# Clinique vs Medik8

Page: https://lovi.care/skincare/sg/compare/clinique-vs-medik8

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Clinique and Medik8 are established skincare brands known for their thoughtful ranges of moisturizers, [serums](https://lovi.care/skincare/sg/ingredients/serum), eye products, and more that incorporate key ingredients like [hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) and [glycerin](https://lovi.care/skincare/sg/ingredients/glycerin). The American brand, founded in 1968, suits dry and oily skin best by balancing moisture and controlling oil through formulations combining hyaluronic acid, glycerin, and [caffeine](https://lovi.care/skincare/sg/ingredients/caffeine). Meanwhile, the British brand, founded in 2009, builds its products around hyaluronic acid to support various complexions. They differ primarily in their heritage, ownership, and specific ingredient combinations, offering targeted solutions for acne-prone skin, dark spots, and mature skin.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Clinique) [elcompanies.com](https://www.elcompanies.com/en/who-we-are/our-heritage) [businesswire.com](https://www.businesswire.com/news/home/20261019083802/en/The-Este-Lauder-Companies-Appoints-Krista-Lee-Berger-Senior-Vice-President-Global-Marketing-Clinique) [glossy.co](https://www.glossy.co/beauty/glossy-pop-newsletter-clinique-launches-first-ever-creator-led-campaign/)

Medik8 is a British skincare brand founded in 2009 and owned by L'Oréal Groupe since 2025.

[loreal.com](https://www.loreal.com/en/press-release/group/l-oreal-groupe-to-acquire-a-majority-stake-in-medik8/) [medik8.com](https://www.medik8.com/pages/founders-story) [tracxn.com](https://tracxn.com/d/companies/medik8/__vqs3N9eL3EfvIq0IoeUPADts7CrlGbzm7kjy9M9QY8o)

This page compares some of the most popular Clinique and Medik8 products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg34823ce595).

### Popular Clinique vs Medik8 products

#### Medik8

- [Liquid Peptides](https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit
- [CRYSTAL RETINAL 3](https://lovi.care/skincare/sg/p/medik8/crystal-retinal-3/for/mature-skin) — High fit
- [C-Tetra Serum](https://lovi.care/skincare/sg/p/medik8/c-tetra-serum/for/dry-sensitive-skin) — Average fit
- [Bakuchiol Peptides](https://lovi.care/skincare/sg/p/medik8/bakuchiol-peptides/for/dry-skin) — Superior fit
- [Crystal Retinal Ceramide Eye 3](https://lovi.care/skincare/sg/p/medik8/crystal-retinal-ceramide-eye-3/for/mature-skin) — High fit
- [Oxy-R Peptides](https://lovi.care/skincare/sg/p/medik8/oxy-r-peptides/for/mature-skin) — Superior fit
- [Total Moisture Daily Facial Cream](https://lovi.care/skincare/sg/p/medik8/total-moisture-daily-facial-cream/for/mature-skin) — High fit
- [Hydr8 B5 Intense](https://lovi.care/skincare/sg/p/medik8/hydr8-b5-intense/for/dry-skin) — Superior fit

#### Clinique

- [moisture surge](https://lovi.care/skincare/sg/p/clinique/moisture-surge/for/sensitive-skin) — High fit
- [Take The Day Off Cleansing Balm](https://lovi.care/skincare/sg/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit
- [Dramatically Different Moisturizing Lotion+](https://lovi.care/skincare/sg/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin) — Average fit — [S$37.33 at YesStyle](https://www.yesstyle.com/en/clinique-dramatically-different-moisturizing-lotion-125ml/info.html/pid.1121149285?curr=SGD&rco=SG)
- [All About Eyes](https://lovi.care/skincare/sg/p/clinique/all-about-eyes/for/dry-skin) — High fit — [S$45.33 at YesStyle](https://www.yesstyle.com/en/clinique-all-about-eyes-rich-15ml/info.html/pid.1132464523?curr=SGD&rco=SG)
- [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/sg/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [S$13.55 at YesStyle](https://www.yesstyle.com/en/clinique-dramatically-different-moisturizing-gel-50ml/info.html/pid.1121149274?curr=SGD&rco=SG)
- [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit
- [Moisture Surge Overnight Mask](https://lovi.care/skincare/sg/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit
- [Clarifying Lotion 2](https://lovi.care/skincare/sg/p/clinique/clarifying-lotion-2/for/oily-acne-prone-skin) — Average fit

