# ZO Skin Health Daily Power Defense for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [ZO Skin Health](https://lovi.care/skincare/sa/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your redness and irritation, as Glycerin and Beta-Glucan provide hydration and soothing effects suitable for normal, sensitive skin.
- Arabidopsis Thaliana Extract and Marrubium Vulgare Meristem Cell Culture offer excellent protection against environmental stressors, complementing the product's overall supportive actions.
- The product is safe for your sensitive skin, containing no harsh ingredients and including soothing agents like Laminaria Digitata Extract and Beta-Glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Beta-Glucan, Arabidopsis Thaliana Extract, Tocopheryl Acetate, Palmitoyl Tripeptide-1

## What the research says

- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of photolyase-containing liposomes followed by photoreactivating light decreased UVB-induced dimers by 40-45% and prevented immunosuppression, erythema, and sunburn-cell formation in healthy human subjects. ([Proceedings of the National Academy of Sciences of the United States of America, 2000](https://pubmed.ncbi.nlm.nih.gov/10660687/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on limited data, this serum is highly regarded for its ability to repair the skin barrier, providing a healthy glow and improved texture. Most users appreciate its lightweight feel and hydrating properties. Some users report experiencing initial irritation or breakouts due to active ingredients, and the high price point is a frequent concern.

- Liked: Barrier repair (mostly mentioned)
- Liked: Lightweight & absorbent (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Anti-aging results (sometimes noted)
- Liked: Versatile hydration (sometimes noted)
- Disliked: Initial irritation (sometimes noted)
- Disliked: Counterfeit risk (rarely noted)
- Disliked: Scent/packaging (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Daily Power Defense work for sensitive skin?

This treatment works moderately well for sensitive skin, offering soothing hydration and protection from everyday stress. It is safe and unlikely to cause irritation, though other products fit this skin type better. Sensitive skin of this type needs products with gentle, highly compatible ingredients that target redness while providing robust hydration and repair without harsh additives.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for sensitive skin?

Glycerin and beta-glucan help make this serum a good fit for sensitive skin by providing gentle hydration and calming redness. A treatment of this type also needs soothing and hydrating ingredients along with potent antioxidants and skin-repairing components to properly care for sensitive skin.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does Beta-Glucan do for sensitive skin?

Beta-glucan helps calm sensitive and irritated skin by soothing discomfort and supporting the skin barrier. It is unlikely to cause irritation and may improve overall skin recovery and moisture.
Sources: [International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/), [Phytotherapy Research, 2014](https://pubmed.ncbi.nlm.nih.gov/23494974/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure. Because this is an average fit for sensitive skin, a product of this type needs calming plant extracts and hydrating ingredients like glycerin to keep redness low.

### Can I use it with vitamin C, and in what order?

You can use this treatment with vitamin C by applying vitamin C in the morning and saving this product for your evening routine. This helps keep sensitive skin calm while avoiding irritation from layering multiple active ingredients at the same time. Sensitive skin types typically do better with products that rely on gentle hydrators like glycerin and beta-glucan alongside calming plant extracts.

### How often should I use this serum?

This treatment is applied in the evening. To fit sensitive skin better, this product needs calming and hydrating ingredients like glycerin, beta-glucan, and soothing plant extracts.
Sources: [Proceedings of the National Academy of Sciences of the United States of America, 2000](https://pubmed.ncbi.nlm.nih.gov/10660687/)

### Can it clog pores, cause breakouts or purging for sensitive skin?

This treatment may cause initial irritation on sensitive skin, but it is unlikely to clog pores. To work well for sensitive skin, a product of this type needs calming ingredients like beta-glucan and hydrating agents like glycerin to keep redness and dryness at bay without heavy oils.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum and limonene). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — SAR 461.00 at Amazon
- [Clarins Double Serum](https://lovi.care/skincare/sa/p/clarins/double-serum/for/sensitive-skin) — High fit — SAR 399.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — SAR 865.37 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — SAR 191.00 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/sa/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — SAR 141.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/sa/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — SAR 132.22 at Amazon

## Where to buy

- Amazon.sa: SAR 662.61 (https://www.amazon.sa/dp/B07QF1B66M?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, 1,2-Hexanediol, Dicaprylyl Carbonate, Cetearyl Isononanoate, Glycerin, Pentylene Glycol, Cetearyl Alcohol, Steareth-20, Safflower Palm Aminopropanediol Esters Oil, Laminaria Digitata Extract, Opuntia Ficus-Indica Stem Extract, Arabidopsis Thaliana Extract, Marrubium Vulgare Meristem Cell Culture, Leontopodium Alpinum Meristem Cell Culture, Retinyl Palmitate, Tocopheryl Acetate, Tocopherol, Micrococcus Lysate, Caprylyl Glycol, Hexylene Glycol, Lactose, Galactoarabinan, Schizophyllan, Beta-Glucan, Carbomer, Cellulose, Maltodextrin, C14-22 Alcohols, C12-20 Alkyl Glucoside, Hydroxypropyl Methylcellulose, Disodium Edta, Sodium Hydroxide, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Parfum, Ultramarines, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/daily-power-defense/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/daily-power-defense/for/sensitive-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/daily-power-defense/for/sensitive-skin