# DRMTLGY Needle-less Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [DRMTLGY](https://lovi.care/skincare/sa/brands/drmtlgy)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers excellent plumping and firming for your normal skin due to Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, and Palmitoyl Tripeptide-5, which promote collagen synthesis and skin elasticity to address wrinkles and fine lines.
- Glycerin and Sodium Hyaluronate provide humectant action, enhancing hydration and skin suppleness.
- The formula is safe for your skin, containing soothing ingredients like Glycerin and Panthenol with no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Palmitoyl Tripeptide-1, Ceramide Eop, Glycerin

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

While many report softer fine lines and improved texture, critical reviews often note that the "needle-less" claim is marketing hyperbole, as the product functions more as a high-quality hydrating peptide serum than a true alternative to injectables.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Excellent texture (often mentioned)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Softens fine lines (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Price point (rarely noted)
- Disliked: Scent and packaging (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes DRMTLGY Needle-less Serum a great fit for mature skin?

This serum is a great fit for mature skin because it offers excellent plumping and firming to smooth out wrinkles and fine lines. Ingredients like Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, and Palmitoyl Tripeptide-5 help build collagen and improve skin elasticity, while glycerin and Sodium Hyaluronate keep your skin deeply hydrated and soft.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, and Palmitoyl Tripeptide-5 help firm the skin and smooth out fine lines and wrinkles. Glycerin and Sodium Hyaluronate also boost hydration to make the skin look soft and plump, while Panthenol and Niacinamide help keep it calm and safe.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, placed after your cleansing toner and before your moisturizer. Putting treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol, but it is best to apply retinol first, let it absorb, and then follow with this serum. This combination helps keep your mature skin soft and hydrated while reducing the look of fine lines and wrinkles.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. Some treatments like this one may also be used in the morning or twice a day.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because it has a safe formula with soothing ingredients and no harsh substances. It helps keep skin calm and hydrated without heavy oils that typically trigger blemishes.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — SAR 865.37 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/sa/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — SAR 5,271.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

- Amazon.sa: SAR 254.55 (https://www.amazon.sa/dp/B0CJK22LNX?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Stem Extract Leaf, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide Eop, Glucosamine Hcl, Glycosaminoglycans, Ceramide Np, Palmitoyl Tripeptide-5, Ceramide Ap, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate Prolinate, Panthenol, Phenoxyethanol, Ethylhexylglycerin, Polysorbate 20, Disodium Edta, Butylene Glycol, Carbomer, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drmtlgy/needle-less-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drmtlgy/needle-less-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/drmtlgy/needle-less-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/drmtlgy/needle-less-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/drmtlgy/needle-less-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/drmtlgy/needle-less-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/drmtlgy/needle-less-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/drmtlgy/needle-less-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/drmtlgy/needle-less-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/drmtlgy/needle-less-serum/for/mature-skin