## People Say

Clinique

Medik8

- Sensitive skin soothing and gentle formulas Mostly Mentioned Mostly Mentioned “never irritated my eyes — Clinique All About Eyes” “No strong scent — Clinique Take The Day Off Cleansing Balm” “zero irritation or peeling — Medik8 CRYSTAL RETINAL 3” “only Vitamin C my sensitive skin can tolerate — Medik8 C-Tetra Serum”
- Plumping and smoothing effect Often Mentioned Mostly Mentioned “smoother skin — Medik8 Surface Radiance Cleanse” “My skin was smoother, my skin texture felt more resurfaced. — Medik8 Sleep Glycolic” “Reduces fine lines — Medik8 Liquid Peptides” “skin feels silky smooth — Clinique Smart Clinical Repair Wrinkle Correcting Serum”
- Lightweight and non-greasy texture Mostly Mentioned Often Mentioned “sinks in immediately — Clinique moisture surge” “sinks in instantly — Clinique Dramatically Different Moisturizing Gel” “Absorbs quickly without feeling sticky — Clinique Dramatically Different Moisturizing Lotion+” “absorbed effortlessly — Medik8 Total Moisture Daily Facial Cream”
- Hydration and moisture Often Mentioned Often Mentioned “Restores moisture — Medik8 Liquid Peptides” “Instantly quenched the skin — Medik8 Hydr8 B5 Intense” “Plumps skin with moisture — Medik8 Bakuchiol Peptides” “Keeps my dry patches at bay all day — Clinique Dramatically Different Moisturizing Lotion+”
- Radiance and brightening Rarely Noted Often Mentioned “I wake up glowing. It adds back that youthful bloom that I've lost. — Medik8 Sleep Glycolic” “unlocked a serious glow — Medik8 C-Tetra Serum” “pigmentation lightened slightly — Medik8 Oxy-R Peptides” “wake up glowing — Clinique Moisture Surge Overnight Mask”
- Makeup compatibility and base Often Mentioned Rarely Noted “Melts waterproof mascara — Clinique Take The Day Off Cleansing Balm” “foundation glides on — Clinique moisture surge” “holds concealer in place — Clinique All About Eyes” “layers well under sunscreen — Medik8 Total Moisture Daily Facial Cream”
- High price and cost concerns Often Mentioned Often Mentioned “jar is too small for the cost — Clinique moisture surge” “quite pricey — Clinique Smart Clinical Repair Wrinkle Correcting Serum” “Expensive per bottle — Medik8 Liquid Peptides” “very expensive for amount — Medik8 CRYSTAL RETINAL 3”
- Causes breakouts Sometimes Noted Rarely Noted “made me break out constantly — Medik8 C-Tetra Serum” “caused breakouts — Medik8 Oxy-R Peptides” “caused me to breakout — Medik8 Total Moisture Daily Facial Cream” “Woke up with whiteheads on my chin — Clinique Dramatically Different Moisturizing Lotion+”
- Packaging issues Rarely Noted Sometimes Noted “Unhygienic tub — Clinique Take The Day Off Cleansing Balm” “prefer a pump dispenser — Clinique All About Eyes” “pump dispenses too much — Clinique Smart Clinical Repair Wrinkle Correcting Serum” “Glass bottle breaks easily — Medik8 Liquid Peptides”

## Questions and answers

### Clinique or Medik8: which is better?

Clinique is better for lightweight and non-greasy textures as well as makeup compatibility, while Medik8 excels in providing deep hydration, plumping, radiance, and brightening benefits. Both brands share similar high price and cost concerns.

