La Roche-Posay vs Yepoda

Questions and answers

Research behind their key ingredients

• Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin

  Retinol · The Journal of Investigative Dermatology, 2000

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage

  Sodium hyaluronate · Drug Delivery, 2017

• Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

  Niacinamide · Antioxidants, 2021

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Sodium hyaluronate · Dermatologic Therapy, 2022

• Topical use of dexpanthenol in skin disorders

  Panthenol, Vitamin b5 · American Journal of Clinical Dermatology, 2002

• Improvement of naturally aged skin with vitamin A (retinol)

  Retinol · Archives of Dermatology, 2007

• Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome

  Lactobacillus · International Journal of Medical Sciences, 2021

• Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial

  Tocopherol, Ascorbic acid, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020

• Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo

  Retinol · International Journal of Cosmetic Science, 2017

• Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

  Retinol · The British Journal of Dermatology, 2019

• Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes

  Phenylethyl resorcinol · Asian Journal of Pharmaceutical Sciences, 2018

• Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract

  Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016

• Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin

  Squalane · Scientific Reports, 2020

• Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study

  Ascorbic acid · Clinical Oral Investigations, 2021

• Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications

  Phenylethyl resorcinol · BioMed Research International, 2017

• Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin

  Ceramide-3, Ceramide np · International Journal of Dermatology, 2008

• Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation

  Tocopherol, Ascorbic acid, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020

• Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial

  Lactobacillus · Journal of Cosmetic Dermatology, 2022

• Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin

  Centella asiatica leaf extract · Experimental Dermatology, 2008

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

  Niacinamide · Journal of Cosmetic Dermatology, 2021

• The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial

  Madecassoside · Journal of Alternative and Complementary Medicine, 2020

• Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison

  Adapalene usp retinoid acne treatment, Adapalene · American Journal of Clinical Dermatology, 2018

• Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug

  Adapalene, Adapalene usp retinoid acne treatment · American Journal of Clinical Dermatology, 2022

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol, Vitamin b5 · The Journal of Dermatological Treatment, 2017

• Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

  Niacinamide · Scientific Reports, 2024

• A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

  Salicylic acid · BioMed Research International, 2020

• Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration

  Adenosine · International Journal of Cosmetic Science, 2018

• A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial

  Adapalene, Adapalene usp retinoid acne treatment · Archives of Dermatological Research, 2022

• Fermented pomegranate extracts protect against oxidative stress and aging of skin

  Punica granatum fruit extract · Journal of Cosmetic Dermatology, 2022

• Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial

  Panthenol, Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study

  Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019

• Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

  Centella asiatica leaf extract, Madecassoside · Molecules, 2023

• A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne

  Gluconolactone · The Australasian Journal of Dermatology, 1992

• Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study

  Salicylic acid · Journal of Cosmetic Dermatology, 2024

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach

  Zinc · Journal of Controlled Release, 2025

• The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro

  Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023

• A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid

  Ceramide-3, Ceramide np · Skin Pharmacology and Physiology, 2022

• Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study

  Argilla · Forschende Komplementarmedizin, 2012

• Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial

  Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019

• A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide

  Salicylic acid · Journal of Drugs in Dermatology, 2023

• Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin

  Neurosensine · Journal of the European Academy of Dermatology and Venereology, 2016

• A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial

  Ginkgo biloba extract · Clinical, Cosmetic and Investigational Dermatology, 2015

• 2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study

  2-mercaptonicotinoyl glycine · Journal of Cosmetic Dermatology, 2024

• A Bayesian network meta-analysis of 14 molecules inhibiting UV daylight-induced pigmentation

  2-mercaptonicotinoyl glycine · Journal of the European Academy of Dermatology and Venereology, 2024

• Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials

  Adapalene · Journal of the American Academy of Dermatology, 2023

• Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial

  Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020

• Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial

  Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022

• Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function

  Propanediol · International Journal of Cosmetic Science, 2024

• Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study

  Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023

• Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)

