# Lancôme Rénergie H.P.N. 300-Peptide Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Lancôme](https://lovi.care/skincare/sa/brands/lancome)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and treatment for your combination skin, as glycerin and hydrolyzed hyaluronic acid provide hydration and plumping effects, though it lacks specialized ingredients to directly target acne and breakouts.
- Tocopherol offers some soothing benefits, which is supportive for your skin concerns, but the formula does not provide optimal oil control for your oily areas.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptides, Sodium Hyaluronate, Niacinamide, Hydrolyzed Lupine Protein, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.

- Liked: Luxurious non-greasy texture (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Visible anti-aging results (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant fragrance (sometimes noted)
- Liked: Refillable packaging (sometimes noted)
- Disliked: Heavy for oily skin (rarely noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Skin irritation (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Lancôme Rénergie H.P.N. 300-Peptide Cream work for acne-prone skin?

Lancome Renergie H.P.N. 300-Peptide Cream works reasonably well for acne-prone skin, as it offers moderate hydration and soothing benefits without any irritation, though other products fit this skin type better. To work best for acne-prone skin, a product of this type needs specialized ingredients to directly target breakouts and provide oil control for oily areas.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for acne-prone skin?

Glycerin, hydrolyzed hyaluronic acid, and tocopherol make this cream a good fit for acne-prone skin by providing hydration and soothing benefits. However, because it lacks specialized ingredients to directly target acne and breakouts and does not provide optimal oil control, a product of this type needs acne-fighting ingredients, oil-controlling agents, and soothing extracts to truly fit this skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Peptides do for acne-prone skin?

Peptides help calm acne-prone skin by reducing redness and soothing inflammation while supporting the skin barrier. Certain advanced peptide formulas also work to target acne-causing bacteria and help balance oil production.
Sources: [Biochemical Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39662606/), [Bioresources and Bioprocessing, 2026](https://pubmed.ncbi.nlm.nih.gov/42219443/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning and as your final step at night. While it provides good hydration, acne-prone skin works best with products that also include targeted breakout-clearing ingredients and oil control.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use it with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it after your retinol to help soothe dryness and keep your skin soft. This product type works well for acne-prone skin when it includes ingredients that clear blemishes and balance oil.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular daily application helps improve skin moisture and barrier function.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to cause irritation on your skin, but it does not provide optimal oil control for your acne-prone areas. A product for this skin needs specialized ingredients to directly target breakouts and help balance oil.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is generally safe to use on the body and around the eyes, as its gentle formula lacks harsh ingredients that typically cause irritation. However, because skin is much thinner around the eyes and varies in thickness across the body, results may differ compared to facial application.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is it fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/sa/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — SAR 78.95 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/sa/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — SAR 146.71 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/sa/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — SAR 14.95 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/sa/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — SAR 53.04 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/sa/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — SAR 75.00 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin