Clinique vs Jole

Questions and answers

Research behind their key ingredients

• Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology

  Squalene · Molecules, 2009

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022

• Caffeine's mechanisms of action and its cosmetic use

  Caffeine · Skin Pharmacology and Physiology, 2013

• Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin

  Micro-acid complex · Journal of Dermatological Science, 2017

• Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial

  Tocopherol · Journal of Cosmetic Dermatology, 2020

• Protecting skin photoaging by NF-kappaB inhibitor

  Magnolia officinalis bark extract · Current Drug Metabolism, 2010

• Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo

  Ascorbyl glucoside · Journal of Periodontology, 2009

• Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin

  Squalane · Scientific Reports, 2020

• Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations

  Aloe barbadensis leaf water, Aloe barbadensis · Clinical Pharmacology, 2018

• Urea: a comprehensive review of the clinical literature

  Urea · Dermatology Online Journal, 2013

• Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin

  Glyceryl glucoside · Skin Pharmacology and Physiology, 2012

• Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls

  Camellia sinensis leaf extract · Experimental Dermatology, 2009

• Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris

  Micro-acid complex · Dermatology and Therapy, 2023

• Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy

  Polygonum cuspidatum root extract · Molecules, 2023

• Role of Resveratrol in Regulating Cutaneous Functions

  Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020

• Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

  Azelaic acid · Pharmaceutics, 2021

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study

  Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013

• A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

  Salicylic acid · BioMed Research International, 2020

• Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation

  Tocopheryl acetate · Urologia Internationalis, 2019

• Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB

  Magnolia officinalis bark extract · European Journal of Pharmacology, 2007

• Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide

  Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012

• The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study

  Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019

• High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin

  Witch hazel extract · Phytochemistry, 2001

• Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin

  Acetyl hexapeptide-8 · Annals of Dermatology, 2019

• Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results

  Probiotic technology · Journal of Experimental Pharmacology, 2025

• Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study

  Salicylic acid, Micro-acid complex · Journal of Cosmetic Dermatology, 2024

• Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study

  Jojoba seed oil · Forschende Komplementarmedizin, 2012

• A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide

  Salicylic acid · Journal of Drugs in Dermatology, 2023

• Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris

  Azelaic acid · Dermatology and Therapy, 2024

• Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)

  Sodium laureth sulfate · Food and Chemical Toxicology, 2001

• Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model

  Jojoba seed oil · Frontiers in Pharmacology, 2024

• Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane

  Cyclopentasiloxane · International Journal of Toxicology, 2011

• The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study

  Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017

• Whitening effect of alpha-bisabolol in Asian women subjects

  Bisabolol · International Journal of Cosmetic Science, 2010

• Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract

  Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019

• The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study

  Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023

• The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging

  Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023

• Understanding Solar Skin Elastosis-Cause and Treatment

  Witch hazel extract · Journal of Cosmetic Science, 2018

• Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast

  Squalane · Molecules, 2025

• Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota

  Camellia sinensis leaf extract · Molecules, 2024

• Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis

  Yeast extract · Journal of Clinical Medicine, 2023

• Influence of vitamin E acetate on stratum corneum hydration

  Tocopheryl acetate · Arzneimittel-Forschung, 1998

• Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles

  Dimethoxytolyl propylresorcinol · Journal of Cosmetic Dermatology, 2021

• Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits

  Multi-peptides · Journal of Cosmetic Dermatology, 2010

• Algae extract protection effect on oxidized protein level in human stratum corneum

  Algae extract · Annals of the New York Academy of Sciences, 2004

• Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects

  Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024

• Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate

  Sesamum indicum oil · International Journal of Toxicology, 2011

• The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects

  Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013

• Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol

  Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009

• Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

  Caprylic capric triglyceride, Capric triglyceride · Life, 2023

• Functional properties and skin care effects of sodium trehalose sulfate

  Trehalose · Skin Research and Technology, 2024

• A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females

  Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016

• Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy

  Tocopheryl acetate · Scientific Reports, 2025

• Evaulation of irritation potential of surfactant mixtures

  Sodium laureth sulfate · International Journal of Cosmetic Science, 1999

• Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome

  Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023

• Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial

  Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021

• The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study

  Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

• Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging

  Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025

• Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos

  Ascorbyl glucoside · International Journal of Molecular Sciences, 2024

• Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers

  Dimethicone · Military Medicine, 2024

• The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies

  Laminaria digitata extract · International Journal of Cosmetic Science, 2026

• Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial

  Butyrospermum parkii butter shea butter, Shea butter · Lasers in Medical Science, 2025

• Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial

  Ascorbyl glucoside · Cureus, 2026

• Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study

  Sodium laureth sulfate · International Journal of Pharmaceutics, 2026

• Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients

  Lactobacillus ferment · International Journal of Cosmetic Science, 2026

• Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial

  Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.