# La Roche-Posay Toleriane Dermallergo Night for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [La Roche-Posay](https://lovi.care/skincare/sa/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin, this formula leverages squalane and glycerin to provide excellent moisturization and support barrier resilience, addressing your concerns about wrinkles and fine lines with adenosine and niacinamide.
- The emollient and humectant actions of squalane and glycerin work synergistically to hydrate and enhance your skin's natural barrier function.
- The product is safe for your skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/oily-acne-prone-skin): High

## Key ingredients

Thermal Spring Water, Squalane, Niacinamide, Butyrospermum Parkii Shea Butter, Dimethicone

## What the research says

- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Avène Thermal Spring Water significantly decreased postpeeling redness and reduced the overall sensitive scale of consumers by 47% compared to mineral-rich thermal spring water in human volunteers. ([Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))

## What reviewers say

Users frequently report waking up to softer, plumper, and less irritated skin. A minority of users with oily or acne-prone skin found the formula too heavy or experienced breakouts.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Not hydrating enough (rarely noted)
- Disliked: Sticky or heavy (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Toleriane Dermallergo Night a great fit for mature skin?

This moisturizer is a great fit for mature skin because it uses squalane and glycerin to deeply hydrate and strengthen your natural skin barrier. It also helps smooth out fine lines and wrinkles using adenosine and niacinamide.
Sources: [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because it uses squalane and glycerin to deeply hydrate and strengthen your skin barrier. It also includes adenosine and niacinamide, which help smooth out wrinkles and fine lines.
Sources: [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Thermal Spring Water do for mature skin?

Thermal Spring Water helps mature skin by boosting hydration, calming irritation, and supporting a more stable skin barrier against daily stress. Regular use of mineral-rich thermal water may also improve overall skin comfort and smoothness as skin ages.
Sources: [International Journal of Biometeorology, 2025](https://pubmed.ncbi.nlm.nih.gov/41081920/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### Where does this cream go in a skincare routine for mature skin?

This cream goes in the moisturizer step, used in both your morning and evening routines after cleansers and toners. A consistent daily routine with a moisturizer helps improve hydration and smoothness in dry or aging skin.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first, letting it absorb, and then following with this moisturizer. This routine helps keep your skin soft and is unlikely to cause irritation because the formula supports your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### How often should I use this cream?

This cream is a great fit for your mature skin and is gentle enough to use every day in both your morning and evening routines. Applying it regularly helps keep your skin hydrated and smooth while working to soften the look of fine lines and wrinkles over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts, as only a small number of reviewers report this issue. The formula is safe for your skin with no harsh ingredients that typically cause irritation or breakouts.

### Can I use this cream around the eyes or on my body?

You can use this moisturizer around the eyes and on the body because it is safe and gentle. While the skin around the eyes and on different parts of the body varies greatly in thickness, this formula is well-tolerated and unlikely to cause irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon
- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/sa/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — SAR 48.00 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/sa/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — SAR 540.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/sa/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — SAR 429.81 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Squalane, Butyrospermum Parkii Shea Butter, Glycerin, Dimethicone, Pentylene Glycol, Niacinamide, Sodium Hydroxide, Tocopherol, Adenosine, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Citric Acid, Disodium Edta, Ethylhexylglycerin, Sodium Citrate, Xanthan Gum, Polysorbate 20
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/toleriane-dermallergo-night/for/mature-skin