# Medicube Triple Collagen Serum 4.0 for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Medicube](https://lovi.care/skincare/sa/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate hydration and plumping benefits for your oily skin due to the inclusion of multiple collagen forms and sodium hyaluronate, complemented by niacinamide for oil regulation.
- While it provides general hydration and firming, it lacks specific ingredients to target your primary concerns of acne, blemishes, and breakouts.
- The product is safe for your oily skin, with no identified risks of irritation from harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Collagen Extract, Sodium Hyaluronate, Niacinamide, Adenosine, Glycerin

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users consistently praise this serum for delivering a "glass skin" finish and deep hydration, making it a favorite for those with dry, dull, or mature skin. While the plumping and glow-boosting effects are widely celebrated, some users with oily or sensitive skin find the formula slightly sticky or the fragrance too strong.

- Liked: Glass skin glow (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Silky texture (sometimes noted)
- Disliked: Added fragrance (sometimes noted)
- Disliked: Sticky or heavy (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Price vs. quantity (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Triple Collagen Serum 4.0 work for oily acne-prone skin?

This serum offers moderate hydration and plumping for your oily skin, but it lacks specific ingredients to target acne, blemishes, and breakouts. An ideal treatment for this skin needs effective ingredients like niacinamide and propolis or vitamin C that clear blemishes and control excess oil while remaining comfortable and safe for daily use.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Collagen extract and sodium hyaluronate help provide moderate hydration and plumping for your oily skin, while niacinamide assists with oil regulation. However, because it lacks targeted ingredients for acne and breakouts, an oily acne-prone skin type needs a treatment with ingredients like propolis, Vitamin C, and soothing extracts to address blemishes and excess oil.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### What does Collagen Extract do for oily acne-prone skin?

Collagen Extract is unlikely to clog pores and may help calm oily, acne-prone skin by supporting skin repair and reducing inflammation. This type of product works best when it also includes ingredients like niacinamide or gentle exfoliating acids to help balance oil and keep pores clear.
Sources: [Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. Oily acne-prone skin needs a treatment that brings acne-fighting ingredients like salicylic acid or benzoyl peroxide alongside oil control to truly clear breakouts.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your oily skin moderate moisture, followed by your retinol. This product is safe for your skin with no identified risks of irritation from harsh ingredients.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. A product of this type needs acne-fighting ingredients like salicylic acid or benzoyl peroxide to properly care for oily acne-prone skin.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause purging on oily acne-prone skin, as it has a safe makeup with no harsh ingredients. However, because it lacks specific breakout-fighting ingredients, this skin type needs a product that includes acne-targeting actives and oil control.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (linalool, limonene, geraniol, citronellol, citral, and benzyl alcohol) and drying alcohol (alcohol denat).

## Alternatives for oily acne-prone skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/sa/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-acne-prone-skin) — Superior fit — SAR 653.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — SAR 226.83 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sa/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — SAR 130.97 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/sa/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — SAR 166.90 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/sa/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — SAR 39.70 at Amazon

## Where to buy

- Amazon.sa: SAR 50.00 (https://www.amazon.sa/dp/B0DF76CZJX?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 2-Hexanediol, Cyclopentasiloxane, Cyclohexasiloxane, Trehalose, Dimethicone, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Benzyl Benzoate, Linalool, Limonene, Geraniol, Atelocollagen, Desamido Collagen, Citronellol, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Hydroxycitronellal, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Hydroxypropyltrimonium Hyaluronate, Citral, Benzyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin