# Sesderma vs Heliocare

Page: https://lovi.care/skincare/sg/compare/sesderma-vs-heliocare

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Sesderma and Heliocare are two respected Spanish skincare brands known for their meticulously engineered formulas. The first is beloved for its advanced [serums](https://lovi.care/skincare/sg/ingredients/serum) featuring botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) and active compounds, suiting sensitive, hyperpigmented, and aging skin types best. The second brand is cherished for its protective sunscreens, which suit sensitive, oily, and blemish-prone skin through specialized textures that absorb quickly. Ultimately, both differ as the former refines skin texture and promotes radiance, while the latter delivers targeted daily defense without burdening the complexion.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

Heliocare is a Spanish skincare brand founded in 2001 and owned by Cantabria Labs.

This page compares some of the most popular Sesderma and Heliocare products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg34d9e04f15).

### Popular Sesderma vs Heliocare products

#### Heliocare

- [360° Gel Oil-Free SPF 50+](https://lovi.care/skincare/sg/p/heliocare/360-gel-oil-free-spf-50/for/dark-spots) — High fit

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

## Questions and answers

### Sesderma or Heliocare: which is better?

Heliocare and Sesderma are both a High fit for acne-prone skin and skin with dark spots on this page, but they serve different steps since Heliocare offers a sunscreen and Sesderma features a [serum](https://lovi.care/skincare/sg/ingredients/serum).

### What is the difference between Sesderma and Heliocare?

Sesderma offers Azelac RU Serum, which achieves a High Lovi fit for acne-prone skin, skin with dark spots, and combination skin, while Heliocare features 360° Gel Oil-Free SPF 50+, reaching a High fit for sensitive and mature skin types as well. Both brands are based in Spain, but Sesderma was founded in 1989 and Heliocare was established in 2001.

### Which is more affordable, Sesderma or Heliocare?

Neither Sesderma nor Heliocare is more affordable, as the products on this page do not list pricing information.

### Which causes fewer breakouts, Sesderma or Heliocare?

Both brands offer products on this page that achieve a High Lovi fit for acne-prone skin with the Azelac RU Serum and the 360° Gel Oil-Free SPF 50+. [Azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) helps in the treatment of acne vulgaris.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### In which country were Sesderma and Heliocare founded?

Both Sesderma and Heliocare were founded in Spain, with Sesderma established in 1989 and Heliocare following in 2001.

### Do the products listed for Sesderma and Heliocare contain fragrance?

Yes, all products on this page for both Sesderma and Heliocare contain fragrance.

### How does the Lovi fit level for dry skin compare between Sesderma's Azelac RU Serum and Heliocare's 360° Gel Oil-Free SPF 50+?

Lovi rates both Sesderma's Azelac RU Serum and Heliocare's 360° Gel Oil-Free SPF 50+ as having a low fit level for dry skin.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin](https://pubmed.ncbi.nlm.nih.gov/9361129/) Polypodium leucotomos leaf extract · Photodermatology, Photoimmunology & Photomedicine, 1997
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos](https://pubmed.ncbi.nlm.nih.gov/8897589/) Polypodium leucotomos leaf extract · Photodermatology, Photoimmunology & Photomedicine, 1996
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes](https://pubmed.ncbi.nlm.nih.gov/39778604/) 3-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Study of the soothing effects of troxerutin in alleviating skin sensitivity](https://pubmed.ncbi.nlm.nih.gov/38720512/) Troxerutin · Journal of Cosmetic Dermatology, 2024
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma)
- Spanish skincare: [Heliocare](https://lovi.care/skincare/sg/brands/heliocare)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-heliocare
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-heliocare
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-heliocare
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-heliocare
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- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-heliocare
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-heliocare
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-heliocare
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-heliocare
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-heliocare
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-heliocare (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-heliocare
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-heliocare