# iS Clinical Super Serum Advance+ for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [iS Clinical](https://lovi.care/skincare/sa/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin brightening and smoothing texture for your oily skin due to the presence of ascorbic acid and arbutin, which also provide antioxidant and brightening effects relevant for your acne, blemishes, and breakouts.
- Zinc sulfate further supports oil control and antioxidant activity, complementing the benefits for your oily skin.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Ascorbic Acid, Sodium Hyaluronate, Arbutin, Tripeptide-1, Madecassic Acid

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))

## What reviewers say

This serum is highly regarded for its ability to brighten skin and reduce the appearance of scars and stretch marks. It is often described as a lightweight, fast-absorbing treatment suitable for acne-prone and aging skin, although its high price is a frequent concern among users.

- Liked: Brightens skin tone (mostly mentioned)
- Liked: Anti-aging effects (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces scars/marks (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Non-irritating (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Application sensation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Packaging/Value (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes iS Clinical Super Serum Advance+ a great fit for oily acne-prone skin?

iS Clinical Super Serum Advance+ is a great fit because ascorbic acid and arbutin smooth your skin texture and brighten dark spots while helping fade breakouts. Zinc sulfate supports oil control, and the formula has an excellent safety profile that is unlikely to cause irritation on oily skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Ascorbic acid and arbutin make this serum a great fit by brightening your skin and smoothing its texture, while zinc sulfate helps control oil. These ingredients work together safely without irritating your oily, breakout-prone skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for oily acne-prone skin?

Vitamin C helps brighten skin, smooth out texture, and improve uneven spots for oily acne-prone skin. It may also help fade marks left behind by blemishes.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product, or by using them on alternate nights to keep your skin calm. This helps you get the smoothing and brightening benefits while keeping irritation unlikely.

### How often should I use this serum?

You can use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is very safe for your oily skin and is unlikely to cause any irritation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for oily acne-prone skin because it helps control oil and smooth texture without causing irritation or breakouts. Its formula includes ascorbic acid, arbutin, and zinc sulfate, and it is very safe with no harsh ingredients that typically clog pores.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — SAR 226.83 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/sa/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-acne-prone-skin) — Superior fit — SAR 653.00 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sa/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — SAR 130.97 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/sa/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — SAR 166.90 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/sa/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — SAR 39.70 at Amazon

## Where to buy

- Amazon.sa: SAR 469.00 (https://www.amazon.sa/dp/B0027583BO?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Ascorbic Acid, Sodium Hyaluronate, Pentylene Glycol, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine Hcl, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin