# MARY & MAY 6 Peptide Complex Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [MARY & MAY](https://lovi.care/skincare/sa/brands/mary-and-may)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your normal skin is provided by multiple peptides like copper tripeptide-1 and hexapeptide-11, which support collagen stimulation and extracellular matrix synthesis.
- The serum offers moderate benefits for wrinkles and fine lines due to the presence of peptides like copper tripeptide-1 and palmitoyl pentapeptide-4 in concentrations that support collagen production.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1

## What the research says

- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- A functionalized dendrimer nanocarrier delivers active ingredients into the dermis and enhances collagen production in human dermal fibroblasts by co-delivering all-trans retinol and palmitoyl pentapeptide-4. ([Acta Biomaterialia, 2025](https://pubmed.ncbi.nlm.nih.gov/39694719/))
- Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks. ([Cureus, 2026](https://pubmed.ncbi.nlm.nih.gov/42500768/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases. ([Inflammation Research, 2010](https://pubmed.ncbi.nlm.nih.gov/20703511/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- Topical treatment with cyclized hexapeptide-9 significantly reduced wrinkles and roughness in crow's feet and forehead compared to vehicle, and generally outperformed retinol in healthy volunteers with aging skin. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/))
- A chemically synthesized homotrimeric collagen peptide exhibited high purity, a stable triple-helical conformation, and excellent thermal stability, while safely enhancing collagen and elastin synthesis in fibroblasts in vitro and increasing skin collagen content, improving skin structure, and enhancing microvessel density in BALB/c mice in vivo. ([Frontiers in Bioengineering and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40357327/))
- The addition of soybean peptide and collagen peptide to normal human dermal fibroblasts increased collagen synthesis and gene expression related to collagen formation, with the highest collagen levels observed when both peptides were added together compared to individual additions. ([International Journal of Food Sciences and Nutrition, 2012](https://pubmed.ncbi.nlm.nih.gov/22264122/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on a very large amount of data, users with diverse skin types consistently praise this serum for its lightweight hydration and ability to plump the skin without irritation. While it is not a miracle cure for deep wrinkles, the majority of users report smoother skin texture, improved elasticity, and a reduction in fine lines after consistent use.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Gentle & non-irritating (often mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Good value (sometimes noted)
- Disliked: Subtle or slow results (sometimes noted)
- Disliked: Consumed quickly (rarely noted)
- Disliked: Rare skin reactions (rarely noted)
- Disliked: Texture too watery (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Mary & May 6 Peptide Complex Serum a great fit for mature skin?

Mary & May 6 Peptide Complex Serum is a great fit because it contains multiple peptides like copper tripeptide-1 and hexapeptide-11, which help support collagen and improve skin elasticity. It also has a very safe formula with no harsh ingredients, meaning it is unlikely to cause irritation on normal skin.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains multiple peptides like copper tripeptide-1, hexapeptide-11, and palmitoyl pentapeptide-4. These ingredients support collagen production and help keep skin firm while smoothing out the look of fine lines and wrinkles. It is also very safe and unlikely to cause any irritation.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### What does Copper Tripeptide-1 do for mature skin?

Copper Tripeptide-1 helps improve mature skin by smoothing out fine lines and wrinkles while boosting firmness and elasticity. It also helps calm irritation, protects against daily damage, and supports a stronger skin barrier.
Sources: [Journal of Biomaterials Science. Polymer Edition, 2008](https://pubmed.ncbi.nlm.nih.gov/18644225/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### What does Hexapeptide-11 do for mature skin?

Hexapeptide-11 helps improve skin firmness and elasticity in mature skin by supporting collagen production and defending cells against oxidative stress. This ingredient protects against premature aging and helps keep the skin looking smooth and youthful.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/), [Skin Pharmacology and Physiology, 2021](https://pubmed.ncbi.nlm.nih.gov/33849044/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure, while helping smooth wrinkles and fine lines.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first and following it with this peptide serum, or by using them on alternating nights to keep your skin calm and smooth. This approach helps you gain the wrinkle-smoothing benefits of both ingredients while maintaining a very safe routine.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### How often should I use it?

Use this serum in your evening routine, applying it after your cleansing toner and before your moisturizer. It is a great fit for mature skin, helping to smooth fine lines safely and without irritation.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because it has an excellent safety profile without harsh ingredients. It is also not an active exfoliant, so it will not cause purging.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — SAR 865.37 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/sa/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — SAR 5,271.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

- Amazon.sa: SAR 54.79 (https://www.amazon.sa/dp/B095YHYF33?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycereth-26, 1,2-Hexanediol, Butylene Glycol, Glycerin, Arginine, Carbomer, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Adenosine, Caprylyl Glycol, Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/mary-and-may/6-peptide-complex-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/mary-and-may/6-peptide-complex-serum/for/mature-skin