# Hada Labo vs BIOEFFECT

Page: https://lovi.care/skincare/sg/compare/hada-labo-vs-bioeffect

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Hada Labo and BIOEFFECT are two distinct skincare lines known for their advanced formulas and targeted offerings. The Japanese brand provides hydrating toners, gentle makeup removers, and nourishing moisturizers that suit dry skin and combination skin best, with standout products like the Gokujyun Lotion for acne-prone skin, the Shirojyun Premium Whitening Lotion for dark spots, and the Gokujun Premium for mature skin. Conversely, the Icelandic brand is cherished for its targeted [serums](https://lovi.care/skincare/sg/ingredients/serum) that suit mature skin types best, featuring the EGF Serum for acne-prone skin. While both deliver reliable hydration and restorative daily support, they differ in their primary product types and specific formulations.

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

This page compares some of the most popular Hada Labo and BIOEFFECT products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg5088085fce).

### Popular Hada Labo vs BIOEFFECT products

#### BIOEFFECT

- [EGF Serum](https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/dry-skin) — Superior fit

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/sg/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [S$25.60 at Amazon](https://www.amazon.sg/dp/B086FGJ475?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Gokujun Premium](https://lovi.care/skincare/sg/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/sg/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit — [S$42.42 at Amazon](https://www.amazon.sg/dp/B08WSCPL38?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/sg/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/sg/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/sg/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit — [S$42.42 at Amazon](https://www.amazon.sg/dp/B08WSCPL38?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)

## Questions and answers

### Hada Labo or BIOEFFECT: which is better?

Both brands are great choices depending on your budget and routine, with Hada Labo offering a wide range of deeply hydrating toners and cleansers while BIOEFFECT provides a single high-end EGF [Serum](https://lovi.care/skincare/sg/ingredients/serum). [Hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) helps improve skin quality and signs of skin aging.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Hada Labo and BIOEFFECT?

Hada Labo offers multiple fragrance-free products on this page featuring hyaluronic acid that are rated Superior for dry skin, whereas BIOEFFECT features the EGF Serum with a Superior fit for dry skin, dry sensitive skin, and mature skin. Both brands list no fragrance in their products on this page.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/) [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Which is more affordable, Hada Labo or BIOEFFECT?

The provided page facts do not contain pricing information, so a direct comparison of affordability between Hada Labo and BIOEFFECT cannot be made.

### Which causes fewer breakouts, Hada Labo or BIOEFFECT?

Hada Labo products on this page list breakouts and clogged pores as a negative reviewer mention, while BIOEFFECT EGF Serum has a High Lovi fit for acne-prone skin with no breakout reports on this page.

### Which brand was founded earlier and in which country?

Hada Labo was founded earlier in 2004 in Japan, while BIOEFFECT was founded in 2010.

### Do either of these brands include fragrance in their skincare products?

Both brands offer fragrance-free products on this page, as every item from Hada Labo and BIOEFFECT lists no fragrance in its ingredients.

### Which skin types does Hada Labo's Gokujyun Lotion fit best according to its Lovi fit levels?

According to its Lovi fit levels, Hada Labo's Gokujyun Lotion fits dry skin and dry sensitive skin best with a Superior fit.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Sodium hyaluronate · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026

## The brands

- Japanese skincare: [Hada Labo](https://lovi.care/skincare/sg/brands/hada-labo)
- Skincare: [BIOEFFECT](https://lovi.care/skincare/sg/brands/bioeffect)

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- [The Ordinary vs Hada Labo](https://lovi.care/skincare/sg/compare/the-ordinary-vs-hada-labo)
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- [La Roche-Posay vs Hada Labo](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-hada-labo)
- [La Roche-Posay vs BIOEFFECT](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-bioeffect)
- [Dr. Althea vs Hada Labo](https://lovi.care/skincare/sg/compare/dr-althea-vs-hada-labo)
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- [Some By Mi vs Hada Labo](https://lovi.care/skincare/sg/compare/some-by-mi-vs-hada-labo)
- [Some By Mi vs BIOEFFECT](https://lovi.care/skincare/sg/compare/some-by-mi-vs-bioeffect)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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