# Hada Labo vs Mesoestetic

Page: https://lovi.care/skincare/sg/compare/hada-labo-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Hada Labo and Mesoestetic are two celebrated skincare brands that offer distinct approaches to daily wellness. The Japanese brand is known for its hydrating toners, gentle makeup removers, and nourishing moisturizers, while the Spanish brand is beloved for its targeted [serums](https://lovi.care/skincare/sg/ingredients/serum) and meticulously crafted formulas. The first brand suits dry skin and combination skin best, whereas the second brand suits mature, sensitive, and uneven skin best. Ultimately, they differ in their regional origins, founding years, and signature active ingredients.

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular Hada Labo and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg8fdb9bcce2).

### Popular Hada Labo vs Mesoestetic products

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/sg/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [S$25.60 at Amazon](https://www.amazon.sg/dp/B086FGJ475?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Gokujun Premium](https://lovi.care/skincare/sg/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/sg/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit — [S$42.42 at Amazon](https://www.amazon.sg/dp/B08WSCPL38?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/sg/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/sg/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/sg/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit — [S$42.42 at Amazon](https://www.amazon.sg/dp/B08WSCPL38?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/sg/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### Hada Labo or Mesoestetic: which is better?

Hada Labo is a better fit for most people on this page, as its products achieve Superior or High Lovi fit levels across dry, sensitive, and acne-prone skin types. [Hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) helps provide deep hydration, although some reviewers mention sticky finishes and breakouts.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Hada Labo and Mesoestetic?

Hada Labo features multiple products on this page with High to Superior Lovi fit levels for dry and sensitive skin, while Mesoestetic offers Cosmelan 2, which has Low fit levels for dry and dry sensitive skin. Hada Labo products use hyaluronic acid to help provide deep hydration, which may improve skin quality.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Hada Labo or Mesoestetic?

Hada Labo offers value and versatility as noted by reviewers for the products on this page, whereas Mesoestetic has no information listed on affordability.

### Which causes fewer breakouts, Hada Labo or Mesoestetic?

Hada Labo is unlikely to cause breakouts for most users, though some reviewers on the page mention breakouts and clogged pores. Mesoestetic has only one product on this page with lower fit levels for acne-prone skin, but Lovi rates it as average.

### Which brand has been around longer and in which country was it founded?

Mesoestetic has been around longer, having been founded in Spain in 1984, whereas Hada Labo was founded in Japan in 2004.

### Do any products from either Hada Labo or Mesoestetic contain fragrance?

Every product on this page from both Hada Labo and Mesoestetic lists no fragrance in its ingredients.

### What are the main pros and cons that reviewers mention about Hada Labo products?

Reviewers mostly mention deep hydration and moisturization as a main pro of the products on this page, alongside gentle and fragrance-free formulations, value and versatility, lightweight and fast-absorbing toners, and brightening and dark spot reduction. On the downside, reviewers often mention sticky and tacky finishes, application and environmental issues, as well as breakouts and clogged pores.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026

## The brands

- Japanese skincare: [Hada Labo](https://lovi.care/skincare/sg/brands/hada-labo)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/sg/brands/mesoestetic)

## More comparisons

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- [The Ordinary vs Hada Labo](https://lovi.care/skincare/sg/compare/the-ordinary-vs-hada-labo)
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- [CeraVe vs Hada Labo](https://lovi.care/skincare/sg/compare/cerave-vs-hada-labo)
- [CeraVe vs Mesoestetic](https://lovi.care/skincare/sg/compare/cerave-vs-mesoestetic)
- [La Roche-Posay vs Hada Labo](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-hada-labo)
- [La Roche-Posay vs Mesoestetic](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-mesoestetic)
- [Dr. Althea vs Hada Labo](https://lovi.care/skincare/sg/compare/dr-althea-vs-hada-labo)
- [Dr. Althea vs Mesoestetic](https://lovi.care/skincare/sg/compare/dr-althea-vs-mesoestetic)
- [Some By Mi vs Hada Labo](https://lovi.care/skincare/sg/compare/some-by-mi-vs-hada-labo)
- [Some By Mi vs Mesoestetic](https://lovi.care/skincare/sg/compare/some-by-mi-vs-mesoestetic)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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