them at different times of day with [glycolic acid](https://lovi.care/skincare/sg/ingredients/glycolic-acid) in the morning and acetyl hexapeptide-3 at night because acid ruins peptide strength. [Acetyl hexapeptide-3 and glycolic acid](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) [Benzoyl peroxide](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide) Keep apart Use them at different times of day, applying the peptide cream in the morning and [benzoyl peroxide](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide) at night, because they clash and cancel each other out. [Acetyl hexapeptide-3 and benzoyl peroxide](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) [Azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) Keep apart Use them at different times of day by applying [azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) in the morning and acetyl hexapeptide-3 at night, because acids break down peptides. [Acetyl hexapeptide-3 and azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) [AHA blend glycolic and citric acids](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids) Keep apart Apply [aha blend glycolic and citric acids](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids) in the morning and acetyl hexapeptide-3 at night because acids break down peptides. [Acetyl hexapeptide-3 and aha blend glycolic and citric acids](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) [Salicylic acid](https://lovi.care/skincare/sg/ingredients/salicylic-acid) Keep apart Use them at different times of day, applying [salicylic acid](https://lovi.care/skincare/sg/ingredients/salicylic-acid) first and peptides later, because the acid breaks down the peptides. [Acetyl hexapeptide-3 and salicylic acid](https://lovi.care/skincare/sg/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) [Tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) Keep apart Use them at different times of day by applying acetyl hexapeptide-3 in the morning and [tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin) at night to prevent irritation. [Acetyl hexapeptide-3 and tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin-and-acetyl-hexapeptide-3) [Vitamin A](https://lovi.care/skincare/sg/ingredients/vitamin-a) Keep apart Use them at different times of day, applying the peptide product in the morning and the [vitamin A](https://lovi.care/skincare/sg/ingredients/vitamin-a) at night, to avoid extra skin irritation. [Acetyl hexapeptide-3 and vitamin A](https://lovi.care/skincare/sg/ingredients/vitamin-a-and-acetyl-hexapeptide-3) [Pro-retinol](https://lovi.care/skincare/sg/ingredients/pro-retinol) Keep apart Use them at different times of day with proretinol at night and acetyl hexapeptide-three in the morning to prevent extra skin irritation. [Acetyl hexapeptide-3 and pro-retinol](https://lovi.care/skincare/sg/ingredients/pro-retinol-and-acetyl-hexapeptide-3) [Retinal](https://lovi.care/skincare/sg/ingredients/retinal) Keep apart Use them at different times of day, applying [retinal](https://lovi.care/skincare/sg/ingredients/retinal) at night and acetyl hexapeptide-3 in the morning to avoid skin irritation. [Acetyl hexapeptide-3 and retinal](https://lovi.care/skincare/sg/ingredients/retinal-and-acetyl-hexapeptide-3) [Copper](https://lovi.care/skincare/sg/ingredients/copper) Keep apart Use them on alternate nights, applying [copper peptides](https://lovi.care/skincare/sg/ingredients/copper-peptide) on even days and acetyl hexapeptide-3 on odd days, to get the best results. [Acetyl hexapeptide-3 and copper](https://lovi.care/skincare/sg/ingredients/copper-and-acetyl-hexapeptide-3) [Magnesium](https://lovi.care/skincare/sg/ingredients/magnesium) Keep apart Use them at different times of day, applying the peptide first and the [magnesium](https://lovi.care/skincare/sg/ingredients/magnesium) later, because mixing them makes the peptide less effective. [Acetyl hexapeptide-3 and magnesium](https://lovi.care/skincare/sg/ingredients/magnesium-and-acetyl-hexapeptide-3) [Lactic acid](https://lovi.care/skincare/sg/ingredients/lactic-acid) Keep apart Use them at different times of day, applying [lactic acid](https://lovi.care/skincare/sg/ingredients/lactic-acid) in the morning and acetyl hexapeptide-3 at night, to prevent the acid from breaking down the peptide. [Acetyl hexapeptide-3 and lactic