# The Ordinary Argireline Solution 10% for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [The Ordinary](https://lovi.care/skincare/sa/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Suitable for normal skin, this formula utilizes Acetyl Hexapeptide-8 to support collagen stimulation and extracellular matrix synthesis, offering moderate plumping effects for wrinkles and fine lines.
- Propanediol acts as a humectant, providing hydration that complements the peptide's action for smoother-looking skin.
- The product is safe for your skin, as it contains soothing ingredients and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin): Average

## Key ingredients

Acetyl Hexapeptide-8, Propanediol, Gellan Gum, Phenoxyethanol, Sodium Chloride

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))
- Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33130262/))
- Oleuropein-rich gellan gum and sodium alginate hydrogel films acted as effective antioxidant and photoprotectant treatments against UVA-induced photoaging in normal human dermal fibroblasts. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37298828/))
- Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels scavenged 88.5% of free radicals, reduced transepidermal water loss by up to 33.3%, and improved moisture content and skin structural characteristics in a murine dry skin model. ([International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41224059/))
- Calcium hydroxylapatite diluted with normal saline combined with microfocused ultrasound with visualization improved age-related changes in the lower face, neck, and décolleté and stimulated collagen and elastin fibers in 20 subjects. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32272518/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of magnetized saline water serum improved skin hydration, reduced transepidermal water loss, sebum content, melanin index, and erythema index, and activated autophagy by increasing Beclin-1 and decreasing mTOR in females wanting to enhance facial and neck skin appearance. ([Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38130575/))

## What reviewers say

Based on a very large amount of data, users frequently describe this serum as "Botox in a bottle," praising its ability to soften dynamic facial lines, particularly on the forehead and around the eyes. While many with mature or expressive skin report smoother texture and reduced wrinkle depth with consistent use, a notable portion of users saw no visible difference, suggesting efficacy varies significantly by skin type and depth of lines.

- Liked: Softens dynamic lines (mostly mentioned)
- Liked: Affordable price point (often mentioned)
- Liked: Lightweight watery texture (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Too runny/watery (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Results take time (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Argireline Solution work for mature skin?

This treatment works for mature skin, though other products fit it better because they offer higher safety with zero risk of irritation, highly potent antioxidants, skin-repairing ingredients, and exceptional effectiveness against fine lines and wrinkles. Acetyl Hexapeptide-8 and hydrating components help smooth the skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Which ingredients make this serum a good fit for mature skin?

Acetyl Hexapeptide-8 and propanediol make this serum a good fit for mature skin by supporting collagen production, providing hydration, and helping smooth out fine lines and wrinkles. Mature skin of this type needs products packed with potent antioxidants, hydrating components, skin-repairing ingredients, and peptides to improve elasticity and moisture retention.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### What does Argireline do for mature skin?

Argireline helps smooth out lines and makes mature skin look firmer and less rough when used twice a day. It may also help keep skin hydrated, though its penetration is naturally limited.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Propanediol do for mature skin?

Propanediol helps mature skin by increasing moisture and keeping it hydrated throughout the day. It also works well with other moisturizing ingredients like glycerol to support the skin barrier and maintain a soft, smooth feel.
Sources: [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/), [Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. To get the best results for mature skin, a product of this type needs peptides that support collagen and hydration-boosting ingredients to help smooth out fine lines.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment after cleansing and before your moisturizer. Mature skin needs products with peptides like Acetyl Hexapeptide-8 and hydrating ingredients like Propanediol to smooth fine lines and plump wrinkles.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is safe for your skin and helps smooth fine lines, though mature skin works best with products that offer deeper collagen support and stronger firming benefits.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it has a lightweight, water-based feel and lacks heavy oils or harsh ingredients. Mature skin needing better anti-wrinkle results often benefits from richer formulas that combine peptides with deeply nourishing hydrators and barrier-supporting ingredients.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — SAR 865.37 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/sa/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — SAR 5,271.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin, Ethoxydiglycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/argireline-solution-10/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/argireline-solution-10/for/mature-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/argireline-solution-10/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/argireline-solution-10/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/argireline-solution-10/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/argireline-solution-10/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/argireline-solution-10/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/argireline-solution-10/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/argireline-solution-10/for/mature-skin