# Sesderma vs Biluma

Page: https://lovi.care/skincare/sg/compare/sesderma-vs-biluma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Sesderma and Biluma are dermatological lines offering specialized care for diverse complexions. The Spanish brand is known for advanced [serums](https://lovi.care/skincare/sg/ingredients/serum) featuring botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) and active compounds that refine texture, suiting sensitive, hyperpigmented, and aging skin. Meanwhile, the Indian brand is celebrated for sophisticated formulations that deliver daily balance, serving combination, sensitive, and dry skin types best. While both feature standout products designed for acne-prone concerns, the former relies on meticulously engineered formulas for radiance, whereas the latter provides carefully crafted creams for reliable everyday nourishment.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

Biluma is an Indian skincare brand founded in 2014 and owned by Galderma Group AG.

[galderma.com](https://www.galderma.com/sites/default/files/2026-03/galderma_ar_2025_consolidated-doc_8b_260304_-_full.pdf)

This page compares some of the most popular Sesderma and Biluma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg1c8f93eebb).

### Popular Sesderma vs Biluma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Biluma

- [Cream](https://lovi.care/skincare/sg/p/biluma/cream/for/combination-skin) — Average fit

### Sesderma vs Biluma [serums](https://lovi.care/skincare/sg/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Biluma

- [Cream](https://lovi.care/skincare/sg/p/biluma/cream/for/combination-skin) — Average fit

## Questions and answers

### Sesderma or Biluma: which is better?

For skin with dark spots, Lovi gives Sesderma's Azelac RU [Serum](https://lovi.care/skincare/sg/ingredients/serum) a High fit, while Biluma Cream gets an Average fit. Biluma's products on this page list no fragrance in their ingredients, whereas the Sesderma serum contains fragrance.

### What is the difference between Sesderma and Biluma?

Sesderma offers Azelac RU Serum which has a High Lovi fit for acne-prone skin and skin with dark spots, whereas Biluma Cream has an Average fit for those skin types. Biluma products on this page list no fragrance, while Sesderma includes fragrance in its serum.

### Which is more affordable, Sesderma or Biluma?

Neither Sesderma nor Biluma lists pricing information for the products on this page, so affordability cannot be compared.

### Which causes fewer breakouts, Sesderma or Biluma?

For acne-prone skin, Sesderma has a High Lovi fit with its Azelac RU Serum, whereas Biluma has an Average fit, though Azelac RU Serum contains fragrance while Biluma products list no fragrance.

### Where and when were the parent companies of Sesderma and Biluma founded?

Sesderma's parent company was founded in Spain in 1989, while Biluma's parent company was founded in India in 2014.

### Which brand offers a serum formulated with fragrance, Sesderma or Biluma?

Sesderma offers a serum formulated with fragrance on this page, whereas Biluma products on this page list no fragrance in their ingredients.

### How does the Lovi fit level for skin with dark spots compare between Sesderma's Azelac RU Serum and Biluma Cream?

For skin with dark spots, Sesderma has a High Lovi fit level with Azelac RU Serum, while Biluma Cream has an Average fit level.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations](https://pubmed.ncbi.nlm.nih.gov/26119285/) Arbutin · Journal of Cosmetic Dermatology, 2015
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha arbutin · Heliyon, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma)
- Indian skincare: [Biluma](https://lovi.care/skincare/sg/brands/biluma)

## More comparisons

- [SKIN1004 vs Sesderma](https://lovi.care/skincare/sg/compare/skin1004-vs-sesderma)
- [SKIN1004 vs Biluma](https://lovi.care/skincare/sg/compare/skin1004-vs-biluma)
- [Anua vs Sesderma](https://lovi.care/skincare/sg/compare/anua-vs-sesderma)
- [Anua vs Biluma](https://lovi.care/skincare/sg/compare/anua-vs-biluma)
- [Medicube vs Sesderma](https://lovi.care/skincare/sg/compare/medicube-vs-sesderma)
- [Medicube vs Biluma](https://lovi.care/skincare/sg/compare/medicube-vs-biluma)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs Biluma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-biluma)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-sesderma)
- [Beauty of Joseon vs Biluma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-biluma)
- [COSRX vs Sesderma](https://lovi.care/skincare/sg/compare/cosrx-vs-sesderma)
- [COSRX vs Biluma](https://lovi.care/skincare/sg/compare/cosrx-vs-biluma)
- [CeraVe vs Sesderma](https://lovi.care/skincare/sg/compare/cerave-vs-sesderma)
- [CeraVe vs Biluma](https://lovi.care/skincare/sg/compare/cerave-vs-biluma)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs Biluma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-biluma)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/sg/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs Biluma](https://lovi.care/skincare/sg/compare/dr-althea-vs-biluma)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs Biluma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-biluma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-biluma
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-biluma
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-biluma
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-biluma
- France: https://lovi.care/skincare/fr/compare/sesderma-vs-biluma
- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-biluma
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-biluma
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-biluma
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-biluma
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-biluma
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-biluma (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-biluma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-biluma