### What is the difference between Clinique and Medik8?

Clinique is known for lightweight, non-greasy textures and excellent makeup compatibility, whereas Medik8 stands out for deep hydration, plumping effects, and skin brightening. Both brands share concerns regarding a high price point.

### Clinique or Medik8: which cleanser is better?

Medik8 stands out for cleansers because Surface Radiance Cleanse achieves Superior Lovi fit levels for acne-prone skin, oily acne-prone skin, and skin with dark spots, whereas the products on this page for Clinique show lower ratings like Low for cleansers.

### Which is more affordable, Clinique or Medik8?

Both Clinique and Medik8 share a high price point as a common drawback noted by reviewers, so neither brand stands out as more affordable.

### Which causes fewer breakouts, Clinique or Medik8?

Clinique may cause fewer breakouts than Medik8 according to the review feedback on this page. Reviewers note that Clinique sometimes causes breakouts, while Medik8 has breakout issues cited as a negative review theme.

### Clinique or Medik8: which brand offers better options for sensitive skin?

Clinique and Medik8 offer equal options for sensitive skin soothing and gentle formulas. Reviewers note that both brands provide gentle care, though Clinique features fragrance-free options across all products on this page.

### Which brand has more fragrance-free products, Clinique or Medik8?

Clinique has more fragrance-free products than Medik8, as every single product on the Clinique page lists no fragrance in its ingredients, whereas Medik8 includes one fragranced product.

### Clinique or Medik8: which brand provides better results for radiance and brightening?

Medik8 provides better results for radiance and brightening according to reviewer feedback on this page. The products on this page help improve glow, while topical [vitamin C](https://lovi.care/skincare/sg/ingredients/vitamin-c) and other key ingredients are widely known to support a brighter complexion.

[Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/) [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/)

### Clinique or Medik8: which moisturizer is better?

Medik8 is generally better for moisture and plumping, offering products like Hydr8 B5 Intense which has a Superior fit for dry skin, while Clinique focuses more on lightweight and fast-absorbing formulas. [Hyaluronic acid](https://lovi.care/skincare/sg/ingredients/hyaluronic-acid) helps both brands deliver hydration.

[Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

## Research behind their key ingredients

- [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Hyaluronic acid · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Micro-acid complex · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol vitamin e, Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Protecting skin photoaging by NF-kappaB inhibitor](https://pubmed.ncbi.nlm.nih.gov/20540695/) Magnolia officinalis bark extract · Current Drug Metabolism, 2010
- [Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent](https://pubmed.ncbi.nlm.nih.gov/25648593/) Hydrolyzed opuntia ficus-indica flower extract · Molecules, 2015
- [Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica](https://pubmed.ncbi.nlm.nih.gov/25821823/) Hydrolyzed opuntia ficus-indica flower extract · BioMed Research International, 2015
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study](https://pubmed.ncbi.nlm.nih.gov/29938544/) Tetrahydrodiferuloylmethane · Drug Development and Industrial Pharmacy, 2018
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin](https://pubmed.ncbi.nlm.nih.gov/22584263/) Glyceryl glucoside · Skin Pharmacology and Physiology, 2012
- [Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/26061570/) Hydrolyzed opuntia ficus-indica flower extract · Journal of Medicinal Food, 2015
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol vitamin e, Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation](https://pubmed.ncbi.nlm.nih.gov/21946069/) Hydroxyresveratrol · Food and Chemical Toxicology, 2011
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/36350527/) Micro-acid complex · Dermatology and Therapy, 2023
- [Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy](https://pubmed.ncbi.nlm.nih.gov/36985709/) Polygonum cuspidatum root extract · Molecules, 2023
- [Role of Resveratrol in Regulating Cutaneous Functions](https://pubmed.ncbi.nlm.nih.gov/32382280/) Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB](https://pubmed.ncbi.nlm.nih.gov/17346696/) Magnolia officinalis bark extract · European Journal of Pharmacology, 2007
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide](https://pubmed.ncbi.nlm.nih.gov/22916312/) Moisturizing factors nmf, Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone, Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel extract · Phytochemistry, 2001
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results](https://pubmed.ncbi.nlm.nih.gov/39810881/) Probiotic technology · Journal of Experimental Pharmacology, 2025
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study](https://pubmed.ncbi.nlm.nih.gov/33809557/) Moisturizing factors nmf · Molecules, 2021
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane](https://pubmed.ncbi.nlm.nih.gov/22247236/) Cyclopentasiloxane · International Journal of Toxicology, 2011
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Evaluation of moisturizing and irritation potential of sacha inchi oil](https://pubmed.ncbi.nlm.nih.gov/31441999/) Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Understanding Solar Skin Elastosis-Cause and Treatment](https://pubmed.ncbi.nlm.nih.gov/30052192/) Witch hazel extract · Journal of Cosmetic Science, 2018
- [A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines](https://pubmed.ncbi.nlm.nih.gov/19874316/) Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Aloe barbadensis flower extract · Molecules, 2024
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
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- [Algae extract protection effect on oxidized protein level in human stratum corneum](https://pubmed.ncbi.nlm.nih.gov/15247018/) Algae extract · Annals of the New York Academy of Sciences, 2004
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- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
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- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate](https://pubmed.ncbi.nlm.nih.gov/21772026/) Sesamum indicum oil · International Journal of Toxicology, 2011
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
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- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
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## The brands

