# Galderma vs Sesderma Page: https://lovi.care/skincare/sg/compare/galderma-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore. Galderma and Sesderma are distinguished skincare houses originating from Switzerland and Spain, respectively. The Swiss brand specializes in targeted treatments like the Epiduo Gel and Benzac AC variants, which suit acne-prone and mature complexions, while the Spanish brand is beloved for advanced [serums](https://lovi.care/skincare/sg/ingredients/serum) with botanical [extracts](https://lovi.care/skincare/sg/ingredients/extract) that care for sensitive, hyperpigmented, and aging skin. Both offer carefully engineered formulas, yet they differ primarily in their heritage and specific active compounds designed to address distinct dermatological needs. Galderma is a Swiss skincare brand founded in 1981 and owned by Galderma Group AG. [en.wikipedia.org](https://en.wikipedia.org/wiki/Galderma) Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular Galderma and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg1c05c8e9dc). ### Popular Galderma vs Sesderma products #### Galderma - [Epiduo Gel](https://lovi.care/skincare/sg/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [Benzac AC 5](https://lovi.care/skincare/sg/p/galderma/benzac-ac-5/for/oily-acne-prone-skin) — High fit - [Benzac AC Mild Strength 2.5% Acne Gel](https://lovi.care/skincare/sg/p/galderma/benzac-ac-mild-strength-2-5-acne-gel/for/oily-acne-prone-skin) — High fit #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit ### Galderma vs Sesderma [serums](https://lovi.care/skincare/sg/ingredients/serum) and treatments #### Galderma - [Epiduo Gel](https://lovi.care/skincare/sg/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [Benzac AC 5](https://lovi.care/skincare/sg/p/galderma/benzac-ac-5/for/oily-acne-prone-skin) — High fit - [Benzac AC Mild Strength 2.5% Acne Gel](https://lovi.care/skincare/sg/p/galderma/benzac-ac-mild-strength-2-5-acne-gel/for/oily-acne-prone-skin) — High fit #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit ## Questions and answers ### Galderma or Sesderma: which is better? Galderma is better for clearing acne, with products on this page earning a High Lovi fit for oily acne-prone skin. However, reviewers note that Galderma [serums](https://lovi.care/skincare/sg/ingredients/serum) may cause severe dryness, peeling, and irritation. Azelac RU Serum by Sesderma achieves a High Lovi fit for skin with dark spots. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### What is the difference between Galderma and Sesderma? Galderma offers fragrance-free acne-clearing serums that achieve a High Lovi fit for oily and acne-prone skin, while Sesderma provides a serum with fragrance that achieves a High Lovi fit for dark spots and combination skin. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Which is more affordable, Galderma or Sesderma? The products on this page for both Galderma and Sesderma do not list pricing information, so affordability cannot be compared. ### Which causes fewer breakouts, Galderma or Sesderma? Galderma has a High Lovi fit for acne-prone skin with the products on this page, whereas Sesderma also has a High Lovi fit for acne-prone skin with Azelac RU Serum. Both brands help clear acne, though Galderma may cause severe dryness, peeling, and irritation. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Between Galderma and Sesderma, which brand offers fragrance-free products? Galderma offers fragrance-free options because every product on this page lists no fragrance in its ingredients. In contrast, the Azelac RU Serum by Sesderma includes fragrance. ### How do the founding countries and years of Galderma and Sesderma compare? Galderma was founded in Switzerland in 1981, whereas Sesderma was founded in Spain in 1989. ### Which brand has products specifically suited for oily acne-prone skin with a High Lovi fit level? Galderma has products on this page specifically suited for oily acne-prone skin with a High Lovi fit level, such as Epiduo Gel and Benzac AC 5. Sesderma's Azelac RU Serum holds an Average Lovi fit level for this skin type. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Topical benzoyl peroxide for acne](https://pubmed.ncbi.nlm.nih.gov/32175593/) Benzoyl peroxide, Benzoyl peroxide 25mg g · The Cochrane Database of Systematic Reviews, 2020 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure](https://pubmed.ncbi.nlm.nih.gov/33545336/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of Shoulder and Elbow Surgery, 2021 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Benzoyl peroxide, Benzoyl peroxide 25mg g · American Journal of Clinical Dermatology, 2022 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15](https://pubmed.ncbi.nlm.nih.gov/32224894/) Silicon dioxide · Antioxidants, 2020 - [Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection](https://pubmed.ncbi.nlm.nih.gov/32395645/) Silicon dioxide · Heliyon, 2020 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 - [Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies](https://pubmed.ncbi.nlm.nih.gov/37356627/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of the American Academy of Dermatology, 2023 - [Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation](https://pubmed.ncbi.nlm.nih.gov/37367119/) Carbomer 940 · Gels, 2023 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Swiss skincare: [Galderma](https://lovi.care/skincare/sg/brands/galderma) - Spanish skincare: [Sesderma](https://lovi.care/skincare/sg/brands/sesderma) ## More comparisons - [SKIN1004 vs Galderma](https://lovi.care/skincare/sg/compare/skin1004-vs-galderma) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/sg/compare/skin1004-vs-sesderma) - [Anua vs Galderma](https://lovi.care/skincare/sg/compare/anua-vs-galderma) - [Anua vs Sesderma](https://lovi.care/skincare/sg/compare/anua-vs-sesderma) - [Medicube vs Galderma](https://lovi.care/skincare/sg/compare/medicube-vs-galderma) - [Medicube vs Sesderma](https://lovi.care/skincare/sg/compare/medicube-vs-sesderma) - [The Ordinary vs Galderma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-galderma) - [The Ordinary vs Sesderma](https://lovi.care/skincare/sg/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs Galderma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-galderma) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs Galderma](https://lovi.care/skincare/sg/compare/cosrx-vs-galderma) - [COSRX vs Sesderma](https://lovi.care/skincare/sg/compare/cosrx-vs-sesderma) - [CeraVe vs Galderma](https://lovi.care/skincare/sg/compare/cerave-vs-galderma) - [CeraVe vs Sesderma](https://lovi.care/skincare/sg/compare/cerave-vs-sesderma) - [La Roche-Posay vs Galderma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-galderma) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs Galderma](https://lovi.care/skincare/sg/compare/dr-althea-vs-galderma) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/sg/compare/dr-althea-vs-sesderma) - [Some By Mi vs Galderma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-galderma) - [Some By Mi vs Sesderma](https://lovi.care/skincare/sg/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/galderma-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/galderma-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/galderma-vs-sesderma - Germany: https://lovi.care/skincare/de/compare/galderma-vs-sesderma - France: https://lovi.care/skincare/fr/compare/galderma-vs-sesderma - Italy: https://lovi.care/skincare/it/compare/galderma-vs-sesderma - Netherlands: https://lovi.care/skincare/nl/compare/galderma-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/galderma-vs-sesderma - Canada: https://lovi.care/skincare/ca/compare/galderma-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/galderma-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/galderma-vs-sesderma (this page) - Saudi Arabia: https://lovi.care/skincare/sa/compare/galderma-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/galderma-vs-sesderma