# Biotulin Supreme Skin Gel for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Biotulin](https://lovi.care/skincare/sa/brands/biotulin)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate hydration for your dry and sensitive skin, as glycerin and sodium hyaluronate provide humectant action to improve elasticity and skin hydration.
- Imperata cylindrica root extract and grape leaf extract offer general skincare benefits, though additional emollient ingredients would enhance overall comfort for dry skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/oily-acne-prone-skin): Average

## Key ingredients

Acmella Oleracea Extract, Imperata Cylindrica Root Extract, Sodium Hyaluronate, Vitis Vinifera Leaf Extract Grape Leaf Extract, Spilanthol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Treatment with methanolic extract of Acmella oleracea leaves exerted potent antioxidant, anti-inflammatory, antimicrobial, and wound healing effects in vitro by reducing inflammatory mediators, scavenging free radicals, inhibiting bacterial growth, and enhancing fibroblast migration without inducing cytotoxicity. ([Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39357584/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination of Vitis vinifera shoot extract and a biotechnological extract demonstrated significant in vitro and in vivo antioxidant effects and improved clinical signs of photoaged skin in female subjects after a 4-week application. ([Journal of Drugs in Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17691204/))
- A water extract from grapevine leaves inhibited proinflammatory-induced interleukin-8 and vascular endothelial growth factor secretion in human keratinocytes compared to untreated challenged cells. ([Antioxidants, 2019](https://pubmed.ncbi.nlm.nih.gov/31100904/))
- Vitis vinifera L. leaf extract induced significant expression and promoter DNA methylation changes of anti-aging genes SIRT1 and HSP47 in UV-stressed human dermal fibroblasts. ([Molecular Biology Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/32666439/))

## Why other serums fit dry sensitive skin better

- Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35274433/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))
- Hydrogels containing vitamin E-loaded nanostructured lipid carriers exhibited better occlusive properties and long-lasting effects, while vitamin E-loaded nanoemulsions performed a faster skin hydration effect and were selected as more attractive for skin application. ([Colloids and Surfaces. B, Biointerfaces, 2019](https://pubmed.ncbi.nlm.nih.gov/30974262/))

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Biotulin Supreme Skin Gel work for dry sensitive skin?

Biotulin Biotulin Supreme Skin Gel works moderately well for your dry sensitive skin, offering safe hydration through ingredients like glycerin and sodium hyaluronate. It is generally gentle and unlikely to cause irritation, though dry skin of this type needs additional softening ingredients to boost overall comfort and moisture retention.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this gel a good fit for dry sensitive skin?

Glycerin and sodium hyaluronate make this gel a fit by drawing in moisture to improve hydration and elasticity for your dry skin. While it is safe and soothing, a product of this type needs additional softening and nourishing ingredients like ceramides and rich moisturizers to fully comfort very dry skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Acmella Oleracea Extract do for dry sensitive skin?

Acmella oleracea extract helps dry, sensitive skin by boosting hydration and smoothing out rough spots without causing irritation. Studies show it is safe to use and may improve skin texture and reduce fine lines within a few weeks.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### What does Imperata Cylindrica Root Extract do for dry sensitive skin?

Imperata cylindrica root extract helps hydrate dry skin by holding moisture in, making flaky patches feel soft and smooth. It is generally gentle, but dry sensitive skin also needs soothing ingredients and barrier-repairing elements like ceramides to stay calm and comfortable.

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after cleansing and toning, followed by a moisturizer. A product of this type needs additional softening ingredients to give dry skin the best comfort and hydration.

### Can I use this gel with retinol, and in what order?

You can use this gel in your evening routine after cleansing and toning, and before your moisturizer. A product of this type needs additional emollient ingredients to enhance overall comfort for dry skin.

### How often should I use it?

Apply this treatment in the evening as part of your routine. This timing provides simplicity and extra safety around sun exposure, and a product of this type needs additional softening ingredients to keep dry skin fully comfortable.

### Can this gel clog pores, cause breakouts or purging for dry sensitive skin?

This gel is unlikely to clog pores, cause breakouts, or lead to purging on dry sensitive skin because its formula avoids heavy, pore-blocking ingredients and harsh irritants. It offers safe tolerability while helping to keep your skin calm and comfortable.
Sources: [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/), [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/)

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — SAR 865.37 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — SAR 461.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — SAR 226.83 at Amazon

## Pairs well with

- Cleanser: [Illiyoon Ceramide Derma Amino Cleansing Foam](https://lovi.care/skincare/sa/p/illiyoon/ceramide-derma-amino-cleansing-foam/for/dry-sensitive-skin) — Superior fit — SAR 149.44 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/sa/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — SAR 141.00 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/sa/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — SAR 89.00 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol, Imperata Cylindrica Root Extract, Acmella Oleracea Extract, Xanthan Gum, Chondrus Crispus, Benzoic Acid, Phenoxyethanol, Vitis Vinifera Leaf Extract Grape Leaf Extract, Sodium Hyaluronate, Sodium Hydroxide, Carbomer, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin