# Peter Thomas Roth PEPTIDE SKINJECTION for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/sa/brands/peter-thomas-roth)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Offers moderate benefits for your wrinkles and fine lines, as hyaluronic acid and glycerin provide essential hydration and plumping effects for normal skin. Squalane further supports skin suppleness with its emollient properties.
- Niacinamide and adenosine contribute to overall skin health and radiance, complementing the primary hydrating ingredients.
- The product is safe for your normal skin, with no reported risks of irritation due to the absence of harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/oily-acne-prone-skin): Average

## Key ingredients

Glycerin, Tetrapeptide-1, Hyaluronic Acid

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

This product line is highly praised for its effectiveness in softening fine lines and improving skin texture, with many users reporting smoother and more hydrated skin. Some users have noted a gritty texture in the serum and varying results for deep wrinkle reduction.

- Liked: Reduces fine lines (mostly mentioned)
- Liked: Smooths skin texture (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Liked: Reduces eye puffiness (sometimes noted)
- Disliked: Gritty serum texture (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Drying sensation (rarely noted)
- Disliked: Slow/No results (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Peter Thomas Roth Peptide Skinjection a great fit for mature skin?

Peter Thomas Roth Peptide Skinjection is a great fit for mature skin because hyaluronic acid and glycerin give essential moisture and plumping effects, while squalane helps keep the skin soft. Niacinamide and adenosine also support overall skin health and radiance.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this moisturizing treatment a good fit for mature skin?

Glycerin, hyaluronic acid, and squalane make this moisturizing treatment a great fit by providing essential hydration, plumping up fine lines, and keeping your skin soft. Niacinamide and adenosine also help boost overall skin health and radiance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Tetrapeptide-1 do for mature skin?

Tetrapeptide-1 helps smooth out fine lines and wrinkles while supporting firm, elastic skin as you age. It encourages collagen production and helps protect against everyday skin stress.
Sources: [Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/39204332/), [Skin Pharmacology and Physiology, 2021](https://pubmed.ncbi.nlm.nih.gov/33849044/)

### Where does this moisturizing treatment go in a skincare routine for mature skin?

This moisturizing treatment goes in the evening routine after cleansing and before moisturizing, as treatments with actives fit best at night for simplicity and extra safety around sun exposure. It is safe for mature skin with no reported risks of irritation.

### Can I use this moisturizing treatment with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the treatment after your retinol to help calm the skin and keep it soft and smooth. Using a hydrating moisturizer alongside retinol helps reduce dryness and supports the skin barrier during treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this moisturizing treatment?

You can use this moisturizing treatment in the evening as part of your routine. Daily application helps improve skin hydration, fine lines, and overall texture.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this moisturizing treatment clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula with no reported risks of irritation or harsh substances. It features ingredients like squalane and glycerin that keep skin smooth and hydrated without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Can I use this moisturizing treatment around the eyes or on my body?

This moisturizing treatment is well-suited for the thin skin around the eyes and body because its gentle formula provides essential hydration and plumping effects without irritation. Regular application helps smooth fine lines while keeping delicate skin soft and comfortable.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this moisturizing treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/sa/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/mature-skin) — High fit — SAR 80.75 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/sa/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — SAR 70.40 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/sa/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — SAR 162.01 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sa/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — SAR 429.81 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Chondrus Crispus Powder, Butylene Glycol, Tetrapeptide-1, Hyaluronic Acid, Allantoin, Trehalose, Caffeine, Squalane, Niacinamide, Adenosine, Tocopheryl Acetate, Calcium Lactate, Opuntia Ficus-Indica Flower Extract, Chondrus Crispus Extract, Chlorphenesin, Ricinus Communis Seed Oil Castor Seed Oil, Potassium Chloride, Dextrin, Sodium Phytate, Caprylyl Glycol, Citric Acid, Ceratonia Siliqua Gum, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Ultramarines, Chromium Hydroxide Green Ci 77289, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
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- Canada: https://lovi.care/skincare/ca/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/peter-thomas-roth/peptide-skinjection/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-skinjection/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-skinjection/for/mature-skin