# SKIN1004 Probio-Cica Intensive Ampoule for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [SKIN1004](https://lovi.care/skincare/sa/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin and sensitive skin, this product effectively addresses redness and irritation with Centella Asiatica Extract and Niacinamide, which calm inflammation and strengthen your skin barrier.
- The formula's inclusion of Kidney Vetch further supports its soothing properties, making it a beneficial choice for managing sensitivity.
- This product is safe for your sensitive skin as it contains no harsh or prohibited ingredients, minimizing the risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Niacinamide, Glycerin, Butylene Glycol, Propanediol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))

## What reviewers say

This ampoule is widely celebrated as a holy grail for repairing damaged skin barriers and soothing irritation, particularly for those with dry, sensitive, or acne-prone skin. Users consistently report a glass skin effect, noting that the milky, viscous texture provides deep hydration and calms redness without leaving a heavy residue. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Barrier repair (often mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Gentle/non-irritating (often mentioned)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Texture heaviness (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Skin1004 Probio-Cica Intensive Ampoule a great fit for sensitive skin?

This product is a great fit because it helps calm redness and irritation while strengthening your skin barrier using Centella Asiatica Extract and Niacinamide. Its soothing properties are further supported by Kidney Vetch, and it is made without harsh ingredients to keep your skin safe and minimize irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this ampoule a good fit for sensitive skin?

Centella Asiatica Extract and Niacinamide make this ampoule a great fit because they calm redness and strengthen your skin barrier. Kidney Vetch further supports these soothing properties, making it gentle and safe for easily irritated skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Centella Asiatica Extract do for sensitive skin?

Centella asiatica extract helps calm sensitive skin and keeps it comfortable by easing irritation and supporting moisture retention. Using this ingredient helps soothe redness and supports a healthy skin barrier with a very low likelihood of irritation.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this ampoule go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this ampoule with retinol, and in what order?

Yes, you can use this ampoule with retinol by applying the ampoule after your retinol treatment to help calm and soothe any potential irritation. Because the formula contains centella asiatica extract and niacinamide, it is unlikely to cause discomfort on sensitive skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use this ampoule?

This treatment is great for your sensitive skin and is designed to be used in your evening routine. Using it at night keeps things simple and safe, and it is unlikely to cause irritation.

### Can this ampoule clog pores, cause breakouts or purging for sensitive skin?

Skin1004 Probio-Cica Intensive Ampoule is unlikely to cause breakouts, as reviewers rarely report clogged pores and the formula avoids harsh ingredients that trigger sensitive skin. It helps calm irritation while keeping your skin soft and smooth.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — SAR 865.37 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sa/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — SAR 130.97 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — SAR 191.00 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/sa/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — SAR 141.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/sa/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — SAR 132.22 at Amazon

## Where to buy

- Amazon.sa: SAR 45.15 (https://www.amazon.sa/dp/B0BTRWGQNV?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Propanediol, Caprylic Capric Triglyceride, Niacinamide, 1,2-Hexanediol, Dipropylene Glycol, Polyglyceryl-4 Isostearate, Kidney Vetch
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin