# Cetaphil vs Trilogy

Page: https://lovi.care/skincare/sg/compare/cetaphil-vs-trilogy

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Singapore.

Cetaphil and Trilogy are two celebrated skincare brands offering distinct approaches to daily wellness. Cetaphil is an American brand founded in 1947 and owned by Galderma Group AG, widely loved for its thoughtful range of cleansers, moisturizers, [serums](https://lovi.care/skincare/sg/ingredients/serum), sunscreens, and more, which are carefully formulated with nourishing ingredients like [glycerin](https://lovi.care/skincare/sg/ingredients/glycerin), [niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide), and [panthenol](https://lovi.care/skincare/sg/ingredients/panthenol). Meanwhile, Trilogy is deeply loved for its thoughtful moisturizers and gentle cleansers, built on high-performing formulas. The former brand suits combination skin and acne-prone skin best, while the latter brand suits dry, balanced, and sensitive skin types best, differing through their specific ingredient compositions and targeted product offerings.

Cetaphil is an American skincare brand founded in 1947 and owned by Galderma Group AG.

[en.wikipedia.org](https://en.wikipedia.org/wiki/Cetaphil) [cetaphil.co.uk](https://www.cetaphil.co.uk/why-cetaphil/our-story.html)

This page compares some of the most popular Cetaphil and Trilogy products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgabd74e8ab7).

### Popular Cetaphil vs Trilogy products

#### Cetaphil

- [Gentle Skin Cleanser](https://lovi.care/skincare/sg/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [S$29.66 at Amazon](https://www.amazon.sg/dp/B099N3NM61?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Moisturizing Cream](https://lovi.care/skincare/sg/p/cetaphil/moisturizing-cream/for/dry-skin) — Average fit — [S$31.81 at Amazon](https://www.amazon.sg/dp/B099N1LC4R?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Daily Facial Cleanser](https://lovi.care/skincare/sg/p/cetaphil/daily-facial-cleanser/for/oily-skin) — Superior fit — [S$26.29 at Amazon](https://www.amazon.sg/dp/B099MSZX25?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Moisturizing Lotion](https://lovi.care/skincare/sg/p/cetaphil/moisturizing-lotion/for/sensitive-skin) — Average fit — [S$29.98 at Amazon](https://www.amazon.sg/dp/B099N2SLT9?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Gentle Exfoliating SA Cleanser](https://lovi.care/skincare/sg/p/cetaphil/gentle-exfoliating-sa-cleanser/for/acne-prone-skin) — High fit
- [Moisturising Cream](https://lovi.care/skincare/sg/p/cetaphil/moisturising-cream/for/dry-sensitive-skin) — Average fit
- [Gentle Cleansing Bar](https://lovi.care/skincare/sg/p/cetaphil/gentle-cleansing-bar/for/dry-skin) — High fit — [S$26.50 at Amazon](https://www.amazon.sg/dp/B004OCGZWW?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)
- [Extra Gentle Daily Scrub](https://lovi.care/skincare/sg/p/cetaphil/extra-gentle-daily-scrub/for/sensitive-skin) — Superior fit — [S$31.19 at Amazon](https://www.amazon.sg/dp/B077FZ112C?tag=lovi-care-web-product0e-22&linkCode=osi&th=1&psc=1)

#### Trilogy

- [Rosehip Cream Cleanser](https://lovi.care/skincare/sg/p/trilogy/rosehip-cream-cleanser/for/sensitive-skin) — High fit
- [Line Smoothing Day Cream](https://lovi.care/skincare/sg/p/trilogy/line-smoothing-day-cream/for/dry-skin) — High fit
- [Vitamin C Ceramide Night Cream](https://lovi.care/skincare/sg/p/trilogy/vitamin-c-ceramide-night-cream/for/mature-skin) — High fit

