# Sesderma vs DOT & KEY

Page: https://lovi.care/skincare/sg/compare/sesderma-vs-dot-and-key

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Sesderma and DOT & KEY are international skincare brands offering distinct approaches to daily wellness. The Spanish pioneer, founded in 1989, is beloved for its advanced [serums](https://lovi.care/skincare/sg/ingredients/serum) and meticulously engineered formulas featuring botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) and active compounds that refine skin texture and promote a radiant complexion, making it best suited for sensitive, hyperpigmented, and aging skin types with standout items like the Azelac RU Serum for acne-prone skin. Conversely, the Indian label, established in 2018, is warmly embraced for its sensorially pleasing sunscreens and thoughtfully calibrated formulas that deliver protective daily care without heaviness, suiting balanced, combination, and normal skin best alongside reliable essentials like the WATERMELON COOLING SUNSCREEN for acne-prone skin. Ultimately, the former utilizes synergistic actives for deep correction, while both differ by focusing on lightweight textures versus advanced dermatological engineering.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

DOT & KEY is an Indian skincare brand founded in 2018 and owned by FSN E-Commerce Ventures Limited since 2021.

This page compares some of the most popular Sesderma and DOT & KEY products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgb031bfec56).

### Popular Sesderma vs DOT & KEY products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### DOT & KEY

- [WATERMELON COOLING SUNSCREEN](https://lovi.care/skincare/sg/p/dot-and-key/watermelon-cooling-sunscreen/for/combination-skin) — Average fit

## Questions and answers

### Sesderma or DOT & KEY: which is better?

Neither brand is universally better, as Sesderma earns a High Lovi fit for acne-prone skin and dark spots with its Azelac RU [Serum](https://lovi.care/skincare/sg/ingredients/serum), while DOT & KEY maintains average fits across all skin types with its fragrance-free WATERMELON COOLING SUNSCREEN.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What is the difference between Sesderma and DOT & KEY?

Sesderma earns a High Lovi fit for acne-prone skin and dark spots with its Azelac RU Serum, whereas DOT & KEY offers average Lovi fit levels across all skin types with its WATERMELON COOLING SUNSCREEN. Additionally, the products on this page from DOT & KEY contain no fragrance, while the Sesderma product includes fragrance.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which is more affordable, Sesderma or DOT & KEY?

Neither Sesderma nor DOT & KEY can be compared for affordability on this page because pricing information is not provided.

### Which causes fewer breakouts, Sesderma or DOT & KEY?

DOT & KEY and Sesderma both have average fit for acne-prone skin with the products on this page, while Sesderma also has a high fit for acne-prone skin with Azelac RU Serum. [Azelaic acid](https://lovi.care/skincare/sg/ingredients/azelaic-acid) helps reduce acne.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Where and when were Sesderma and DOT & KEY founded?

Sesderma was founded in Spain in 1989, while DOT & KEY was founded in India in 2018.

### Which brand uses fragrance in its products, Sesderma or DOT & KEY?

Sesderma uses fragrance in its Azelac RU Serum on this page, whereas all products from DOT & KEY list no fragrance.

### How does the Lovi fit level for dry skin compare between Sesderma's Azelac RU Serum and DOT & KEY's Watermelon Cooling Sunscreen?

DOT & KEY's Watermelon Cooling Sunscreen has an Average Lovi fit for dry skin, while Sesderma's Azelac RU Serum only has a Low fit for dry skin.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Hyaluronic acid · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [In vivo and in vitro evaluation of octyl methoxycinnamate liposomes](https://pubmed.ncbi.nlm.nih.gov/24376350/) Ethylhexyl methoxycinnamate · International Journal of Nanomedicine, 2013
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin](https://pubmed.ncbi.nlm.nih.gov/39138602/) Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl methoxycinnamate · Archives of Dermatological Research, 2024
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma)
- Indian skincare: [DOT & KEY](https://lovi.care/skincare/sg/brands/dot-and-key)

## More comparisons

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- [SKIN1004 vs DOT & KEY](https://lovi.care/skincare/sg/compare/skin1004-vs-dot-and-key)
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- [Anua vs DOT & KEY](https://lovi.care/skincare/sg/compare/anua-vs-dot-and-key)
- [Medicube vs Sesderma](https://lovi.care/skincare/sg/compare/medicube-vs-sesderma)
- [Medicube vs DOT & KEY](https://lovi.care/skincare/sg/compare/medicube-vs-dot-and-key)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs DOT & KEY](https://lovi.care/skincare/sg/compare/the-ordinary-vs-dot-and-key)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-sesderma)
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- [COSRX vs Sesderma](https://lovi.care/skincare/sg/compare/cosrx-vs-sesderma)
- [COSRX vs DOT & KEY](https://lovi.care/skincare/sg/compare/cosrx-vs-dot-and-key)
- [CeraVe vs Sesderma](https://lovi.care/skincare/sg/compare/cerave-vs-sesderma)
- [CeraVe vs DOT & KEY](https://lovi.care/skincare/sg/compare/cerave-vs-dot-and-key)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs DOT & KEY](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-dot-and-key)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/sg/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs DOT & KEY](https://lovi.care/skincare/sg/compare/dr-althea-vs-dot-and-key)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs DOT & KEY](https://lovi.care/skincare/sg/compare/some-by-mi-vs-dot-and-key)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-dot-and-key
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-dot-and-key
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-dot-and-key
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-dot-and-key
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- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-dot-and-key
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-dot-and-key
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-dot-and-key
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-dot-and-key
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-dot-and-key
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-dot-and-key (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-dot-and-key
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-dot-and-key