# Skinbetter Science Alto Advanced Defense and Repair Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Skinbetter Science](https://lovi.care/skincare/sa/brands/skinbetter-science)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin due to the presence of Niacinamide and Tetrahexyldecyl Ascorbate, which offer antioxidant activity and support barrier repair.
- The serum provides excellent antioxidant protection with Chlorogenic Acids and Ergothioneine, shielding your skin from pollution and environmental stressors.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients and the presence of soothing ingredients like Licorice Root Extract and Bisabolol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Tetrahexyldecyl Ascorbate, Hydrolyzed Sodium Hyaluronate, Ergothioneine, Superoxide Dismutase

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes. ([Free Radical Biology & Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26021820/))
- An ergothioneine-sodium hyaluronate dressing scavenges free radicals, reduces oxidative stress, cellular apoptosis, and inflammation in vitro and in vivo to protect against radiation-induced skin injury. ([ACS Applied Materials & Interfaces, 2024](https://pubmed.ncbi.nlm.nih.gov/38813785/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Ergothioneine at submicromolar concentrations ameliorated UVA-induced skin aging in human dermal fibroblasts by inhibiting the AP-1 pathway and activating Nrf2-mediated antioxidant genes. ([Oxidative Medicine and Cellular Longevity, 2020](https://pubmed.ncbi.nlm.nih.gov/32104530/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))

## What reviewers say

This serum is highly praised for its sophisticated formula that significantly enhances skin radiance, tone, and texture. Its elegant, non-tacky texture is frequently mentioned as a positive attribute, making it easy to incorporate into daily routines. The primary drawback noted by users is the high price point, with some experiencing low-frequency issues like dryness or a slight yellow residue.

- Liked: Elegant texture (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Improves radiance (often mentioned)
- Liked: Reduces redness (often mentioned)
- Liked: Non-irritating formula (sometimes noted)
- Disliked: Potential dryness (rarely noted)
- Disliked: Rare reactions (rarely noted)
- Disliked: Yellow residue (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes skinbetter science Alto Advanced Defense and Repair Serum a great fit for mature skin?

This serum is a great fit for mature skin because it contains niacinamide and tetrahexyldecyl ascorbate, which offer antioxidant activity and support barrier repair. It also provides excellent antioxidant protection with chlorogenic acids and ergothioneine to help shield your skin from pollution and environmental stressors.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for mature skin?

Niacinamide, Tetrahexyldecyl Ascorbate, Hydrolyzed Sodium Hyaluronate, Ergothioneine, and Superoxide Dismutase make this serum a great fit for mature skin. These key ingredients offer antioxidant activity, support barrier repair, and help protect your skin from environmental stressors.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Vitamin C do for mature skin?

Vitamin C helps smooth out wrinkles, fade dark spots, and calm redness on mature skin. It also boosts collagen production to make skin firmer and protects against everyday environmental stress.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29104718/), [Dermatologic Surgery, 2002](https://pubmed.ncbi.nlm.nih.gov/11896774/)

### Where does it go in a skincare routine for mature skin?

This treatment is a great fit for your mature skin and is used in the evening routine. Applying it at night helps avoid any potential issues with sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and following with your retinol, or by using this in the morning and your retinol at night. This helps keep mature skin smooth and protected without causing irritation.

### How often should I use it?

This treatment is a great fit for mature skin and is used in the evening routine. Antioxidants and topicals like this help support skin rejuvenation and protect against everyday environmental stress with a very low risk of irritation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can it clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. It features a very safe formula with soothing ingredients and a low risk of dryness or irritation.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — SAR 865.37 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/sa/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — SAR 5,271.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Niacinamide, Lauryl Lactate, Dimethyl Isosorbide, Pyrroloquinoline Quinone Allyl Ester, Hydrolyzed Sodium Hyaluronate, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Benzylidene Dimethoxydimethylindanone, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Theobroma Cacao Seed Extract, Curcuma Longa Root Extract, Olea Europaea Fruit Extract Olive Fruit Extract, Euterpe Oleracea Fruit Extract, Trifluoroacetyl Tripeptide-2, Buddleja Officinalis Flower Extract, Coffea Arabica Extract Cell Leaf Coffee Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Superoxide Dismutase, Ubiquinone, Plankton Extract, Micrococcus Lysate, Arginine, Zingiber Officinale Root Extract, Ceramide Np, Ceramide Ap, Ceramide Eop, Linoleic Acid, Linolenic Acid, Sea Whip Extract, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium Pca, Pentylene Glycol, Methyl Gluceth-20, Glycerin, Helianthus Annuus Wax Seed Sunflower Wax Seed, Acacia Decurrens Wax Flower, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Carbomer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dextran, Ricinoleth-40, Sodium Hydroxide, Citric Acid, Sodium Phytate, Ethylhexylglycerin, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/mature-skin