# Sesderma vs NIOD Page: https://lovi.care/skincare/sg/compare/sesderma-vs-niod The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore. Sesderma and NIOD are advanced skincare brands known for their meticulously engineered and sophisticated [serums](https://lovi.care/skincare/sg/ingredients/serum). The Spanish brand, founded in 1989 and owned by Grupo Sesderma since 2026, features botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types, with standout products like the Azelac RU Serum for acne-prone skin. Meanwhile, the Canadian brand, founded in 2015 and owned by The Estée Lauder Companies Inc. since 2021, delivers targeted results through balancing toners and thoughtful development that suit mature, sensitive, and dry skin types, featuring standout items such as Modulating Glucosides for acne-prone skin and [Superoxide Dismutase](https://lovi.care/skincare/sg/ingredients/superoxide-dismutase) Saccharide Mist for skin with dark spots. Both lines differ primarily in their formulation philosophies, as the former relies on synergistic botanical blends to refine texture and promote radiance, while the latter redefines modern skincare through scientifically rigorous research. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) NIOD is a Canadian skincare brand founded in 2015 and owned by The Estée Lauder Companies Inc. since 2021. [elcompanies.com](https://www.elcompanies.com/en/news-and-media/newsroom/press-releases/2024/06-03-2024-114511824) [glossy.co](https://www.glossy.co/beauty/estee-lauder-companies-completes-acquisition-of-deciem-the-ordinary-niod-for-1-7-billion/) [niod.com](https://niod.com/en-us/niod-about.html) [beautymatter.com](https://beautymatter.com/articles/niod-beautys-smartest-cult-brand-hits-sephora) This page compares some of the most popular Sesderma and NIOD products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg69be7feebc). ### Popular Sesderma vs NIOD products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit #### NIOD - [Modulating Glucosides](https://lovi.care/skincare/sg/p/niod/modulating-glucosides/for/mature-skin) — High fit - [Superoxide Dismutase Saccharide Mist](https://lovi.care/skincare/sg/p/niod/superoxide-dismutase-saccharide-mist/for/dry-sensitive-skin) — Average fit ## Questions and answers ### Sesderma or NIOD: which is better? NIOD may be better if you prefer fragrance-free formulas, as every product on this page lists no fragrance. Lovi rates NIOD Modulating Glucosides as a High fit for dry, sensitive, and mature skin types. ### What is the difference between Sesderma and NIOD? NIOD offers fragrance-free formulas with high Lovi fit for many skin types, whereas Sesderma includes fragrance in its [serum](https://lovi.care/skincare/sg/ingredients/serum) on this page. For acne-prone skin, Sesderma achieves a High fit with its Azelac RU Serum, while NIOD achieves an Average fit with Modulating Glucosides. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) [Skin Pharmacology and Physiology, 2012](https://pubmed.ncbi.nlm.nih.gov/22584263/) ### Which is more affordable, Sesderma or NIOD? The page facts do not provide pricing information for either Sesderma or NIOD, so affordability cannot be compared here. ### Which causes fewer breakouts, Sesderma or NIOD? NIOD provides a High Lovi fit for oily acne-prone skin with its Modulating Glucosides serum, whereas Sesderma's Azelac RU Serum offers an Average fit for that skin type. NIOD's products on this page list no fragrance, while Sesderma's serum contains fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Between Sesderma and NIOD, which brand was founded earlier and in which country? Sesderma was founded earlier in 1989 in Spain, whereas NIOD was founded in 2015 in Canada. ### How does the fragrance content compare between the Sesderma and NIOD products listed on the page? NIOD products on this page list no fragrance, whereas the Azelac RU Serum from Sesderma contains fragrance. This means shoppers looking to avoid added scents will find better options in the NIOD range. ### Which company currently owns NIOD and when was it acquired? NIOD is owned by The Estée Lauder Companies Inc. and was acquired in 2021. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin](https://pubmed.ncbi.nlm.nih.gov/22584263/) Glucosides · Skin Pharmacology and Physiology, 2012 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide](https://pubmed.ncbi.nlm.nih.gov/22916312/) Glucosides · The Journal of Clinical and Aesthetic Dermatology, 2012 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin](https://pubmed.ncbi.nlm.nih.gov/27460952/) Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016 - [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024 - [Use of the synthetic superoxide dismutase/catalase mimetic EUK-134 to compensate for seasonal antioxidant deficiency by reducing pre-existing lipid peroxides at the human skin surface](https://pubmed.ncbi.nlm.nih.gov/18492138/) Superoxide dismutase · International Journal of Cosmetic Science, 2004 - [Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study](https://pubmed.ncbi.nlm.nih.gov/29180884/) Pseudoalteromonas exopolysaccharides · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin](https://pubmed.ncbi.nlm.nih.gov/20883290/) Sodium salicylate · Journal of Cosmetic Dermatology, 2010 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma) - Canadian skincare: [NIOD](https://lovi.care/skincare/sg/brands/niod) ## More comparisons - [SKIN1004 vs Sesderma](https://lovi.care/skincare/sg/compare/skin1004-vs-sesderma) - [SKIN1004 vs NIOD](https://lovi.care/skincare/sg/compare/skin1004-vs-niod) - [Anua vs Sesderma](https://lovi.care/skincare/sg/compare/anua-vs-sesderma) - [Anua vs NIOD](https://lovi.care/skincare/sg/compare/anua-vs-niod) - [Medicube vs Sesderma](https://lovi.care/skincare/sg/compare/medicube-vs-sesderma) - [Medicube vs NIOD](https://lovi.care/skincare/sg/compare/medicube-vs-niod) - [The Ordinary vs Sesderma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-sesderma) - [The Ordinary vs NIOD](https://lovi.care/skincare/sg/compare/the-ordinary-vs-niod) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-sesderma) - [Beauty of Joseon vs NIOD](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-niod) - [COSRX vs Sesderma](https://lovi.care/skincare/sg/compare/cosrx-vs-sesderma) - [COSRX vs NIOD](https://lovi.care/skincare/sg/compare/cosrx-vs-niod) - [CeraVe vs Sesderma](https://lovi.care/skincare/sg/compare/cerave-vs-sesderma) - [CeraVe vs NIOD](https://lovi.care/skincare/sg/compare/cerave-vs-niod) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-sesderma) - [La Roche-Posay vs NIOD](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-niod) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/sg/compare/dr-althea-vs-sesderma) - [Dr. Althea vs NIOD](https://lovi.care/skincare/sg/compare/dr-althea-vs-niod) - [Some By Mi vs Sesderma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-sesderma) - [Some By Mi vs NIOD](https://lovi.care/skincare/sg/compare/some-by-mi-vs-niod) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/sesderma-vs-niod - United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-niod - Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-niod - Germany: https://lovi.care/skincare/de/compare/sesderma-vs-niod - France: https://lovi.care/skincare/fr/compare/sesderma-vs-niod - Italy: https://lovi.care/skincare/it/compare/sesderma-vs-niod - Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-niod - Spain: https://lovi.care/skincare/es/compare/sesderma-vs-niod - Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-niod - Australia: https://lovi.care/skincare/au/compare/sesderma-vs-niod - Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-niod (this page) - Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-niod - United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-niod