# iS Clinical Active Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [iS Clinical](https://lovi.care/skincare/sa/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation and hydration for your normal skin, with glycerin and willow bark extract providing mild benefits for redness and irritation.
- The inclusion of saccharum officinarum extract and vaccinium myrtillus leaf extract further supports gentle exfoliation and skin clarity.
- The product is safe for your sensitive skin, as it lacks any harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/oily-acne-prone-skin): High

## Key ingredients

Saccharum Officinarum Extract, Vaccinium Myrtillus Extract, Arbutin, Willow Bark Extract, Polyporus Umbellatus Extract Mushroom Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## What reviewers say

Users consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.

- Liked: Clears Acne & Breakouts (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Disliked: High Price Point (often mentioned)
- Liked: Anti-Aging Benefits (sometimes noted)
- Liked: Fast Visible Results (sometimes noted)
- Disliked: Intense Tingling Sensation (sometimes noted)
- Disliked: Drying for Some (rarely noted)
- Disliked: Risk of Counterfeits (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does iS Clinical Active Serum work for sensitive skin?

iS Clinical Active Serum works moderately well for sensitive skin, offering gentle exfoliation and hydration with willow bark extract to help calm redness and irritation. Treatments that fit sensitive skin better need soothing ingredients like niacinamide, snail secretion filtrate, and antioxidants to comfort the skin without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Glycerin and willow bark extract make this serum a fit for sensitive skin by offering mild hydration and helping to calm redness and irritation. Glycerin helps maintain skin moisture, while willow bark extract supports a comfortable feel.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Sugarcane Extract do for sensitive skin?

Sugarcane Extract helps gently clear away dead skin cells so sensitive skin feels smooth, though it may sometimes cause mild stinging. To keep skin calm, a product of this type needs soothing ingredients like aloe or chamomile and a gentle, alcohol-free formula.

### What does Bilberry Fruit Extract do for sensitive skin?

Bilberry fruit extract is a gentle addition that helps calm sensitive skin and boost antioxidant protection. This ingredient is unlikely to cause irritation and may help improve overall skin health and smoothness.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/)

### Where does it go in a skincare routine for sensitive skin?

Apply this treatment in the evening, starting once a week to see how your skin reacts. This product of this type needs gentle exfoliating ingredients and soothing hydrators to keep your skin smooth and calm.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first, waiting for it to absorb, and then following with this serum. This product is unlikely to cause irritation on sensitive skin, though sensitive skin generally benefits more from products that prioritize soothing hydration and gentle barrier support without strong active acids.

### How often should I use it?

You can use this treatment once a week in the evening, and if your sensitive skin tolerates it well without irritation, you may carefully use it more often. This product provides moderate exfoliation and hydration, but sensitive skin needs a product that prioritizes gentle, deeply calming ingredients and barrier-supporting hydrators.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is safe and unlikely to clog pores or cause breakouts for sensitive skin because it lacks harsh ingredients, but it may cause an intense tingling sensation and needs extra soothing ingredients to fit this skin best.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — SAR 865.37 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/sa/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — SAR 130.97 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — SAR 191.00 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/sa/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — SAR 141.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/sa/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — SAR 132.22 at Amazon

## Where to buy

- Amazon.sa: SAR 456.35 (https://www.amazon.sa/dp/B0073RK3S2?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/active-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/active-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/active-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/active-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/active-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/active-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/active-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/sensitive-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/sensitive-skin