# BY ECOM Heartleaf Ampoule for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: BY ECOM
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- This formulation is highly suitable for your combination skin, as Houttuynia Cordata Extract and Enantia Chlorantha Bark Extract work synergistically to regulate sebum production and reduce inflammation, directly addressing your acne and blemishes.
- Willow Bark Extract provides mild exfoliation to decongest pores, complementing the anti-inflammatory benefits for your acne-prone skin.
- The product is safe for your skin, featuring soothing ingredients like Centella Asiatica Extract and a gentle formulation free from harsh irritants.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Heartleaf Extract, Sodium Hyaluronate, Glycerin, Centella Asiatica Extract, Curcuma Longa Root Extract

## What the research says

- A hyperoside-enriched fraction of Houttuynia cordata Thunb. inhibited UVB-induced oxidative stress, inflammation, and collagen degradation in human dermal fibroblasts by regulating the MAPK signaling pathway. ([Plants, 2021](https://pubmed.ncbi.nlm.nih.gov/34961096/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Users with oily and acne-prone skin frequently report that this ampoule effectively soothes inflammation and provides a cooling sensation. A moderate number of users also find it hydrating and notice some pore refining effects. A significant minority of reviewers mention a sticky finish and a strong alcohol scent, with some experiencing irritation or breakouts. Results for pore shrinking are mixed.

- Liked: Hydrating texture (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Liked: Aesthetic packaging (sometimes noted)
- Liked: Pore refining (sometimes noted)
- Disliked: Alcohol scent (sometimes noted)
- Disliked: Pore claims weak (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BY ECOM Heartleaf Ampoule a great fit for acne-prone skin?

This ampoule is a great fit because heartleaf extract and bark extract help regulate oil and reduce inflammation while clearing pores. Soothing centella asiatica extract further helps calm the skin without causing irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because heartleaf extract and bark extract help regulate oil and soothe redness. Willow bark extract also gently clears clogged pores to help keep your skin calm and smooth.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### What does Heartleaf Extract do for acne-prone skin?

Heartleaf Extract helps calm acne-prone skin by reducing redness, swelling, and breakouts. Studies show it helps lower inflammation and target acne-causing bacteria without irritating the skin.
Sources: [Bioscience, Biotechnology, and Biochemistry, 2016](https://pubmed.ncbi.nlm.nih.gov/27023331/), [The Journal of Dermatological Treatment, 2021](https://pubmed.ncbi.nlm.nih.gov/31424962/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine after your cleansing toner and before your moisturizer. Treatments with active ingredients are placed in the evening for simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to calm your skin and then following with your retinol. This gentle approach helps reduce potential irritation while supporting your acne-prone skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use this serum?

This treatment is a great fit for your acne-prone skin and is used in the evening. It helps calm blemishes and manage oil, with soothing ingredients that are safe for your skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This ampoule is a great fit for acne-prone skin because heartleaf extract and willow bark extract help calm redness, clear pores, and balance oil without clogging them. It is unlikely to cause breakouts, though some reviewers note a slightly sticky finish.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — SAR 226.83 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/sa/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — SAR 653.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — SAR 865.37 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/sa/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — SAR 53.04 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/sa/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — SAR 78.95 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Houttuynia Cordata Extract, Methylpropanediol, Butylene Glycol, Glycerin, 2-Hexanediol, Cyclohexasiloxane, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Lemon Fruit Extract, Monarda Didyma Leaf Extract, Citrus Aurantium Dulcis Fruit Extract, Anthemis Nobilis Flower Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Pteris Multifida Extract, Cynara Scolymus Leaf Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Chestnut Shell Extract, Piper Methysticum Stem Extract Root Leaf, Panax Ginseng Extract Berry, Corallina Officinalis Extract, Willow Bark Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Paeonia Albiflora Root Extract, Cnidium Officinale Root Extract, Pueraria Thunbergiana Root Extract, Portulaca Oleracea Extract, Enantia Chlorantha Bark Extract, Persea Gratissima Fruit Extract Avocado Fruit Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Water-Soluble Collagen, Aloe Barbadensis Leaf Juice, Sh-Polypeptide-19, Ammonium Acryloyldimethyltaurate Vp Copolymer, Xanthan Gum, Water, Carbomer, Fructooligosaccharides, Beta-Glucan, Disodium Edta, Tromethamine, Polyquaternium-51, Hydrolyzed Hyaluronic Acid, Alcohol, Lecithin, Pistacia Lentiscus Gum, Maltodextrin, Sodium Phosphate, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Oleanolic Acid, Ethylhexylglycerin, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin