# Medimine Phyto Enzyme Powder Wash for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: Medimine
Category: [Exfoliants](https://lovi.care/skincare/sa/best/exfoliators)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best products for mature skin.

## Why this fit

- Excellent suitability for your normal skin as papain and niacinamide work synergistically to provide enzymatic exfoliation and stimulate collagen, effectively addressing your concerns with wrinkles and fine lines.
- The formula also offers excellent cleansing and pore decongestion due to high concentrations of papain and sodium cocoyl isethionate, further enhancing your skin's overall health.
- The safety profile is excellent, with soothing ingredients like Chamomilla Recutita Flower Extract and Glycyrrhiza Glabra Root Extract ensuring no irritation for your normal skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/oily-acne-prone-skin): Superior

## Key ingredients

Papain, Pearl Extract, Niacinamide, Licorice Root Extract, Chamomile Flower Extract

## What the research says

- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream. ([International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Micro and nanosized pearl powders increased skin cell proliferation and migration, accelerated wound closure, enhanced biomechanical strength, improved collagen deposition, and promoted angiogenesis in rats, with nanoscale pearl powder showing the highest efficiency. ([Drug Development and Industrial Pharmacy, 2019](https://pubmed.ncbi.nlm.nih.gov/30950303/))
- Topical pearl extract gel inhibited UV-irritated skin wrinkles, laxity, thickness, and dryness, upregulated antioxidant enzyme activities, decreased MDA levels, and suppressed inflammatory factors in UV-irradiated mice compared to untreated controls, with high-dose PEG showing superior effects to Vitamin E. ([Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/))
- Seawater pearl powder treatment significantly improves UV-induced photoaging and restores skin tissue structure in mice by reducing MMP-1, enhancing collagen I, inhibiting the MAPK signaling pathway, and scavenging reactive oxygen species. ([Evidence-based Complementary and Alternative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34925534/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical chamomile oil combined with a night splint significantly improved the symptomatic and functional status of patients with severe carpal tunnel syndrome compared to placebo, while electrodiagnostic parameters showed no significant changes. ([Complementary Therapies in Clinical Practice, 2015](https://pubmed.ncbi.nlm.nih.gov/26573447/))
- German chamomile solution applied twice a day healed peristomal skin lesions significantly faster than once-a-day 1% hydrocortisone ointment in colostomy patients, with a mean healing time of 8.89 days versus 14.53 days. ([Ostomy/wound Management, 2011](https://pubmed.ncbi.nlm.nih.gov/21617262/))
- Topical chamomile reduces the incidence and delays the occurrence of phlebitis due to amiodarone infusion in coronary care patients compared to a placebo of lanoline. ([Journal of Integrative Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28844214/))

## What reviewers say

Based on limited data, users generally praise this powder wash for its ability to dramatically improve skin texture and brightness without causing tightness, often describing it as a "holy grail" for smoothing rough skin. However, experiences are polarized regarding sensitivity; while many find it gentle, a minority report significant irritation and redness, and some struggle with the powder packaging.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightening effect (often mentioned)
- Liked: Non-stripping (often mentioned)
- Liked: Clears bumps/acne (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Makeup removal (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Could be used as part of your PM routine once a week, increasing to 2-3 times if your skin tolerates it well.
- Place this enzyme powder cleanser in your weekly routine after your regular cleanser and before your hydrating toner.
- Mix a small amount of the enzyme powder cleanser with water in your hands to create a soft foam before applying.
- Gently massage the foam onto your damp face using circular motions, then rinse thoroughly with warm water.
- Avoid the sensitive eye area and always apply SPF the morning after using exfoliating products.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes Medimine Phyto Enzyme Powder Wash one of the best fits for mature skin?

Medimine Phyto Enzyme Powder Wash is an exceptional fit for mature skin because papain and niacinamide work together to gently clear away dead skin cells and help smooth out fine lines and wrinkles. Soothing ingredients like chamomile flower extract and licorice root extract keep the formula gentle and help prevent irritation.
Sources: [International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this cleanser a good fit for mature skin?

Papain and niacinamide make this cleanser a great fit because they gently sweep away dead skin cells and help smooth out fine lines. Niacinamide also helps slow down signs of aging while keeping the skin well tolerated.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### What does Papain do for mature skin?

Papain gently exfoliates the outer layer of skin by breaking down surface proteins, which helps reveal smoother and fresher skin. This gentle shedding process may improve skin texture and reduce the look of dullness in mature skin.
Sources: [International Journal of Cosmetic Science, 2022](https://pubmed.ncbi.nlm.nih.gov/35892222/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34897928/)

### What does Pearl Extract do for mature skin?

Pearl extract helps smooth mature skin by reducing dryness and wrinkles while supporting antioxidant activity. It is unlikely to irritate and may help protect against UV-related aging effects.
Sources: [Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/), [Marine Biotechnology, 2023](https://pubmed.ncbi.nlm.nih.gov/36629944/)

### Where does this cleanser go in a skincare routine for mature skin?

This enzyme powder cleanser is used once a week in the routine for mature skin, or more often if your skin tolerates it well and shows good results. It gently smooths and refreshes your skin with papain while keeping it calm with soothing chamomile and licorice root.

### Can I use this cleanser with retinol, and in what order?

You can use this enzyme powder cleanser alongside retinol by adding it to your weekly routine rather than the same day you apply retinol, helping you avoid irritation. Using soothing ingredients like chamomile and licorice root helps keep mature skin calm while papaya enzymes and niacinamide smooth fine lines.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### How often should I use this cleanser?

You can start using this enzyme powder cleanser once a week as part of your routine. If your skin handles it well and you see good results, you may carefully use it more often.

### Can this cleanser clog pores, cause breakouts or purging for mature skin?

This cleanser is unlikely to clog pores or cause breakouts for mature skin, as it provides deep cleansing and pore decongestion with papain and gentle cleansing agents. Soothing ingredients like chamomile and licorice root help ensure a very low chance of irritation.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### Is this cleanser fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Dr. Barbara Sturm Enzyme Cleanser](https://lovi.care/skincare/sa/p/dr-barbara-sturm/enzyme-cleanser/for/mature-skin) — High fit — SAR 658.00 at Amazon
- [Tatcha The Rice Polish: Deep](https://lovi.care/skincare/sa/p/tatcha/the-rice-polish-deep/for/mature-skin) — High fit — SAR 319.44 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/sa/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/mature-skin) — High fit — SAR 117.35 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Zea Mays Starch, Sodium Cocoyl Isethionate, Sodium Lauroyl Glutamate, Sorbitol, Papain, Pearl Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Allantoin, Citric Acid, Disodium Edta, Isopropyl Palmitate, Niacinamide, Betaine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/medimine/phyto-enzyme-powder-wash/for/mature-skin