acid](https://lovi.care/skincare/sg/ingredients/lactic-acid-and-acetyl-hexapeptide-3) [Mandelic acid](https://lovi.care/skincare/sg/ingredients/mandelic-acid) Keep apart Use them at different times of day by applying your acid first and your peptide later, because acids break down peptides. [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) [Retinoid blend](https://lovi.care/skincare/sg/ingredients/retinoid-blend) Keep apart Use them at different times of day by applying the peptide serum in the morning and the retinoid at night to prevent skin irritation. [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) [Superoxide dismutase](https://lovi.care/skincare/sg/ingredients/superoxide-dismutase) Keep apart Use them at different times of day, applying the peptide first and the enzyme later, because they cancel each other out. [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) [Polyvinyl alcohol](https://lovi.care/skincare/sg/ingredients/polyvinyl-alcohol) Keep apart Use them at different times of day, applying the peptide first and the alcohol product later. [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) [Zinc](https://lovi.care/skincare/sg/ingredients/zinc) Keep apart Use [zinc](https://lovi.care/skincare/sg/ingredients/zinc) and acetyl hexapeptide-3 at different times of day, applying zinc in the morning and the peptide at night, because they clash and cancel each other out. [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc) [Zinc sulfate](https://lovi.care/skincare/sg/ingredients/zinc-sulfate) Keep apart Use them at different times of day, applying the peptide first, because they cancel each other out. [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) [Bleach](https://lovi.care/skincare/sg/ingredients/bleach) Keep apart Use them at different times of day, applying the peptide first and the [bleach](https://lovi.care/skincare/sg/ingredients/bleach) later, because bleach ruins the peptide. [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-bleach) [Granactive retinoid](https://lovi.care/skincare/sg/ingredients/granactive-retinoid) Keep apart Use them at different times of day by applying your peptide product in the morning and your retinoid at night. [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid) [Hydroxypinacolone retinoate](https://lovi.care/skincare/sg/ingredients/hydroxypinacolone-retinoate) Keep apart Use them at different times of day by applying the peptide product in the morning and the retinoid at night to avoid skin irritation. [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) [Potassium hydroxide](https://lovi.care/skincare/sg/ingredients/potassium-hydroxide) Keep apart Use them at different times of day, applying acetyl hexapeptide-3 first and [potassium hydroxide](https://lovi.care/skincare/sg/ingredients/potassium-hydroxide) later, because they clash in acidity. [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) [Citric acid](https://lovi.care/skincare/sg/ingredients/citric-acid) Keep apart Use them at different times of day, applying the acid first and the peptide second, because acid breaks down the peptide. [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-citric-acid) [Isopropyl alcohol](https://lovi.care/skincare/sg/ingredients/isopropyl-alcohol) Keep apart Apply the peptide product first, wait ten minutes, and then use the alcohol product later, because harsh solvents can ruin anti-aging results. [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) [Behenyl alcohol](https://lovi.care/skincare/sg/ingredients/behenyl-alcohol) Keep apart Apply them at different times of day, using the peptide first and the alcohol later, because heavy alcohols can break down the peptide structure. [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) [Protease](https://lovi.care/skincare/sg/ingredients/protease) Keep apart Use them at different times of day, applying acetyl hexapeptide-3 in the morning and [protease](https://lovi.care/skincare/sg/ingredients/protease) at night, because they clash when mixed. [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-protease) [Baking soda](https://lovi.care/skincare/sg/ingredients/baking-soda) Keep apart Use them at different times of day, applying the peptide first and the [baking soda](https://lovi.care/skincare/sg/ingredients/baking-soda) later, because they clash in chemical balance. [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-baking-soda)