## People Say

Cetaphil

Trilogy

- Hydration and moisture Mostly Mentioned Mostly Mentioned “Keeps skin moisturized — Trilogy Vitamin C Ceramide Night Cream” “Leaves skin thoroughly moisturised — Trilogy Line Smoothing Day Cream” “Feels moisturizing — Trilogy Rosehip Cream Cleanser” “cleared up flaky skin — Cetaphil Moisturizing Cream”
- Gentle on sensitive skin Mostly Mentioned Mostly Mentioned “The only thing my reactive skin tolerates. — Cetaphil Gentle Skin Cleanser” “No breakouts since switching to this. — Cetaphil Gentle Skin Cleanser” “cleans without stripping — Cetaphil Daily Facial Cleanser” “Doesn't irritate my sensitive skin — Trilogy Rosehip Cream Cleanser”
- Smoother skin and complexion Sometimes Noted Mostly Mentioned “Wake to a glowing complexion — Trilogy Vitamin C Ceramide Night Cream” “Noticeable difference — Trilogy Line Smoothing Day Cream” “Skin felt softer after one use — Cetaphil Gentle Exfoliating SA Cleanser”
- Lightweight and non-greasy absorption Often Mentioned Often Mentioned “absorbs instantly — Cetaphil Moisturizing Lotion” “Absorbs quickly into skin without residue — Cetaphil Daily Hydrating Lotion” “absorbs quickly — Cetaphil Moisturizing Cream” “Not greasy — Trilogy Line Smoothing Day Cream”
- Rich and creamy texture Not noted Mostly Mentioned “Silky cream consistency — Trilogy Rosehip Cream Cleanser” “Luxuriously rich — Trilogy Vitamin C Ceramide Night Cream”
- Fragrance-free and scent characteristics Sometimes Noted Sometimes Noted “truly no smell — Cetaphil Moisturizing Lotion” “Love that it has no scent. — Cetaphil Gentle Skin Cleanser” “Gorgeous smelling — Trilogy Rosehip Cream Cleanser”
- Poor makeup removal Sometimes Noted Sometimes Noted “Doesn't take off mascara at all. — Cetaphil Gentle Skin Cleanser” “doesn't remove mascara — Cetaphil Daily Facial Cleanser” “Not effective for heavy makeup — Trilogy Rosehip Cream Cleanser”
- Packaging and pricing inconveniences Sometimes Noted Sometimes Noted “hate dipping fingers in — Cetaphil Moisturising Cream” “wish it had a pump — Cetaphil Moisturizing Cream” “Price to be high relative to performance — Trilogy Rosehip Cream Cleanser” “Big to pop in my handbag — Trilogy Line Smoothing Day Cream”

## Questions and answers

### Cetaphil or Trilogy: which is better?

Cetaphil is better for being gentle on sensitive skin and providing lightweight, non-greasy absorption across the products on this page, whereas Trilogy performs better for hydration, moisture, and richer texture. [Niacinamide](https://lovi.care/skincare/sg/ingredients/niacinamide) helps reduce cutaneous pigmentation.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What is the difference between Cetaphil and Trilogy?

Cetaphil is better for sensitive skin with lightweight absorption, whereas Trilogy excels in hydration, moisture, and rich textures. Reviewers note that Cetaphil offers gentle, non-stripping cleansers while Trilogy products provide brightening moisturizers.

### Cetaphil or Trilogy: which cleanser is better?

Cetaphil offers a much wider variety of cleansers on this page that rate High or Superior for skin types like sensitive, oily, and acne-prone skin, whereas Trilogy features only a single cream cleanser. Reviewers note that Cetaphil cleansers are generally gentle and non-stripping.

### Which is more affordable, Cetaphil or Trilogy?

The products on this page do not provide pricing information to determine whether Cetaphil or Trilogy is more affordable.

### Which causes fewer breakouts, Cetaphil or Trilogy?

Cetaphil is a better fit for acne-prone skin, as the products on this page achieve High to Superior Lovi fit levels for acne-prone skin across many cleansers, scrubs, and [serums](https://lovi.care/skincare/sg/ingredients/serum), whereas Trilogy does not list acne-prone skin among its best-fit skin types and shows average fits for its products.

### Between Cetaphil and Trilogy, which brand is better for hydration and moisture?

Trilogy is better for hydration and moisture among the products on this page. Reviewers report that Trilogy offers superior hydration and moisture compared to Cetaphil.

### How does the fragrance content compare between Cetaphil and Trilogy products?

Cetaphil products on this page are mostly fragrance-free with only one listing a scent, whereas Trilogy products on this page frequently include fragrance.

### Which brand was founded earlier and in what country?

Cetaphil was founded earlier in 1947 in the United States, whereas Trilogy was founded in 2002.