  Sodium laureth sulfate · Food and Chemical Toxicology, 2001

• Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris

  Capryloyl salicylic acid, Citric acid · Journal of Cosmetic Dermatology, 2021

• Amino acid complex (AAComplex) benefits in cosmetic products: In vitro and in vivo clinical studies

  Complex amino acid · Journal of Cosmetic Dermatology, 2022

• Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin

  Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2008

• Comparative benefit of two thermal spring waters after photodynamic therapy procedure

  La roche-posay thermal spring water · Journal of Cosmetic Dermatology, 2007

• Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations

  Complex amino acid · International Journal of Molecular Sciences, 2021

• Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects

  Punica granatum extract · Postepy Dermatologii I Alergologii, 2014

• Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment

  Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024

• Comprehensive assessment of the efficacy and safety of a clay mask in oily and acne skin

  Argilla · Skin Research and Technology, 2023

• A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin

  Vitreoscilla ferment · Journal of the European Academy of Dermatology and Venereology, 2022

• Comparison of methods for assessing photoprotection against ultraviolet A in vivo

  Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987

• Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters

  Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019

• Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin

  Copper tripeptide-1 · Archives of Facial Plastic Surgery, 2006

• A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants

  Dimethicone · Ostomy/wound Management, 2005

• Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters

  Octocrylene · Antioxidants, 2025

• A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo

  Shea butter · Journal of Cosmetic Dermatology, 2022

• Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles

  Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021

• Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid

  Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010

• Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials

  2-mercaptonicotinoyl glycine · Frontiers in Pharmacology, 2025

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol, Vitamin b5 · Journal of Cosmetic Dermatology, 2025

• A multicenter, double-blind study to evaluate the efficacy and safety of 2 treatments in participants with mild to moderate acne vulgaris

  Micro-exfoliating lha · Cutis, 2012

• Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study

  Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026

• Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays

  Propanediol · Molecules, 2021

• Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin

  Prebiotic thermal water, La roche-posay thermal spring water, Thermal spring water · Journal of the European Academy of Dermatology and Venereology, 2020

• Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris

  Capryloyl salicylic acid · Journal of Drugs in Dermatology, 2013

• Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid

  Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998

• Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

  Caprylic capric triglyceride · Life, 2023

• Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery

  Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022

• Evaulation of irritation potential of surfactant mixtures

  Sodium laureth sulfate · International Journal of Cosmetic Science, 1999

• Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights

  Punica granatum extract · Food Science & Nutrition, 2025

• Poly-γ-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model

  Polyglutamic acid · International Journal of Molecular Sciences, 2025

• Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers

  Dimethicone · Military Medicine, 2024

• Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study

  Prebiotic thermal water, La roche-posay thermal spring water, Thermal spring water, La roche-posay prebiotic thermal water, Thermal water · The Medical Journal of Malaysia, 2024

• Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial

  Micro-exfoliating lha · Journal of Cosmetic Dermatology, 2023

• Facial disbiosis and UV filters

  Ethylhexyl salicylate · Archives of Dermatological Research, 2024

• Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study

  Zinc gluconate · Journal of Cosmetic Dermatology, 2026

• A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

  Pha polyhydroxy acid · Cutis, 2004

• Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial

  Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

• Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial

  Shea butter, Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025

• Retrospective Review of Dermal Safety Studies of Organic Sunscreens

  Ethylhexyl salicylate, Homosalate · Journal of Drugs in Dermatology, 2025

• Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study

  Sodium laureth sulfate · International Journal of Pharmaceutics, 2026

• Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters

  Gluconolactone · Skin Research and Technology, 2023

• Effects of an ultraviolet B radiation absorber on photocarcinogenesis in hairless albino mice

  Ethylhexyl triazone · Skin Pharmacology and Physiology, 2009

• In vitro analysis of immunoprotective effects of topical sunscreens

  Ethylhexyl triazone · Toxicology in Vitro, 1994

• Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu

  Copper tripeptide-1 · Skin Research and Technology, 2026

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.