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

## Questions and answers

### What does acetyl hexapeptide-3 do for the skin?

Acetyl hexapeptide-3 helps smooth wrinkles and decrease skin roughness when applied twice daily. Lovi rates the fit for anti-aging care as Superior.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### How do you use acetyl hexapeptide-3?

You can use acetyl hexapeptide-3 twice daily to help reduce wrinkles and skin roughness. When combining it with active ingredients, use compatible ones like [panthenol](https://lovi.care/skincare/sg/ingredients/panthenol) or [hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) in your routine, while keeping acids and retinoids separate at different times of day.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Should you use acetyl hexapeptide-3 in the morning or at night?

You may use acetyl hexapeptide-3 twice daily, as consistent application helps produce significant anti-wrinkle effects and decreases skin roughness.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can you use acetyl hexapeptide-3 every day?

Yes, you can use acetyl hexapeptide-3 every day by applying it twice daily for four weeks to help reduce wrinkle depth and decrease skin roughness. Lovi assigns this ingredient an Average fit for daily anti-aging routines.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Does acetyl hexapeptide-3 cause purging or irritation?

Acetyl hexapeptide-3 is unlikely to cause skin purging because it does not speed up cell turnover, and it is generally well tolerated without causing significant irritation when used alone. Lovi finds the overall fit for this ingredient to be High.

### Which skin types is acetyl hexapeptide-3 best for?

Acetyl hexapeptide-3 is suitable for all skin types, with top-rated product fits varying depending on your specific skin concerns. For dry skin, Lovi rates myąyo Bifida Biome [Complex](https://lovi.care/skincare/sg/ingredients/complex) Ampoule, The Ordinary Multi-Peptide + HA [Serum](https://lovi.care/skincare/sg/ingredients/serum), and La Mer The Treatment Lotion as Superior fits. For mature skin, Lovi lists Clinique Smart Clinical Repair Lifting Face + Neck Cream, La Mer The Treatment Lotion, and Origins Plantscription Powerful Lifting Overnight Mask as Superior fits.

### Can you use acetyl hexapeptide-3 with panthenol?

Yes, you can use acetyl hexapeptide-3 with panthenol together in the same routine, applying panthenol first and acetyl hexapeptide-3 second, for better anti-aging and skin repair.

### Can you use acetyl hexapeptide-3 with adapalene?

You should keep acetyl hexapeptide-3 and [adapalene](https://lovi.care/skincare/sg/ingredients/adapalene) apart by using them at different times of day, applying acetyl hexapeptide-3 in the morning and adapalene at night, because strong retinoids should not be mixed with peptides in the same routine.

## Research on acetyl hexapeptide-3

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Combining acetyl hexapeptide-3

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## Brands with acetyl hexapeptide-3

- Canadian skincare: [The Ordinary](https://lovi.care/skincare/sg/brands/the-ordinary)
- Korean skincare: [ma:nyo](https://lovi.care/skincare/sg/brands/ma-nyo)
- American skincare: [La Mer](https://lovi.care/skincare/sg/brands/la-mer)
- American skincare: [Clinique](https://lovi.care/skincare/sg/brands/clinique)
- British skincare: [Medik8](https://lovi.care/skincare/sg/brands/medik8)
- Korean skincare: [Some By Mi](https://lovi.care/skincare/sg/brands/some-by-mi)
- Korean skincare: [FRANKLY](https://lovi.care/skincare/sg/brands/frankly)
- American skincare: [Estée Lauder](https://lovi.care/skincare/sg/brands/estee-lauder)
- American skincare: [NATURIUM](https://lovi.care/skincare/sg/brands/naturium)
- American skincare: [Rhode](https://lovi.care/skincare/sg/brands/rhode)

