# ma:nyo Panthetoin Cream for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [ma:nyo](https://lovi.care/skincare/sa/brands/ma-nyo)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing for your combination skin, as panthenol and ectoin enhance barrier resilience and hydration, which is supportive for oily shine.
- Glycerin and macadamia ternifolia seed oil provide additional humectant action and nourishment, though stronger oil-controlling ingredients would further benefit your oily areas.
- The formulation is safe for your combination skin, featuring soothing ingredients like panthenol and ectoin with no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/oily-acne-prone-skin): High

## Key ingredients

Panthenol, Mangifera Indica Seed Butter, Squalane, Ceramide Np, Hydrolyzed Hyaluronic Acid

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, this cream is highly recommended for dry, dehydrated, and sensitive skin, especially during winter. It provides deep, lasting hydration and strengthens the skin barrier without feeling greasy. While it effectively soothes irritation and improves skin texture, some users with oily skin or those in humid climates find it too rich, and a few mention a slight ingredient scent or difficulty dispensing the product towards the end.

- Liked: Deep long-lasting hydration (mostly mentioned)
- Liked: Elegant non-sticky texture (often mentioned)
- Liked: Hygienic tube packaging (sometimes noted)
- Liked: Soothing & barrier support (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Too heavy for oily skin/summer (sometimes noted)
- Disliked: Dispensing issues (rarely noted)
- Disliked: Slight ingredient scent (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes ma:nyo Panthetoin Cream a great fit for combination skin?

ma:nyo Panthetoin Cream is a great fit because panthenol and ectoin enhance barrier resilience and hydration, which is supportive for oily shine. Glycerin and macadamia ternifolia seed oil provide additional nourishment and keep the skin soft.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for combination skin?

Panthenol and ectoin make this cream a great fit for your combination skin because they build up your skin barrier and boost moisture without clogging your pores. Ingredients like glycerin and macadamia oil add extra nourishment, while soothing agents help keep your skin calm.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Panthenol do for combination skin?

Panthenol helps balance combination skin by boosting moisture while keeping redness and irritation calm. It is unlikely to cause breakouts and may help repair the skin barrier safely.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29577586/)

### What does Mango Seed Butter do for combination skin?

Mango Seed Butter helps soften dry patches on combination skin while providing rich moisture. It works by repairing the skin barrier and supporting the skin healing process, though very heavy amounts may feel greasy on oily areas.
Sources: [Indian Journal of Pharmaceutical Sciences, 2008](https://pubmed.ncbi.nlm.nih.gov/20046792/), [Phytotherapy Research, 2020](https://pubmed.ncbi.nlm.nih.gov/31657094/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes after your hydrating toner in the morning and after your treatment step at night. Using a moisturizer as part of a consistent daily routine helps keep skin hydrated and supports the skin barrier.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol by applying the retinol first and following it with the moisturizer. Using a barrier-enhancing moisturizer helps reduce skin irritation and dryness while your skin adjusts to retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this cream?

You can use this moisturizer twice a day, morning and evening, as part of your daily routine. Regular application helps keep your skin hydrated and supports the skin barrier while being safe for your skin type.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin, as it features a safe formulation with soothing ingredients and no harsh or prohibited substances. However, some reviewers note it may feel too heavy for oily areas during warmer months.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this cream around the eyes or on my body?

You can safely use this cream around your eyes and on your body because its gentle formula provides reliable moisture and barrier care for thinner skin areas. Studies on panthenol and related moisturizing ingredients show they support hydration and skin comfort without causing irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Behenyl alcohol, cetearyl alcohol, and stearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/sa/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — SAR 78.95 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/sa/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — SAR 146.71 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/sa/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — SAR 25.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/sa/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — SAR 166.90 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/sa/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — SAR 46.95 at Amazon

## Where to buy

- Amazon.sa: SAR 147.56 (https://www.amazon.sa/dp/B0C5R6DM67?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Caprylyl Methicone, Octyldodecanol, Pentylene Glycol, Butylene Glycol Dicaprylate Dicaprate, Mangifera Indica Seed Butter, Panthenol, Pentaerythrityl Tetraethylhexanoate, Polyglyceryl-3 Methylglucose Distearate, Behenyl Alcohol, Methylpropanediol, Polymethylsilsesquioxane, 1,2-Hexanediol, Macadamia Ternifolia Seed Oil, Cetearyl Olivate, Sorbitan Olivate, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Acetyl Glucosamine, Bis-Diglyceryl Polyacyladipate-2, Ectoin, Glyceryl Stearate, Polyglyceryl-3 Distearate, Cetearyl Alcohol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Stearyl Alcohol, Caprylyl Glycol, Cetearyl Glucoside, Squalane, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Xanthan Gum, Sorbitan Isostearate, Allantoin, Glyceryl Stearate Citrate, Trisodium Ethylenediamine Disuccinate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Candida Bombicola Glucose Methyl Rapeseedate Ferment, Butylene Glycol, Tocopherol, Yeast Extract Ferment, Dipropylene Glycol, Hydrolyzed Hyaluronic Acid, Propanediol, Ceramide Np, Phytosphingosine, Hydroxyphenyl Propamidobenzoic Acid, Sodium Chloride, Ascorbyl Palmitate, Sodium Bicarbonate, Calcium Chloride, Potassium Chloride
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/ma-nyo/panthetoin-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/ma-nyo/panthetoin-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/ma-nyo/panthetoin-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/ma-nyo/panthetoin-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/ma-nyo/panthetoin-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/ma-nyo/panthetoin-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/ma-nyo/panthetoin-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/ma-nyo/panthetoin-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/ma-nyo/panthetoin-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/ma-nyo/panthetoin-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/ma-nyo/panthetoin-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/ma-nyo/panthetoin-cream/for/combination-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/ma-nyo/panthetoin-cream/for/combination-skin