# ROUND LAB Pine Calming Cica Ampoule for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [ROUND LAB](https://lovi.care/skincare/sa/brands/round-lab)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this formula leverages capryloyl salicylic acid for mild exfoliation and pore refinement, addressing oily shine effectively.
- The inclusion of sodium hyaluronate provides essential humectant action, while asiaticoside, madecassoside, and madecasic acid work synergistically to calm and strengthen your skin barrier.
- This product is safe for your skin, as it contains no harsh ingredients and includes soothing components that minimize irritation risk.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Pine Extract, Centella Asiatica Extract, Sodium Hyaluronate, Glycerin, Madecassoside

## What the research says

- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- A xanthan gum and alginate-based bioadhesive film loaded with pycnogenol provides sustained drug release within 24 hours, achieves a safe maximum concentration of ~ 0.2 mg/mL for keratinocytes, and absorbs simulated wound fluid, demonstrating suitability for topical wound treatment. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33802607/))
- Topical treatment with Pinus brutia bark extract cream significantly accelerated incision wound healing in albino rats, demonstrating a 35% decrease in MDA and a 46.8% increase in SOD activity compared to the control group. ([Die Pharmazie, 2013](https://pubmed.ncbi.nlm.nih.gov/23444785/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream. ([International Journal of Cosmetic Science, 2008](https://pubmed.ncbi.nlm.nih.gov/18452433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly recommended for those with sensitive, oily, and acne-prone skin due to its fast-absorbing, watery texture that effectively calms redness and inflammation without causing breakouts. Users appreciate its gentle formulation and ability to refine skin texture. However, individuals with dry skin may find it insufficient on its own and need to layer with a richer moisturizer.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Non-irritating formula (often mentioned)
- Liked: Gentle texture improvement (sometimes noted)
- Disliked: Insufficient for dry skin (sometimes noted)
- Disliked: Small volume/price (sometimes noted)
- Disliked: Breakouts/reactions (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ROUND LAB Pine Calming Cica Ampoule a great fit for combination skin?

This treatment is a great fit for combination skin because it uses capryloyl salicylic acid for mild exfoliation to help control oily shine. It also includes sodium hyaluronate to boost hydration and centella asiatica ingredients to calm the skin and strengthen your skin barrier.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for combination skin because it uses capryloyl salicylic acid to gently clear pores and control oily shine. It also includes sodium hyaluronate and soothing plant extracts like madecassoside to keep dry areas hydrated and calm your skin barrier.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Pine Extract do for combination skin?

Pine extract helps calm combination skin by reducing redness and protecting against daily environmental stress. It is unlikely to cause irritation and may help keep your skin looking balanced and clear.
Sources: [Redox Report, 2025](https://pubmed.ncbi.nlm.nih.gov/40605175/), [Journal of Food Biochemistry, 2019](https://pubmed.ncbi.nlm.nih.gov/31659812/)

### What does Centella Asiatica Extract do for combination skin?

Centella Asiatica Extract helps balance combination skin by boosting moisture levels while keeping redness and irritation calm. It also supports skin barrier repair to help maintain smooth and healthy skin overall.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in your evening routine after cleansing and before moisturizing, following Lovi's simple approach for safety and extra sun protection. It is unlikely to cause irritation while helping to calm your skin and manage oily shine.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment first to calm and hydrate your skin before following with your retinol product. This helps minimize irritation while keeping your skin balanced and comfortable.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in your evening routine, applying it once a week at first and slowly increasing the frequency if your skin feels comfortable. This gentle approach helps manage oily shine and calms your skin barrier safely.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This ampoule is unlikely to cause breakouts or clogged pores on combination skin, as it has a very low rate of reactions from reviewers. It helps control oily shine with mild exfoliation while calming and strengthening your skin.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — SAR 226.83 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/sa/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — SAR 2,799.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — SAR 865.37 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/sa/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — SAR 166.90 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/sa/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — SAR 39.70 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Butylene Glycol, Dipropylene Glycol, Glycereth-26, Glycerin, 2-Hexanediol, Propanediol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Ethylhexyl Glycerin, Water, Glycoprotein, Indo Mulberry Leaf Extract, Yellow Lotus Root Extract, Indo Mulberry Flower Extract, Hydroxyacetophenone, Asiaticoside, Asiatic Acid, Madecassoside, Madecasic Acid, Sodium Citrate, Capryloyl Salicylic Acid, Disodium Edta, Xanthan Gum, Carbomer, Tromethamine, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/combination-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/round-lab/pine-calming-cica-ampoule/for/combination-skin