### Cetaphil or Trilogy: which moisturizer is better?

When comparing moisturizers, Cetaphil provides better options for lightweight and non-greasy absorption, while Trilogy is rated higher for hydration and moisture across the products on this page.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide, Gentlebright complex · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, Panthenol vitamin b5 · American Journal of Clinical Dermatology, 2002
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Sodium ascorbyl phosphate ascorbic acid, Ascorbyl palmitate ascorbic acid · Experimental Dermatology, 2003
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Effects of menthol and cold on histamine-induced itch and skin reactions in man](https://pubmed.ncbi.nlm.nih.gov/7624016/) Peppermint leaf extract · Neuroscience Letters, 1995
- [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Sodium ascorbyl phosphate ascorbic acid · Journal of Periodontology, 2009
- [Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter](https://pubmed.ncbi.nlm.nih.gov/18503414/) Titanium dioxide · International Journal of Cosmetic Science, 2000
- [The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction](https://pubmed.ncbi.nlm.nih.gov/27475700/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study](https://pubmed.ncbi.nlm.nih.gov/33966113/) Ascorbic acid · Clinical Oral Investigations, 2021
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin](https://pubmed.ncbi.nlm.nih.gov/27349297/) Xylitol, Xylitylglucoside · Acta Dermato-venereologica, 2017
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin](https://pubmed.ncbi.nlm.nih.gov/25607907/) Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2015
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide, Gentlebright complex · Journal of Cosmetic Dermatology, 2021
- [Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin](https://pubmed.ncbi.nlm.nih.gov/32657437/) Gentlebright complex · International Journal of Cosmetic Science, 2020
- [The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide](https://pubmed.ncbi.nlm.nih.gov/11509913/) Titanium dioxide · Skin Pharmacology and Applied Skin Physiology, 2001
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum extract · Genes, 2020
- [Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study](https://pubmed.ncbi.nlm.nih.gov/34877760/) Sodium ascorbyl phosphate ascorbic acid · Dermatologic Therapy, 2022
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, Panthenol vitamin b5 · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate vitamin e, Tocopheryl acetate vitamin e acetate · Urologia Internationalis, 2019
- [Ascorbic Acid Treatments as Effective and Safe Anti-Aging Therapies for Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/38397772/) Ascorbyl palmitate ascorbic acid · Antioxidants, 2024
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant](https://pubmed.ncbi.nlm.nih.gov/31130869/) Caffeine · Frontiers in Physiology, 2019
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011
- [A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties](https://pubmed.ncbi.nlm.nih.gov/35200634/) Dunaliella salina extract · Marine Drugs, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Panthenol vitamin b5, Panthenol, Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Pha polyhydroxy acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract](https://pubmed.ncbi.nlm.nih.gov/32812663/) Rice extract lees extract · International Journal of Cosmetic Science, 2020
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Pha polyhydroxy acid · The Australasian Journal of Dermatology, 1992
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment](https://pubmed.ncbi.nlm.nih.gov/19134126/) Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity](https://pubmed.ncbi.nlm.nih.gov/27272074/) Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L](https://pubmed.ncbi.nlm.nih.gov/34065623/) Avena sativa kernel extract oat kernel extract · Pharmaceutics, 2021
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Citric acid · Journal of Cosmetic Dermatology, 2021
- [Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers](https://pubmed.ncbi.nlm.nih.gov/27756097/) Sodium ascorbyl phosphate · Drug Research, 2017
- [The impacts of sodium lauroyl sarcosinate in facial cleanser on facial skin microbiome and lipidome](https://pubmed.ncbi.nlm.nih.gov/37990616/) Sodium lauroyl sarcosinate · Journal of Cosmetic Dermatology, 2024
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate vitamin e, Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid](https://pubmed.ncbi.nlm.nih.gov/20367666/) Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021
- [Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers](https://pubmed.ncbi.nlm.nih.gov/32383548/) Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021
- [Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/41142247/) Ascorbyl palmitate ascorbic acid · Frontiers in Pharmacology, 2025
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Modulation of lipid fluidity likely contributes to the fructose/xylitol-induced acceleration of epidermal permeability barrier recovery](https://pubmed.ncbi.nlm.nih.gov/30847563/) Xylitylglucoside · Archives of Dermatological Research, 2019
- [Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study](https://pubmed.ncbi.nlm.nih.gov/32379165/) Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, Panthenol vitamin b5 · Journal of Cosmetic Dermatology, 2025
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects](https://pubmed.ncbi.nlm.nih.gov/22142309/) Sodium ascorbyl phosphate · Experimental Dermatology, 2012
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate · Journal of Cosmetic Dermatology, 2013
- [Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model](https://pubmed.ncbi.nlm.nih.gov/11867969/) Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Xylitylglucoside · Molecules, 2021
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate vitamin e, Tocopheryl acetate vitamin e acetate, Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e, Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Octocrylene · Archives of Dermatological Research, 2024
- [A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen](https://pubmed.ncbi.nlm.nih.gov/15002657/) Pha polyhydroxy acid · Cutis, 2004
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration](https://pubmed.ncbi.nlm.nih.gov/41129958/) Sodium pca · Biomaterials Advances, 2026
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025
- [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) Ceramide iii · Skin Pharmacology and Physiology, 2026