- American skincare: [Clinique](https://lovi.care/skincare/sg/brands/clinique)
- British skincare: [Medik8](https://lovi.care/skincare/sg/brands/medik8)

## More comparisons

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- [Anua vs Clinique](https://lovi.care/skincare/sg/compare/anua-vs-clinique)
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- [The Ordinary vs Clinique](https://lovi.care/skincare/sg/compare/the-ordinary-vs-clinique)
- [The Ordinary vs Medik8](https://lovi.care/skincare/sg/compare/the-ordinary-vs-medik8)
- [Beauty of Joseon vs Clinique](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-clinique)
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- [COSRX vs Clinique](https://lovi.care/skincare/sg/compare/cosrx-vs-clinique)
- [COSRX vs Medik8](https://lovi.care/skincare/sg/compare/cosrx-vs-medik8)
- [CeraVe vs Clinique](https://lovi.care/skincare/sg/compare/cerave-vs-clinique)
- [CeraVe vs Medik8](https://lovi.care/skincare/sg/compare/cerave-vs-medik8)
- [La Roche-Posay vs Clinique](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-clinique)
- [La Roche-Posay vs Medik8](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-medik8)
- [Dr. Althea vs Clinique](https://lovi.care/skincare/sg/compare/dr-althea-vs-clinique)
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- [Some By Mi vs Medik8](https://lovi.care/skincare/sg/compare/some-by-mi-vs-medik8)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/clinique-vs-medik8
- United Kingdom: https://lovi.care/skincare/uk/compare/clinique-vs-medik8
- Ireland: https://lovi.care/skincare/ie/compare/clinique-vs-medik8
- Germany: https://lovi.care/skincare/de/compare/clinique-vs-medik8
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- Italy: https://lovi.care/skincare/it/compare/clinique-vs-medik8
- Netherlands: https://lovi.care/skincare/nl/compare/clinique-vs-medik8
- Spain: https://lovi.care/skincare/es/compare/clinique-vs-medik8
- Canada: https://lovi.care/skincare/ca/compare/clinique-vs-medik8
- Australia: https://lovi.care/skincare/au/compare/clinique-vs-medik8
- Singapore: https://lovi.care/skincare/sg/compare/clinique-vs-medik8 (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/compare/clinique-vs-medik8
- United Arab Emirates: https://lovi.care/skincare/ae/compare/clinique-vs-medik8