## Related ingredients

- [Adapalene](https://lovi.care/skincare/sg/ingredients/adapalene)
- [Glycolic acid](https://lovi.care/skincare/sg/ingredients/glycolic-acid)
- [Benzoyl peroxide](https://lovi.care/skincare/sg/ingredients/benzoyl-peroxide)
- [Vitamin C](https://lovi.care/skincare/sg/ingredients/vitamin-c)
- [Retinol](https://lovi.care/skincare/sg/ingredients/retinol)
- [Azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid)
- [Panthenol](https://lovi.care/skincare/sg/ingredients/panthenol)
- [AHA blend glycolic and citric acids](https://lovi.care/skincare/sg/ingredients/aha-blend-glycolic-and-citric-acids)
- [Green tea](https://lovi.care/skincare/sg/ingredients/green-tea)
- [Niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide)
- [Salicylic acid](https://lovi.care/skincare/sg/ingredients/salicylic-acid)
- [Ceramide-building complex](https://lovi.care/skincare/sg/ingredients/ceramide-building-complex)
- [Tretinoin](https://lovi.care/skincare/sg/ingredients/tretinoin)
- [Glycerin](https://lovi.care/skincare/sg/ingredients/glycerin)
- [Coenzyme Q10](https://lovi.care/skincare/sg/ingredients/coenzyme-q10)
- [Vitamin E](https://lovi.care/skincare/sg/ingredients/vitamin-e)
- [Bakuchiol](https://lovi.care/skincare/sg/ingredients/bakuchiol)
- [Silk amino acids](https://lovi.care/skincare/sg/ingredients/silk-amino-acids)
- [Vitamin A](https://lovi.care/skincare/sg/ingredients/vitamin-a)
- [Arginine](https://lovi.care/skincare/sg/ingredients/arginine)
- [Liposome](https://lovi.care/skincare/sg/ingredients/liposome)
- [Pro-retinol](https://lovi.care/skincare/sg/ingredients/pro-retinol)
- [Retinal](https://lovi.care/skincare/sg/ingredients/retinal)
- [Copper](https://lovi.care/skincare/sg/ingredients/copper)
- [Magnesium](https://lovi.care/skincare/sg/ingredients/magnesium)
- [Lactic acid](https://lovi.care/skincare/sg/ingredients/lactic-acid)
- [Taurine](https://lovi.care/skincare/sg/ingredients/taurine)
- [Mandelic acid](https://lovi.care/skincare/sg/ingredients/mandelic-acid)
- [Retinoid blend](https://lovi.care/skincare/sg/ingredients/retinoid-blend)
- [Superoxide dismutase](https://lovi.care/skincare/sg/ingredients/superoxide-dismutase)
- [Hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid)
- [Polyvinyl alcohol](https://lovi.care/skincare/sg/ingredients/polyvinyl-alcohol)
- [Zinc](https://lovi.care/skincare/sg/ingredients/zinc)
- [Zinc sulfate](https://lovi.care/skincare/sg/ingredients/zinc-sulfate)
- [Bleach](https://lovi.care/skincare/sg/ingredients/bleach)
- [Granactive retinoid](https://lovi.care/skincare/sg/ingredients/granactive-retinoid)
- [Hydroxypinacolone retinoate](https://lovi.care/skincare/sg/ingredients/hydroxypinacolone-retinoate)
- [Microcapsule](https://lovi.care/skincare/sg/ingredients/microcapsule)
- [Potassium hydroxide](https://lovi.care/skincare/sg/ingredients/potassium-hydroxide)
- [Cholesterol](https://lovi.care/skincare/sg/ingredients/cholesterol)
- [Phytosphingosine](https://lovi.care/skincare/sg/ingredients/phytosphingosine)
- [Betaine](https://lovi.care/skincare/sg/ingredients/betaine)
- [Phytosterol](https://lovi.care/skincare/sg/ingredients/phytosterol)
- [Citric acid](https://lovi.care/skincare/sg/ingredients/citric-acid)
- [Isopropyl alcohol](https://lovi.care/skincare/sg/ingredients/isopropyl-alcohol)
- [Beta-sitosterol](https://lovi.care/skincare/sg/ingredients/beta-sitosterol)
- [Behenyl alcohol](https://lovi.care/skincare/sg/ingredients/behenyl-alcohol)
- [Protease](https://lovi.care/skincare/sg/ingredients/protease)
- [Squalene](https://lovi.care/skincare/sg/ingredients/squalene)
- [Tri-ceramide complex](https://lovi.care/skincare/sg/ingredients/tri-ceramide-complex)
- [Baking soda](https://lovi.care/skincare/sg/ingredients/baking-soda)
- [GABA](https://lovi.care/skincare/sg/ingredients/gaba)
- [Theanine](https://lovi.care/skincare/sg/ingredients/theanine)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every ingredient with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this ingredient guide: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3
- United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3
- Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3
- Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3
- France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3
- Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3
- Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3
- Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3
- Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3
- Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3
- Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3 (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3