# Pair vs Sesderma Page: https://lovi.care/skincare/sg/compare/pair-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore. Pair and Sesderma are trusted skincare brands, featuring targeted and advanced [serums](https://lovi.care/skincare/sg/ingredients/serum) with meticulously crafted formulas. The Japanese brand suits acne-prone skin best, featuring the Acne Cream W for stubborn blemishes, while the Spanish brand suits sensitive, hyperpigmented, and aging skin types best, featuring the Azelac RU Serum. Both brands help restore balance and clarity, though they differ in their specific botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) and active compounds for radiant complexions. Pair is a Japanese skincare brand founded in 2000 and owned by Lion Corporation since 2004. [ja.wikipedia.org](https://ja.wikipedia.org/wiki/%E3%83%A9%E3%82%A4%E3%82%AA%E3%83%B3%E8%A3%BD%E5%93%81%E4%B8%80%E8%A6%A7) [beautymatter.com](https://beautymatter.com/articles/courtin-family-takes-majority-stake-in-pai-skincare) Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular Pair and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgf6ca7670c9). ### Popular Pair vs Sesderma products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit #### Pair - [Acne Cream W](https://lovi.care/skincare/sg/p/pair/acne-cream-w/for/combination-skin) — Average fit ### Pair vs Sesderma [serums](https://lovi.care/skincare/sg/ingredients/serum) and treatments #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit #### Pair - [Acne Cream W](https://lovi.care/skincare/sg/p/pair/acne-cream-w/for/combination-skin) — Average fit ## Questions and answers ### Pair or Sesderma: which is better? Sesderma offers a High fit for acne-prone skin and skin with dark spots, whereas Pair provides an Average fit across these types. Lovi rates Sesderma's Azelac RU [Serum](https://lovi.care/skincare/sg/ingredients/serum) with fragrance, while the products on this page from Pair list no fragrance. ### What is the difference between Pair and Sesderma? Sesderma Azelac RU Serum has a High Lovi fit for acne-prone skin and skin with dark spots, whereas Pair Acne Cream W has an Average fit for those skin types. Additionally, every product on this page by Pair lists no fragrance, while Sesderma includes fragrance in its serum. ### Which is more affordable, Pair or Sesderma? The page facts do not mention pricing or affordability for either Pair or Sesderma. ### Which causes fewer breakouts, Pair or Sesderma? Sesderma offers a high fit for acne-prone skin with its Azelac RU Serum, whereas Pair products on this page receive only average fits for acne-prone and oily skin-types. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Which brand has been established longer, Pair or Sesderma? Sesderma has been established longer than Pair, having been founded in Spain in 1989 compared to Pair, which was founded in Japan in 2000. ### Do products from Pair or Sesderma contain fragrance? Pair products on this page list no fragrance in their ingredients, whereas Sesderma's Azelac RU Serum contains fragrance. ### Which brand offers a serum that is rated High for skin with dark spots? Sesderma offers Azelac RU Serum, which Lovi rates High for skin with dark spots. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) 3-butylene glycol · International Journal of Cosmetic Science, 2024 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Japanese skincare: [Pair](https://lovi.care/skincare/sg/brands/pair) - Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma) ## More comparisons - [SKIN1004 vs Pair](https://lovi.care/skincare/sg/compare/skin1004-vs-pair) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/sg/compare/skin1004-vs-sesderma) - [Anua vs Pair](https://lovi.care/skincare/sg/compare/anua-vs-pair) - [Anua vs Sesderma](https://lovi.care/skincare/sg/compare/anua-vs-sesderma) - [Medicube vs Pair](https://lovi.care/skincare/sg/compare/medicube-vs-pair) - [Medicube vs Sesderma](https://lovi.care/skincare/sg/compare/medicube-vs-sesderma) - [The Ordinary vs Pair](https://lovi.care/skincare/sg/compare/the-ordinary-vs-pair) - [The Ordinary vs Sesderma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs Pair](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-pair) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs Pair](https://lovi.care/skincare/sg/compare/cosrx-vs-pair) - [COSRX vs Sesderma](https://lovi.care/skincare/sg/compare/cosrx-vs-sesderma) - [CeraVe vs Pair](https://lovi.care/skincare/sg/compare/cerave-vs-pair) - [CeraVe vs Sesderma](https://lovi.care/skincare/sg/compare/cerave-vs-sesderma) - [La Roche-Posay vs Pair](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-pair) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs Pair](https://lovi.care/skincare/sg/compare/dr-althea-vs-pair) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/sg/compare/dr-althea-vs-sesderma) - [Some By Mi vs Pair](https://lovi.care/skincare/sg/compare/some-by-mi-vs-pair) - [Some By Mi vs Sesderma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/pair-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/pair-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/pair-vs-sesderma - Germany: https://lovi.care/skincare/de/compare/pair-vs-sesderma - France: https://lovi.care/skincare/fr/compare/pair-vs-sesderma - Italy: https://lovi.care/skincare/it/compare/pair-vs-sesderma - Netherlands: https://lovi.care/skincare/nl/compare/pair-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/pair-vs-sesderma - Canada: https://lovi.care/skincare/ca/compare/pair-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/pair-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/pair-vs-sesderma (this page) - Saudi Arabia: https://lovi.care/skincare/sa/compare/pair-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/pair-vs-sesderma