# Theramid DERMA-PEPTIDES for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Theramid](https://lovi.care/skincare/sa/brands/theramid)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other moisturizers fit it better.

## Why this fit

- Suitable for normal skin, this product utilizes Palmitoyl Tripeptide-1 and Sh-Oligopeptide-1 to support collagen stimulation and extracellular matrix synthesis, which is beneficial for overall skin health.
- Glycerin and Propanediol offer moderate moisturizing benefits, but these ingredients do not directly address your main goal of pigmentation.
- The product is safe for your normal skin, as it lacks prohibited or harsh ingredients and poses no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/oily-acne-prone-skin): Low

## Key ingredients

Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, Palmitoyl Tetrapeptide-7

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))

## What reviewers say

Users frequently praise this serum for its lightweight, non-sticky texture and its effectiveness in delivering visible anti-aging results, such as increased skin plumpness and reduced fine lines. It is also noted for its gentle, fragrance-free formulation, making it suitable for sensitive skin and compatible with other active ingredients.

- Liked: Visible anti-aging (mostly mentioned)
- Liked: Gentle formulation (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Good value (sometimes noted)
- Liked: Practical packaging (sometimes noted)
- Disliked: High expectations (rarely noted)
- Disliked: Limited availability (rarely noted)
- Disliked: Packaging preference (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Theramid Derma-Peptides work for skin with dark spots?

Theramid Derma-Peptides works for skin with dark spots only moderately well, because its peptides support collagen and overall skin health while glycerin and propanediol provide moderate moisture rather than directly fading dark spots. A product of this type needs hydrating and soothing ingredients that safely address pigmentation concerns while maintaining the skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### Which ingredients make this treatment a good fit for skin with dark spots?

Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, and Palmitoyl Tetrapeptide-7 are unlikely to directly fade dark spots, though they support overall skin health. A treatment for this skin needs ingredients that safely address pigmentation concerns with hydrating and soothing benefits.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### What does Palmitoyl Tripeptide-1 do for skin with dark spots?

Palmitoyl tripeptide-1 helps improve skin firmness and targets signs of aging, but it is primarily paired with other ingredients like baicalin for daytime luminance rather than fading dark spots directly.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/)

### What does EGF do for skin with dark spots?

Epidermal growth factor may help fade dark spots on some skin types, but results vary depending on the treatment and individual skin response. While some studies show it can help reduce dark spots and prevent discoloration after procedures, other research finds no significant difference compared to standard care.
Sources: [Dermatologic Surgery, 2015](https://pubmed.ncbi.nlm.nih.gov/25551327/), [Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/)

### Where does this treatment go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine before your moisturizer for simplicity and extra safety around sun exposure. It helps support overall skin health and provides moderate moisture, though fading dark spots requires a product that specifically targets pigmentation with brightening ingredients.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol, applying the treatment first and following with retinol, or using this treatment in the morning and retinol at night. It is safe for your skin and poses no risk of irritation, though skin with dark spots needs dedicated brightening ingredients to effectively target pigmentation.

### How often should I use this treatment?

Apply this treatment in the evening as part of your nighttime routine. This helps keep things simple and avoids extra safety concerns around sun exposure.

### Can this treatment clog pores, cause breakouts or purging for skin with dark spots?

This treatment is unlikely to clog pores or cause breakouts for skin with dark spots, as it lacks harsh ingredients and poses no risk of irritation. A product of this type for skin with dark spots needs targeted brightening ingredients that directly address pigmentation alongside its moisturizing benefits.

### Can I use this treatment around the eyes or on my body?

Yes, you can use this moisturizing treatment around your eyes and on your body because its gentle formula is safe and unlikely to cause irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

## Alternatives for skin with dark spots

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/sa/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dark-spots) — High fit — SAR 69.70 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/sa/p/missha/super-aqua-ultra-hyalron-ampoule/for/dark-spots) — Average fit — SAR 70.40 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/sa/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — SAR 81.67 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sa/p/isdin/eryfotona-actinica-spf-50/for/dark-spots) — Superior fit — SAR 429.81 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Propanediol, Caprylic Capric Triglyceride, Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, Palmitoyl Tetrapeptide-7
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/theramid/derma-peptides/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/theramid/derma-peptides/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/theramid/derma-peptides/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/theramid/derma-peptides/for/dark-spots
- France: https://lovi.care/skincare/fr/p/theramid/derma-peptides/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/theramid/derma-peptides/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/theramid/derma-peptides/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/theramid/derma-peptides/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/theramid/derma-peptides/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/theramid/derma-peptides/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/theramid/derma-peptides/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/dark-spots (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/theramid/derma-peptides/for/dark-spots