# Sesderma vs Hanhoo

Page: https://lovi.care/skincare/sg/compare/sesderma-vs-hanhoo

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Sesderma and Hanhoo are distinct skincare lines offering targeted [serums](https://lovi.care/skincare/sg/ingredients/serum) and carefully balanced formulas. The Spanish brand founded in 1989 is beloved for advanced, meticulously engineered formulas with botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types best, featuring the Azelac RU Serum for acne-prone skin. Meanwhile, the other brand is widely loved for its gentle yet effective nature, suiting sensitive, dry, and combination skin best with standout options like the Blemish Patch for acne-prone skin and the T-Zone Pore Patch for dark spots. They differ primarily in their heritage and specific active ingredients, yet both deliver reliable care for daily skincare routines.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and Hanhoo products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pge506fbb61b).

### Popular Sesderma vs Hanhoo products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Hanhoo

- [Blemish Patch](https://lovi.care/skincare/sg/p/hanhoo/blemish-patch/for/acne-prone-skin) — High fit — [S$29.59 at Amazon](https://www.amazon.sg/dp/B0F2JHGSCK?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [T-Zone Pore Patch](https://lovi.care/skincare/sg/p/hanhoo/t-zone-pore-patch/for/dark-spots) — Average fit

### Sesderma vs Hanhoo [serums](https://lovi.care/skincare/sg/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Hanhoo

- [Blemish Patch](https://lovi.care/skincare/sg/p/hanhoo/blemish-patch/for/acne-prone-skin) — High fit — [S$29.59 at Amazon](https://www.amazon.sg/dp/B0F2JHGSCK?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [T-Zone Pore Patch](https://lovi.care/skincare/sg/p/hanhoo/t-zone-pore-patch/for/dark-spots) — Average fit

## Questions and answers

### Sesderma or Hanhoo: which is better?

Hanhoo is better for dry, sensitive, or acne-prone skin types because Lovi rates its products on this page as High fit, whereas Sesderma is a High fit mainly for acne-prone skin, dark spots, and combination skin.

### What is the difference between Sesderma and Hanhoo?

Sesderma offers the Azelac RU [Serum](https://lovi.care/skincare/sg/ingredients/serum), which has a High Lovi fit for acne-prone skin, combination skin, and skin with dark spots, though it contains fragrance. Hanhoo features products like the Blemish Patch with a High Lovi fit across many skin types, and every product on this page lists no fragrance.

### Which is more affordable, Sesderma or Hanhoo?

This page does not provide pricing or affordability information for either Sesderma or Hanhoo.

### Which causes fewer breakouts, Sesderma or Hanhoo?

For acne-prone skin, Hanhoo achieves a High Lovi fit with its Blemish Patch, while Sesderma's Azelac RU Serum reaches a High fit. [Azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) helps manage acne vulgaris.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand has been established longer, Sesderma or Hanhoo?

Sesderma has been established longer, having been founded in 1989 in Spain, while Hanhoo was founded in 2008.

### Do Sesderma products contain fragrance, whereas Hanhoo products do not?

Yes, the products on this page from Sesderma contain fragrance, while Hanhoo products on this page list no fragrance.

### How does the Lovi fit level for dry skin compare between Sesderma's Azelac RU Serum and Hanhoo's Blemish Patch?

For dry skin, Lovi rates Sesderma's Azelac RU Serum as Low, whereas Hanhoo's Blemish Patch achieves a High fit level.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/17314442/) Melaleuca alternifolia tree oil leaf · Indian Journal of Dermatology, Venereology and Leprology, 2007
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Melaleuca alternifolia tree oil leaf, Aloe barbadensis leaf extract · Clinical Pharmacology, 2018
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study](https://pubmed.ncbi.nlm.nih.gov/25228478/) Melaleuca alternifolia tree oil leaf · Dermatology, 2014
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Melaleuca alternifolia tree oil leaf · Archives of Dermatological Research, 2022
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Tandem repeated irritation in aged skin induces distinct barrier perturbation and cytokine profile in vivo](https://pubmed.ncbi.nlm.nih.gov/22578221/) Toluene · The British Journal of Dermatology, 2012
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin](https://pubmed.ncbi.nlm.nih.gov/12125960/) Toluene · Acta Dermato-venereologica, 2002
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Protection from combination exposure](https://pubmed.ncbi.nlm.nih.gov/17312361/) Toluene · Current Problems in Dermatology, 2007

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma)
- Skincare: [Hanhoo](https://lovi.care/skincare/sg/brands/hanhoo)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-hanhoo
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-hanhoo
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-hanhoo
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-hanhoo (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-hanhoo
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