## The brands

- American skincare: [Cetaphil](https://lovi.care/skincare/sg/brands/cetaphil)
- Skincare: [Trilogy](https://lovi.care/skincare/sg/brands/trilogy)

## More comparisons

- [SKIN1004 vs Cetaphil](https://lovi.care/skincare/sg/compare/skin1004-vs-cetaphil)
- [SKIN1004 vs Trilogy](https://lovi.care/skincare/sg/compare/skin1004-vs-trilogy)
- [Anua vs Cetaphil](https://lovi.care/skincare/sg/compare/anua-vs-cetaphil)
- [Anua vs Trilogy](https://lovi.care/skincare/sg/compare/anua-vs-trilogy)
- [Medicube vs Cetaphil](https://lovi.care/skincare/sg/compare/medicube-vs-cetaphil)
- [Medicube vs Trilogy](https://lovi.care/skincare/sg/compare/medicube-vs-trilogy)
- [The Ordinary vs Cetaphil](https://lovi.care/skincare/sg/compare/the-ordinary-vs-cetaphil)
- [The Ordinary vs Trilogy](https://lovi.care/skincare/sg/compare/the-ordinary-vs-trilogy)
- [Beauty of Joseon vs Cetaphil](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-cetaphil)
- [Beauty of Joseon vs Trilogy](https://lovi.care/skincare/sg/compare/beauty-of-joseon-vs-trilogy)
- [COSRX vs Cetaphil](https://lovi.care/skincare/sg/compare/cosrx-vs-cetaphil)
- [COSRX vs Trilogy](https://lovi.care/skincare/sg/compare/cosrx-vs-trilogy)
- [CeraVe vs Cetaphil](https://lovi.care/skincare/sg/compare/cerave-vs-cetaphil)
- [CeraVe vs Trilogy](https://lovi.care/skincare/sg/compare/cerave-vs-trilogy)
- [La Roche-Posay vs Cetaphil](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-cetaphil)
- [La Roche-Posay vs Trilogy](https://lovi.care/skincare/sg/compare/la-roche-posay-vs-trilogy)
- [Dr. Althea vs Cetaphil](https://lovi.care/skincare/sg/compare/dr-althea-vs-cetaphil)
- [Dr. Althea vs Trilogy](https://lovi.care/skincare/sg/compare/dr-althea-vs-trilogy)
- [Some By Mi vs Cetaphil](https://lovi.care/skincare/sg/compare/some-by-mi-vs-cetaphil)
- [Some By Mi vs Trilogy](https://lovi.care/skincare/sg/compare/some-by-mi-vs-trilogy)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/cetaphil-vs-trilogy
- United Kingdom: https://lovi.care/skincare/uk/compare/cetaphil-vs-trilogy
- Ireland: https://lovi.care/skincare/ie/compare/cetaphil-vs-trilogy
- Germany: https://lovi.care/skincare/de/compare/cetaphil-vs-trilogy
- France: https://lovi.care/skincare/fr/compare/cetaphil-vs-trilogy
- Italy: https://lovi.care/skincare/it/compare/cetaphil-vs-trilogy
- Netherlands: https://lovi.care/skincare/nl/compare/cetaphil-vs-trilogy
- Spain: https://lovi.care/skincare/es/compare/cetaphil-vs-trilogy
- Canada: https://lovi.care/skincare/ca/compare/cetaphil-vs-trilogy
- Australia: https://lovi.care/skincare/au/compare/cetaphil-vs-trilogy
- Singapore: https://lovi.care/skincare/sg/compare/cetaphil-vs-trilogy (this page)
- Saudi Arabia: https://lovi.care/skincare/sa/compare/cetaphil-vs-trilogy
- United Arab Emirates: https://lovi.care/skincare/ae/compare/cetaphil-vs-trilogy