# The First Geniture Cell Essential Source for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: The First Geniture
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration for your normal skin, as Glycerin and Hydrolyzed Hyaluronic Acid provide humectant benefits to plump and moisturize. Panthenol and Dipotassium Glycyrrhizate offer supportive soothing effects for your redness and irritation.
- The formulation includes a variety of fermented extracts and peptides that contribute to overall skin health and barrier support.
- The product is safe for your sensitive skin, containing no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/oily-acne-prone-skin): Superior

## Key ingredients

Paeonia Suffruticosa Branch Leaf Extract Flower, Hydrolyzed Hyaluronic Acid, Niacinamide, Glycerin, Oligopeptide-1

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Self-assembled cubic liquid crystalline nanoparticles loaded with paeonol reduced skin irritation compared to commercial ointment, serving as a promising transdermal delivery system. ([Medical Science Monitor, 2015](https://pubmed.ncbi.nlm.nih.gov/26517086/))
- Partially purified paeoniflorin protected human keratinocytes and mouse skin from UV-induced DNA damage and reduced facial wrinkles in human volunteers. ([Journal of Cosmetic Science, 2006](https://pubmed.ncbi.nlm.nih.gov/16676123/))
- Paeonia suffruticosa callus extract downregulated inflammatory factors, alleviated DNA damage, and increased total collagen content in in vitro and in vivo evaluations. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40079176/))
- Topical application of Paeonia lactiflora root extract and paeoniflorin significantly decreases melanin content by 23% to 30% in reconstructed pigmented human epidermis compared to vehicle control. ([International Journal of Cosmetic Science, 2016](https://pubmed.ncbi.nlm.nih.gov/26826350/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))

## What reviewers say

Based on limited data, users describe this product as a holy grail first-step essence that resolves inner dryness and improves skin texture without feeling heavy. It is praised for its water-like absorption and deep hydration, making it suitable for dehydrated or combination skin types that need moisture without stickiness. The high price point is a frequent concern, and some users find the application messy or note potential irritation from the fragrance or ingredients. Availability can also be an issue.

- Liked: Superior absorption (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Layering capability (sometimes noted)
- Disliked: Messy application (sometimes noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Fragrance/irritation (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does The First Geniture Cell Essential Source work for sensitive skin?

The First Geniture Cell Essential Source works for sensitive skin, though other products fit it better because they offer stronger hydration and soothing benefits. To care for sensitive skin, a moisturizing treatment needs gentle ingredients like hyaluronic acid and panthenol to calm redness and lock in moisture without causing irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this moisturizing treatment a good fit for sensitive skin?

This moisturizing treatment is a good fit for sensitive skin because it contains glycerin and hydrolyzed hyaluronic acid to plump and moisturize, along with panthenol and dipotassium glycyrrhizate to soothe redness and irritation. To fit sensitive skin even better, a moisturizing treatment of this type needs highly suitable, allergen-free ingredients that deliver maximum hydration and strengthen the skin barrier without any risk of irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Paeonia Suffruticosa Branch Leaf Extract do for sensitive skin?

Paeonia Suffruticosa Branch Leaf Extract helps calm sensitive and irritated skin by reducing redness and soothing inflammation. It supports skin comfort and may protect against everyday stress, though an individual's reaction can vary.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40079176/), [Phytomedicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38579646/)

### What does Hydrolyzed Hyaluronic Acid do for sensitive skin?

Hydrolyzed hyaluronic acid helps hydrate and calm sensitive skin while improving skin texture. It is unlikely to cause irritation due to its very good safety profile.
Sources: [Archives of Dermatological Research, 2024](https://pubmed.ncbi.nlm.nih.gov/38829483/), [Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/)

### Where does it go in a skincare routine for sensitive skin?

This moisturizing treatment goes in the evening routine after cleansing and toning. Sensitive skin needs a product of this type to include calming and hydrating ingredients like glycerin, hyaluronic acid, and panthenol to keep the skin soft and comfortable.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this moisturizing treatment with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it before your retinol to help soothe and hydrate your skin. This product of this type needs calming ingredients like panthenol or soothing plant extracts to keep sensitive skin comfortable while using strong actives.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### How often should I use it?

You can use this treatment in your evening routine, applying it after your toner and before your moisturizer. Daily application helps improve skin moisture and keeps your sensitive skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this moisturizing treatment clog pores, cause breakouts or purging for sensitive skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for sensitive skin because it contains no heavy oils or harsh ingredients. An average fit for sensitive skin means a product of this type needs soothing ingredients like panthenol and gentle hydrating ingredients like glycerin to keep skin calm and smooth.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use it around the eyes or on my body?

This moisturizing treatment is generally safe to use on the body and around the eyes, though sensitive skin requires extra gentle care in those thinner areas. It helps soothe and hydrate with panthenol and glycerin, but sensitive skin of this type needs products rich in calming plant extracts and barrier-strengthening ingredients without heavy fragrances.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Is this moisturizing treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/sa/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/sensitive-skin) — High fit — SAR 69.70 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/sa/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/sensitive-skin) — High fit — SAR 162.01 at Amazon
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/sa/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/sensitive-skin) — High fit — SAR 155.60 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — SAR 191.00 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/sa/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — SAR 141.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/sa/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — SAR 132.22 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Paeonia Suffruticosa Branch Leaf Extract Flower, 1,2-Hexanediol, Glycerin, Panthenol, Glycereth-26, Alanyl Glutamine, Lactobacillus Soybean Extract Ferment, Sodium Chloride, Sodium Bicarbonate, Peg-60 Hydrogenated Castor Oil, Saccharomyces Barley Seed Ferment Filtrate, Saccharomyces Potato Extract Ferment Filtrate, Water, Dipotassium Glycyrrhizate, Ethylhexylglycerin, Xanthan Gum, Glucose, Hydrolyzed Hyaluronic Acid, Potassium Chloride, Glycine Soja Soybean Peptide, Sodium Phosphate, Lysine Hcl, Sodium Pyruvate, Isoleucine, Leucine, Tyrosine, Threonine, Valine, Arginine Hcl, Phenylalanine, Cystine, Calcium Chloride, Histidine Hcl, Serine, Glycine, Methionine, Tryptophan, Inositol, Folic Acid, Niacinamide, Pyridoxine Hcl, Thiamine Hcl, Riboflavin, Oligopeptide-1, Oligopeptide-2, Oligopeptide-3, Oligopeptide-4, Oligopeptide-6
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/the-first-geniture/cell-essential-source/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-first-geniture/cell-essential-source/for/sensitive-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-first-geniture/cell-essential-source/for/sensitive-skin